Abstract
For the development of new anticancer agents, 2,2′:6′,2″-, 2,2′:6′,3″- and 2,2′:6′,4″-terpyridine derivatives were designed and evaluated for their topoisomerase I inhibitory activity and antitumor cytotoxicity. Structure-activity relationship studies indicated that 2,2′:6′,2″-terpyridine derivatives were highly cytotoxic toward several human tumor cell lines, whereas 2,2′:6′,3″- and 2,2′:6′,4″-terpyridine derivatives were potent topoisomerase I inhibitors.
| Original language | English |
|---|---|
| Pages (from-to) | 2659-2662 |
| Number of pages | 4 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 11 |
| Issue number | 19 |
| DOIs | |
| Publication status | Published - 2001 Oct 8 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Organic Chemistry
- Drug Discovery
- Pharmaceutical Science
Cite this
Synthesis, topoisomerase I inhibition and antitumor cytotoxicity of 2,2′ : 6′,2″-, 2,2′:6′,3″- and 2,2′:6′,4″-terpyridine derivatives. / Zhao, Long Xuan; Kim, Tae Sung; Ahn, Soo Hyun; Kim, Tae Hyung; Kim, Eun kyung; Cho, Won Jea; Choi, Heesung; Lee, Chong Soon; Kim, Jung Ae; Jeong, Tae Cheon; Chang, Ching jer; Lee, Eung Seok.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 11, No. 19, 08.10.2001, p. 2659-2662.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synthesis, topoisomerase I inhibition and antitumor cytotoxicity of 2,2′
T2 - 6′,2″-, 2,2′:6′,3″- and 2,2′:6′,4″-terpyridine derivatives
AU - Zhao, Long Xuan
AU - Kim, Tae Sung
AU - Ahn, Soo Hyun
AU - Kim, Tae Hyung
AU - Kim, Eun kyung
AU - Cho, Won Jea
AU - Choi, Heesung
AU - Lee, Chong Soon
AU - Kim, Jung Ae
AU - Jeong, Tae Cheon
AU - Chang, Ching jer
AU - Lee, Eung Seok
PY - 2001/10/8
Y1 - 2001/10/8
N2 - For the development of new anticancer agents, 2,2′:6′,2″-, 2,2′:6′,3″- and 2,2′:6′,4″-terpyridine derivatives were designed and evaluated for their topoisomerase I inhibitory activity and antitumor cytotoxicity. Structure-activity relationship studies indicated that 2,2′:6′,2″-terpyridine derivatives were highly cytotoxic toward several human tumor cell lines, whereas 2,2′:6′,3″- and 2,2′:6′,4″-terpyridine derivatives were potent topoisomerase I inhibitors.
AB - For the development of new anticancer agents, 2,2′:6′,2″-, 2,2′:6′,3″- and 2,2′:6′,4″-terpyridine derivatives were designed and evaluated for their topoisomerase I inhibitory activity and antitumor cytotoxicity. Structure-activity relationship studies indicated that 2,2′:6′,2″-terpyridine derivatives were highly cytotoxic toward several human tumor cell lines, whereas 2,2′:6′,3″- and 2,2′:6′,4″-terpyridine derivatives were potent topoisomerase I inhibitors.
UR - http://www.scopus.com/inward/record.url?scp=0035829148&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035829148&partnerID=8YFLogxK
U2 - 10.1016/S0960-894X(01)00531-5
DO - 10.1016/S0960-894X(01)00531-5
M3 - Article
C2 - 11551772
AN - SCOPUS:0035829148
VL - 11
SP - 2659
EP - 2662
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 19
ER -