Synthesis, topoisomerase I inhibition and antitumor cytotoxicity of 2,2′

6′,2″-, 2,2′:6′,3″- and 2,2′:6′,4″-terpyridine derivatives

Long Xuan Zhao, Tae Sung Kim, Soo Hyun Ahn, Tae Hyung Kim, Eun kyung Kim, Won Jea Cho, Heesung Choi, Chong Soon Lee, Jung Ae Kim, Tae Cheon Jeong, Ching jer Chang, Eung Seok Lee

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

For the development of new anticancer agents, 2,2′:6′,2″-, 2,2′:6′,3″- and 2,2′:6′,4″-terpyridine derivatives were designed and evaluated for their topoisomerase I inhibitory activity and antitumor cytotoxicity. Structure-activity relationship studies indicated that 2,2′:6′,2″-terpyridine derivatives were highly cytotoxic toward several human tumor cell lines, whereas 2,2′:6′,3″- and 2,2′:6′,4″-terpyridine derivatives were potent topoisomerase I inhibitors.

Original languageEnglish
Pages (from-to)2659-2662
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume11
Issue number19
DOIs
Publication statusPublished - 2001 Oct 8
Externally publishedYes

Fingerprint

Topoisomerase I Inhibitors
Type I DNA Topoisomerase
Structure-Activity Relationship
Cytotoxicity
Tumor Cell Line
Antineoplastic Agents
Derivatives
Tumors
Cells

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Synthesis, topoisomerase I inhibition and antitumor cytotoxicity of 2,2′ : 6′,2″-, 2,2′:6′,3″- and 2,2′:6′,4″-terpyridine derivatives. / Zhao, Long Xuan; Kim, Tae Sung; Ahn, Soo Hyun; Kim, Tae Hyung; Kim, Eun kyung; Cho, Won Jea; Choi, Heesung; Lee, Chong Soon; Kim, Jung Ae; Jeong, Tae Cheon; Chang, Ching jer; Lee, Eung Seok.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 11, No. 19, 08.10.2001, p. 2659-2662.

Research output: Contribution to journalArticle

Zhao, Long Xuan ; Kim, Tae Sung ; Ahn, Soo Hyun ; Kim, Tae Hyung ; Kim, Eun kyung ; Cho, Won Jea ; Choi, Heesung ; Lee, Chong Soon ; Kim, Jung Ae ; Jeong, Tae Cheon ; Chang, Ching jer ; Lee, Eung Seok. / Synthesis, topoisomerase I inhibition and antitumor cytotoxicity of 2,2′ : 6′,2″-, 2,2′:6′,3″- and 2,2′:6′,4″-terpyridine derivatives. In: Bioorganic and Medicinal Chemistry Letters. 2001 ; Vol. 11, No. 19. pp. 2659-2662.
@article{ce9e475d0b174cf18e2d2978947b6743,
title = "Synthesis, topoisomerase I inhibition and antitumor cytotoxicity of 2,2′: 6′,2″-, 2,2′:6′,3″- and 2,2′:6′,4″-terpyridine derivatives",
abstract = "For the development of new anticancer agents, 2,2′:6′,2″-, 2,2′:6′,3″- and 2,2′:6′,4″-terpyridine derivatives were designed and evaluated for their topoisomerase I inhibitory activity and antitumor cytotoxicity. Structure-activity relationship studies indicated that 2,2′:6′,2″-terpyridine derivatives were highly cytotoxic toward several human tumor cell lines, whereas 2,2′:6′,3″- and 2,2′:6′,4″-terpyridine derivatives were potent topoisomerase I inhibitors.",
author = "Zhao, {Long Xuan} and Kim, {Tae Sung} and Ahn, {Soo Hyun} and Kim, {Tae Hyung} and Kim, {Eun kyung} and Cho, {Won Jea} and Heesung Choi and Lee, {Chong Soon} and Kim, {Jung Ae} and Jeong, {Tae Cheon} and Chang, {Ching jer} and Lee, {Eung Seok}",
year = "2001",
month = "10",
day = "8",
doi = "10.1016/S0960-894X(01)00531-5",
language = "English",
volume = "11",
pages = "2659--2662",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "19",

}

TY - JOUR

T1 - Synthesis, topoisomerase I inhibition and antitumor cytotoxicity of 2,2′

T2 - 6′,2″-, 2,2′:6′,3″- and 2,2′:6′,4″-terpyridine derivatives

AU - Zhao, Long Xuan

AU - Kim, Tae Sung

AU - Ahn, Soo Hyun

AU - Kim, Tae Hyung

AU - Kim, Eun kyung

AU - Cho, Won Jea

AU - Choi, Heesung

AU - Lee, Chong Soon

AU - Kim, Jung Ae

AU - Jeong, Tae Cheon

AU - Chang, Ching jer

AU - Lee, Eung Seok

PY - 2001/10/8

Y1 - 2001/10/8

N2 - For the development of new anticancer agents, 2,2′:6′,2″-, 2,2′:6′,3″- and 2,2′:6′,4″-terpyridine derivatives were designed and evaluated for their topoisomerase I inhibitory activity and antitumor cytotoxicity. Structure-activity relationship studies indicated that 2,2′:6′,2″-terpyridine derivatives were highly cytotoxic toward several human tumor cell lines, whereas 2,2′:6′,3″- and 2,2′:6′,4″-terpyridine derivatives were potent topoisomerase I inhibitors.

AB - For the development of new anticancer agents, 2,2′:6′,2″-, 2,2′:6′,3″- and 2,2′:6′,4″-terpyridine derivatives were designed and evaluated for their topoisomerase I inhibitory activity and antitumor cytotoxicity. Structure-activity relationship studies indicated that 2,2′:6′,2″-terpyridine derivatives were highly cytotoxic toward several human tumor cell lines, whereas 2,2′:6′,3″- and 2,2′:6′,4″-terpyridine derivatives were potent topoisomerase I inhibitors.

UR - http://www.scopus.com/inward/record.url?scp=0035829148&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035829148&partnerID=8YFLogxK

U2 - 10.1016/S0960-894X(01)00531-5

DO - 10.1016/S0960-894X(01)00531-5

M3 - Article

VL - 11

SP - 2659

EP - 2662

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 19

ER -