Synthesis of triarmed poly(ethylene oxide)-deoxycholic acid conjugate and its micellar characteristics

Kang Moo Huh, Kuen Yong Lee, Ick Chan Kwon, Yong Hee Kim, Chulhee Kim, Seo Young Jeong

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The triarmed polyethylene oxide-deoxycholic acid (PEO-DC) was synthesized by the introduction of a triol group to the end of the PEO chain and by a subsequent coupling reaction with deoxycholic acid. These polymeric amphiphiles formed were stable and the spherical micelles in aqueous media have a unimodal size distribution. The triarmed PEO-DC conjugate formed micelles of smaller size at a lower critical micelle concentration than those of monosubstituted ones. This was considered to result from an increase in hydrophobicity of the triarmed conjugate.

Original languageEnglish
Pages (from-to)10566-10568
Number of pages3
JournalLangmuir
Volume16
Issue number26
DOIs
Publication statusPublished - 2000 Dec 26

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry

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    Huh, K. M., Lee, K. Y., Kwon, I. C., Kim, Y. H., Kim, C., & Jeong, S. Y. (2000). Synthesis of triarmed poly(ethylene oxide)-deoxycholic acid conjugate and its micellar characteristics. Langmuir, 16(26), 10566-10568. https://doi.org/10.1021/la000978+