Systemic lupus erythematosus is a risk factor for cardiovascular disease: a nationwide, population-based study in Korea

S. Y. Lim, E. H. Bae, K. D. Han, J. H. Jung, H. S. Choi, H. Y. Kim, C. S. Kim, S. K. Ma, S. W. Kim

    Research output: Contribution to journalArticlepeer-review

    12 Citations (Scopus)


    Objective: To investigate the incidence and clinical significance of cardiovascular disease in systemic lupus erythematosus patients. Methods: We included systemic lupus erythematosus patients (n = 18,575) without previous cardiovascular disease and age- and sex-matched individuals without systemic lupus erythematosus (controls; n = 92,875) from the Korean National Health Insurance Service database (2008–2014). Both cohorts were followed up for incident cardiovascular disease and death until 2015. Results: During follow up, myocardial infarction occurred in 203 systemic lupus erythematosus patients and 325 controls (incidence rate: 1.76 and 0.56 per 1000 person-years, respectively), stroke occurred in 289 patients and 403 controls (incidence rate: 2.51 and 0.70 per 1000 person-years, respectively), heart failure occurred in 358 patients and 354 controls (incidence rate 3.11 and 0.61 per 1000 person-years, respectively), and death occurred in 744 patients and 948 controls (incidence rate 6.54 and 1.64 per 1000 person-years, respectively). Patients with systemic lupus erythematosus had higher risks for myocardial infarction (hazard ratio: 2.74, 95% confidence interval: 2.28–3.37), stroke (hazard ratio: 3.31, 95% confidence interval: 2.84–3.86), heart failure (hazard ratio: 4.60, 95% confidence interval: 3.96–5.35), and cardiac death (hazard ratio: 3.98, 95% confidence interval: 3.61–4.39). Conclusions: Here, systemic lupus erythematosus was an independent risk factor for cardiovascular disease, thus cardiac assessment and management are critical in systemic lupus erythematosus patients.

    Original languageEnglish
    Pages (from-to)2050-2056
    Number of pages7
    Issue number13
    Publication statusPublished - 2018 Nov 1


    • Systemic lupus erythematosus
    • cardiovascular disease
    • death
    • epidemiology
    • heart failure
    • myocardial infarction
    • stroke

    ASJC Scopus subject areas

    • Rheumatology


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