Synthetic bone mimetic matrix-mediated in situ bone tissue formation through host cell recruitment

Yu Ru Shih, Ameya Phadke, Tomonori Yamaguchi, Heemin Kang, Nozomu Inoue, Koichi Masuda, Shyni Varghese

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Advances in tissue engineering have offered new opportunities to restore anatomically and functionally compromised tissues. Although traditional tissue engineering approaches that utilize biomaterials and cells to create tissue constructs for implantation or biomaterials as a scaffold to deliver cells are promising, strategies that can activate endogenous cells to promote tissue repair are more clinically attractive. Here, we demonstrate that an engineered injectable matrix mimicking a calcium phosphate (CaP)-rich bone-specific microenvironment can recruit endogenous cells to form bone tissues in vivo. Comparison of matrix alone with that of bone marrow-soaked or bFGF-soaked matrix demonstrates similar extent of neo-bone formation and bridging of decorticated transverse processes in a posterolateral lumbar fusion rat model. Synthetic biomaterials that stimulate endogenous cells without the need for biologics to assist tissue repair could circumvent limitations associated with conventional tissue engineering approaches, including ex vivo cell processing and laborious efforts, thereby accelerating the translational aspects of regenerative medicine.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalActa Biomaterialia
Volume19
DOIs
Publication statusPublished - 2015 Jun 1
Externally publishedYes

Keywords

  • Biomimetic materials
  • Biomineralization
  • Bone grafts
  • Posterolateral fusion
  • Spine

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering
  • Molecular Biology

Fingerprint Dive into the research topics of 'Synthetic bone mimetic matrix-mediated in situ bone tissue formation through host cell recruitment'. Together they form a unique fingerprint.

  • Cite this