Target-controlled propofol infusion for sedation in patients undergoing transrectal ultrasound-guided prostate biopsy

J. Y. Park, S. J. Park, Sung Uk Choi, H. W. Shin, H. W. Lee, H. J. Lim, S. M. Yoon, S. H. Chang

    Research output: Contribution to journalArticlepeer-review

    9 Citations (Scopus)

    Abstract

    The efficacy and safety of the routine use of target-controlled infusion of propofol for the sedation of patients undergoing transrectal ultrasound-guided prostate biopsy were assessed. The optimal level of sedation was also evaluated. A total of 250 patients were randomized into five groups according to sedation level determined by the Observer's Assessment of Alertness/Sedation (OAA/S) scale. As the level of sedation was increased, the overall pain and discomfort score decreased and the satisfaction rate tended to: increase, although hypoxia meant that intervention occurred more frequently at higher sedation levels. Target-controlled infusion of propofol provided safe and effective sedation during transrectal ultrasound-guided prostate biopsy, particularly if moderate sedation (OAA/S score of 3) was achieved. The effect-site concentration of propofol for this level of sedation was about 1.5 μg/ml.

    Original languageEnglish
    Pages (from-to)773-780
    Number of pages8
    JournalJournal of International Medical Research
    Volume35
    Issue number6
    DOIs
    Publication statusPublished - 2007

    Keywords

    • Anaesthetic
    • Biopsy
    • Propofol
    • Prostate
    • Sedation
    • Ultrasonography

    ASJC Scopus subject areas

    • Biochemistry
    • Cell Biology
    • Biochemistry, medical

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