T-helper types 1, 2, and 3 cytokine interactions in symptomatic manic patients

Yong Ku Kim, Aye Mu Myint, Bun Hee Lee, Changsu Han, Seung Whan Lee, Brian E. Leonard, Harry W M Steinbusch

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

It has been reported that the balance between T-helper type 1 (Th1) cytokines and T-helper type 2 (Th2) cytokines plays a role in psychiatric disorders such as bipolar disorder. The T-helper type 3 (Th3) cytokine, which transforming growth factor beta-1 (TGF-β1), has been shown to modulate the production of Th1 and Th2 cytokines. However, the role of TGF-β1 in bipolar disorder has not yet been explored. A total of 70 manic patients with bipolar disorder and 96 normal controls was recruited. The plasma levels of IFN-γ, IL-4, and TGF-β1 were studied at the time of admission and 8 weeks after mood stabilizer treatment. The detection rate and plasma concentrations of IFN-γ and IL-4 and the IFN-γ/TGF-β1 and IL-4/TGF-β1 ratios were significantly higher in patients than in controls, while the TGF-β1 level was significantly lower. The TGF-β1 level increased significantly after treatment and the IFN-γ/TGF-β1 and IL-4/TGF-β1 ratios returned to control values. TGF-β1 may play a role in the pathophysiology of bipolar disorder through the action of TGF-β1 in modulating the IL-4/TGF-β1 ratio.

Original languageEnglish
Pages (from-to)267-272
Number of pages6
JournalPsychiatry Research
Volume129
Issue number3
DOIs
Publication statusPublished - 2004 Dec 30

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Transforming Growth Factor beta
Cytokines
Interleukin-4
Bipolar Disorder
Psychiatry

Keywords

  • Bipolar disorder
  • Cytokine
  • Interferon
  • Interleukin
  • Lithium
  • TGF

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

Cite this

Kim, Y. K., Myint, A. M., Lee, B. H., Han, C., Lee, S. W., Leonard, B. E., & Steinbusch, H. W. M. (2004). T-helper types 1, 2, and 3 cytokine interactions in symptomatic manic patients. Psychiatry Research, 129(3), 267-272. https://doi.org/10.1016/j.psychres.2004.08.005

T-helper types 1, 2, and 3 cytokine interactions in symptomatic manic patients. / Kim, Yong Ku; Myint, Aye Mu; Lee, Bun Hee; Han, Changsu; Lee, Seung Whan; Leonard, Brian E.; Steinbusch, Harry W M.

In: Psychiatry Research, Vol. 129, No. 3, 30.12.2004, p. 267-272.

Research output: Contribution to journalArticle

Kim, Yong Ku ; Myint, Aye Mu ; Lee, Bun Hee ; Han, Changsu ; Lee, Seung Whan ; Leonard, Brian E. ; Steinbusch, Harry W M. / T-helper types 1, 2, and 3 cytokine interactions in symptomatic manic patients. In: Psychiatry Research. 2004 ; Vol. 129, No. 3. pp. 267-272.
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