TY - JOUR
T1 - Synthesis, topoisomerase I inhibition and antitumor cytotoxicity of 2,2′:6′,2″-, 2,2′:6′,3″- and 2,2′:6′,4″-terpyridine derivatives
AU - Zhao, Long Xuan
AU - Kim, Tae Sung
AU - Ahn, Soo Hyun
AU - Kim, Tae Hyung
AU - Kim, Eun kyung
AU - Cho, Won Jea
AU - Choi, Heesung
AU - Lee, Chong Soon
AU - Kim, Jung Ae
AU - Jeong, Tae Cheon
AU - Chang, Ching jer
AU - Lee, Eung Seok
N1 - Funding Information:
This work was supported by a grant (HMP-00-B-21500-0110) from the Ministry of Health and Welfare, R.O.K.
Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 2001/10/8
Y1 - 2001/10/8
N2 - For the development of new anticancer agents, 2,2′:6′,2″-, 2,2′:6′,3″- and 2,2′:6′,4″-terpyridine derivatives were designed and evaluated for their topoisomerase I inhibitory activity and antitumor cytotoxicity. Structure-activity relationship studies indicated that 2,2′:6′,2″-terpyridine derivatives were highly cytotoxic toward several human tumor cell lines, whereas 2,2′:6′,3″- and 2,2′:6′,4″-terpyridine derivatives were potent topoisomerase I inhibitors.
AB - For the development of new anticancer agents, 2,2′:6′,2″-, 2,2′:6′,3″- and 2,2′:6′,4″-terpyridine derivatives were designed and evaluated for their topoisomerase I inhibitory activity and antitumor cytotoxicity. Structure-activity relationship studies indicated that 2,2′:6′,2″-terpyridine derivatives were highly cytotoxic toward several human tumor cell lines, whereas 2,2′:6′,3″- and 2,2′:6′,4″-terpyridine derivatives were potent topoisomerase I inhibitors.
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U2 - 10.1016/S0960-894X(01)00531-5
DO - 10.1016/S0960-894X(01)00531-5
M3 - Article
C2 - 11551772
AN - SCOPUS:0035829148
VL - 11
SP - 2659
EP - 2662
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 19
ER -