Target-organ damage and incident hypertension: The Korean genome and epidemiology study

Seong Hwan Kim, Yong Hyun Kim, Jin-Seok Kim, Sang Yeob Lim, Jae Hyun Jung, Hong Euy Lim, Eung Ju Kim, Goo Yeong Cho, Inkyung Baik, Ki Chul Sung, Juri Park, Seung Ku Lee, Chol Shin

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective: Hypertension is associated with cardiovascular organ damage. However, data are scanty on whether individual forms or combinations of subclinical target organ damage (TOD) increase the risk of incident hypertension in nonhypertensive study participants. Methods: A total of 1785 nonhypertensive participants from the fourth biennial examination (2007-2008) of the Korean Genome and Epidemiology Study were followed-up for four years. Echocardiographic left ventricular (LV) hypertrophy, LV diastolic dysfunction, increased carotid intima-media thickness (cIMT), and brachial-ankle pulse wave velocity (baPWV) were defined according to the current guidelines. Results: During 4-year follow-up, 19.9% of participants developed hypertension. In multivariate Cox proportional hazards models, the adjusted hazard ratios for developing hypertension were 1.39, 1.66, 1.48, and 0.78 for higher values of the LV mass index, cIMT, baPWV, and tissue Doppler e′ velocity, respectively (all P75th percentile, and baPWV ≥ 1400cm/s were 1.61, 1.30, 1.86, and 2.07, respectively (all P

Original languageEnglish
Pages (from-to)524-531
Number of pages8
JournalJournal of Hypertension
Volume34
Issue number3
DOIs
Publication statusPublished - 2016 Mar 1

Keywords

  • carotid intima-media thickness
  • diastolic function
  • hypertension
  • left ventricular hypertrophy
  • pulse wave velocity
  • target organ damage

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

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