Synthesis, topoisomerase I inhibition and antitumor cytotoxicity of 2,2′

6′,2″-, 2,2′:6′,3″- and 2,2′:6′,4″-terpyridine derivatives

Long Xuan Zhao, Tae Sung Kim, Soo Hyun Ahn, Tae Hyung Kim, Eun kyung Kim, Won Jea Cho, Heesung Choi, Chong Soon Lee, Jung Ae Kim, Tae Cheon Jeong, Ching jer Chang, Eung Seok Lee

Research output: Contribution to journal › Article

90 Citations (Scopus)

Abstract

For the development of new anticancer agents, 2,2′:6′,2″-, 2,2′:6′,3″- and 2,2′:6′,4″-terpyridine derivatives were designed and evaluated for their topoisomerase I inhibitory activity and antitumor cytotoxicity. Structure-activity relationship studies indicated that 2,2′:6′,2″-terpyridine derivatives were highly cytotoxic toward several human tumor cell lines, whereas 2,2′:6′,3″- and 2,2′:6′,4″-terpyridine derivatives were potent topoisomerase I inhibitors.

Original languageEnglish
Pages (from-to)2659-2662
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume11
Issue number19
DOIs
Publication statusPublished - 2001 Oct 8
Externally publishedYes

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Topoisomerase I Inhibitors
Type I DNA Topoisomerase
Structure-Activity Relationship
Cytotoxicity
Tumor Cell Line
Antineoplastic Agents
Derivatives
Tumors
Cells

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Synthesis, topoisomerase I inhibition and antitumor cytotoxicity of 2,2′ : 6′,2″-, 2,2′:6′,3″- and 2,2′:6′,4″-terpyridine derivatives. / Zhao, Long Xuan; Kim, Tae Sung; Ahn, Soo Hyun; Kim, Tae Hyung; Kim, Eun kyung; Cho, Won Jea; Choi, Heesung; Lee, Chong Soon; Kim, Jung Ae; Jeong, Tae Cheon; Chang, Ching jer; Lee, Eung Seok.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 11, No. 19, 08.10.2001, p. 2659-2662.

Research output: Contribution to journal › Article

Zhao, LX, Kim, TS, Ahn, SH, Kim, TH, Kim, EK, Cho, WJ, Choi, H, Lee, CS, Kim, JA, Jeong, TC, Chang, CJ & Lee, ES 2001, 'Synthesis, topoisomerase I inhibition and antitumor cytotoxicity of 2,2′: 6′,2″-, 2,2′:6′,3″- and 2,2′:6′,4″-terpyridine derivatives', Bioorganic and Medicinal Chemistry Letters, vol. 11, no. 19, pp. 2659-2662. https://doi.org/10.1016/S0960-894X(01)00531-5
Zhao LX, Kim TS, Ahn SH, Kim TH, Kim EK, Cho WJ et al. Synthesis, topoisomerase I inhibition and antitumor cytotoxicity of 2,2′: 6′,2″-, 2,2′:6′,3″- and 2,2′:6′,4″-terpyridine derivatives. Bioorganic and Medicinal Chemistry Letters. 2001 Oct 8;11(19):2659-2662. https://doi.org/10.1016/S0960-894X(01)00531-5
Zhao, Long Xuan ; Kim, Tae Sung ; Ahn, Soo Hyun ; Kim, Tae Hyung ; Kim, Eun kyung ; Cho, Won Jea ; Choi, Heesung ; Lee, Chong Soon ; Kim, Jung Ae ; Jeong, Tae Cheon ; Chang, Ching jer ; Lee, Eung Seok. / Synthesis, topoisomerase I inhibition and antitumor cytotoxicity of 2,2′ : 6′,2″-, 2,2′:6′,3″- and 2,2′:6′,4″-terpyridine derivatives. In: Bioorganic and Medicinal Chemistry Letters. 2001 ; Vol. 11, No. 19. pp. 2659-2662.
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