Abstract
BONE marrow progenitor cells have been shown to contribute to a small proportion of cells in nonhematopoietic tissues including the brain. In the acute unilateral middle cerebral artery occlusion model in spontaneously hypertensive rats following male-to-female bone marrow transplantation, we present data suggesting that 55% more marrow-derived cells, in general, and 161% more GFAP-positive astrocytes, in particular, migrate preferentially to the ischemic cortex than to the contralateral non-ischemic hemisphere. In addition to their biological significance, our findings could have therapeutic implications. Marrow-derived progenitor cells could potentially be used as vehicles for ex vivo gene transfer to the brain.
| Original language | English |
|---|---|
| Pages (from-to) | 1289-1292 |
| Number of pages | 4 |
| Journal | NeuroReport |
| Volume | 10 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 1999 Apr 26 |
| Externally published | Yes |
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Keywords
- Astrocyte
- Bone marrow
- Brain
- Fluorescent in situ hybridization
- Ischemia
- Transplantation
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Targeting of marrow-derived astrocytes to the ischemic brain. / Eglitis, Martin A.; Dawson, Debbie; Park, Kun Woo; Mouradian, M. Maral.
In: NeuroReport, Vol. 10, No. 6, 26.04.1999, p. 1289-1292.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Targeting of marrow-derived astrocytes to the ischemic brain
AU - Eglitis, Martin A.
AU - Dawson, Debbie
AU - Park, Kun Woo
AU - Mouradian, M. Maral
PY - 1999/4/26
Y1 - 1999/4/26
N2 - BONE marrow progenitor cells have been shown to contribute to a small proportion of cells in nonhematopoietic tissues including the brain. In the acute unilateral middle cerebral artery occlusion model in spontaneously hypertensive rats following male-to-female bone marrow transplantation, we present data suggesting that 55% more marrow-derived cells, in general, and 161% more GFAP-positive astrocytes, in particular, migrate preferentially to the ischemic cortex than to the contralateral non-ischemic hemisphere. In addition to their biological significance, our findings could have therapeutic implications. Marrow-derived progenitor cells could potentially be used as vehicles for ex vivo gene transfer to the brain.
AB - BONE marrow progenitor cells have been shown to contribute to a small proportion of cells in nonhematopoietic tissues including the brain. In the acute unilateral middle cerebral artery occlusion model in spontaneously hypertensive rats following male-to-female bone marrow transplantation, we present data suggesting that 55% more marrow-derived cells, in general, and 161% more GFAP-positive astrocytes, in particular, migrate preferentially to the ischemic cortex than to the contralateral non-ischemic hemisphere. In addition to their biological significance, our findings could have therapeutic implications. Marrow-derived progenitor cells could potentially be used as vehicles for ex vivo gene transfer to the brain.
KW - Astrocyte
KW - Bone marrow
KW - Brain
KW - Fluorescent in situ hybridization
KW - Ischemia
KW - Transplantation
UR - http://www.scopus.com/inward/record.url?scp=0033606069&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033606069&partnerID=8YFLogxK
U2 - 10.1097/00001756-199904260-00025
DO - 10.1097/00001756-199904260-00025
M3 - Article
C2 - 10363941
AN - SCOPUS:0033606069
VL - 10
SP - 1289
EP - 1292
JO - NeuroReport
JF - NeuroReport
SN - 0959-4965
IS - 6
ER -