Systems and synthetic biology to elucidate secondary metabolite biosynthetic gene clusters encoded in: Streptomyces genomes

Namil Lee, Soonkyu Hwang, Woori Kim, Yongjae Lee, Ji Hun Kim, Suhyung Cho, Hyun Uk Kim, Yeo Joon Yoon, Min Kyu Oh, Bernhard O. Palsson, Byung Kwan Cho

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)

Abstract

Covering: 2010 to 2020 Over the last few decades, Streptomyces have been extensively investigated for their ability to produce diverse bioactive secondary metabolites. Recent advances in Streptomyces research have been largely supported by improvements in high-throughput technology 'omics'. From genomics, numerous secondary metabolite biosynthetic gene clusters were predicted, increasing their genomic potential for novel bioactive compound discovery. Additional omics, including transcriptomics, translatomics, interactomics, proteomics and metabolomics, have been applied to obtain a system-level understanding spanning entire bioprocesses of Streptomyces, revealing highly interconnected and multi-layered regulatory networks for secondary metabolism. The comprehensive understanding derived from this systematic information accelerates the rational engineering of Streptomyces to enhance secondary metabolite production, integrated with the exploitation of the highly efficient 'Design-Build-Test-Learn' cycle in synthetic biology. In this review, we describe the current status of omics applications in Streptomyces research to better understand the organism and exploit its genetic potential for higher production of valuable secondary metabolites and novel secondary metabolite discovery. This journal is

Original languageEnglish
Pages (from-to)1330-1361
Number of pages32
JournalNatural Product Reports
Volume38
Issue number7
DOIs
Publication statusPublished - 2021 Jul

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Systems and synthetic biology to elucidate secondary metabolite biosynthetic gene clusters encoded in: Streptomyces genomes'. Together they form a unique fingerprint.

Cite this