Targeting of marrow-derived astrocytes to the ischemic brain

Martin A. Eglitis, Debbie Dawson, Kun Woo Park, M. Maral Mouradian

Research output: Contribution to journalArticle

130 Citations (Scopus)

Abstract

BONE marrow progenitor cells have been shown to contribute to a small proportion of cells in nonhematopoietic tissues including the brain. In the acute unilateral middle cerebral artery occlusion model in spontaneously hypertensive rats following male-to-female bone marrow transplantation, we present data suggesting that 55% more marrow-derived cells, in general, and 161% more GFAP-positive astrocytes, in particular, migrate preferentially to the ischemic cortex than to the contralateral non-ischemic hemisphere. In addition to their biological significance, our findings could have therapeutic implications. Marrow-derived progenitor cells could potentially be used as vehicles for ex vivo gene transfer to the brain.

Original languageEnglish
Pages (from-to)1289-1292
Number of pages4
JournalNeuroreport
Volume10
Issue number6
DOIs
Publication statusPublished - 1999 Apr 26
Externally publishedYes

Keywords

  • Astrocyte
  • Bone marrow
  • Brain
  • Fluorescent in situ hybridization
  • Ischemia
  • Transplantation

ASJC Scopus subject areas

  • Neuroscience(all)

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  • Cite this

    Eglitis, M. A., Dawson, D., Park, K. W., & Mouradian, M. M. (1999). Targeting of marrow-derived astrocytes to the ischemic brain. Neuroreport, 10(6), 1289-1292. https://doi.org/10.1097/00001756-199904260-00025