Abstract
For the development of new anticancer agents, 2,2′:6′,2″-, 2,2′:6′,3″- and 2,2′:6′,4″-terpyridine derivatives were designed and evaluated for their topoisomerase I inhibitory activity and antitumor cytotoxicity. Structure-activity relationship studies indicated that 2,2′:6′,2″-terpyridine derivatives were highly cytotoxic toward several human tumor cell lines, whereas 2,2′:6′,3″- and 2,2′:6′,4″-terpyridine derivatives were potent topoisomerase I inhibitors.
| Original language | English |
|---|---|
| Pages (from-to) | 2659-2662 |
| Number of pages | 4 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 11 |
| Issue number | 19 |
| DOIs | |
| Publication status | Published - 2001 Oct 8 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry
Cite this
Zhao, L. X., Kim, T. S., Ahn, S. H., Kim, T. H., Kim, E. K., Cho, W. J., Choi, H., Lee, C. S., Kim, J. A., Jeong, T. C., Chang, C. J., & Lee, E. S. (2001). Synthesis, topoisomerase I inhibition and antitumor cytotoxicity of 2,2′:6′,2″-, 2,2′:6′,3″- and 2,2′:6′,4″-terpyridine derivatives. Bioorganic and Medicinal Chemistry Letters, 11(19), 2659-2662. https://doi.org/10.1016/S0960-894X(01)00531-5