T-helper types 1, 2, and 3 cytokine interactions in symptomatic manic patients

Yong Ku Kim, Aye Mu Myint, Bun Hee Lee, Chang Su Han, Seung Whan Lee, Brian E. Leonard, Harry W.M. Steinbusch

    Research output: Contribution to journalArticlepeer-review

    82 Citations (Scopus)

    Abstract

    It has been reported that the balance between T-helper type 1 (Th1) cytokines and T-helper type 2 (Th2) cytokines plays a role in psychiatric disorders such as bipolar disorder. The T-helper type 3 (Th3) cytokine, which transforming growth factor beta-1 (TGF-β1), has been shown to modulate the production of Th1 and Th2 cytokines. However, the role of TGF-β1 in bipolar disorder has not yet been explored. A total of 70 manic patients with bipolar disorder and 96 normal controls was recruited. The plasma levels of IFN-γ, IL-4, and TGF-β1 were studied at the time of admission and 8 weeks after mood stabilizer treatment. The detection rate and plasma concentrations of IFN-γ and IL-4 and the IFN-γ/TGF-β1 and IL-4/TGF-β1 ratios were significantly higher in patients than in controls, while the TGF-β1 level was significantly lower. The TGF-β1 level increased significantly after treatment and the IFN-γ/TGF-β1 and IL-4/TGF-β1 ratios returned to control values. TGF-β1 may play a role in the pathophysiology of bipolar disorder through the action of TGF-β1 in modulating the IL-4/TGF-β1 ratio.

    Original languageEnglish
    Pages (from-to)267-272
    Number of pages6
    JournalPsychiatry Research
    Volume129
    Issue number3
    DOIs
    Publication statusPublished - 2004 Dec 30

    Keywords

    • Bipolar disorder
    • Cytokine
    • Interferon
    • Interleukin
    • Lithium
    • TGF

    ASJC Scopus subject areas

    • Psychiatry and Mental health
    • Biological Psychiatry

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