Abstract
BONE marrow progenitor cells have been shown to contribute to a small proportion of cells in nonhematopoietic tissues including the brain. In the acute unilateral middle cerebral artery occlusion model in spontaneously hypertensive rats following male-to-female bone marrow transplantation, we present data suggesting that 55% more marrow-derived cells, in general, and 161% more GFAP-positive astrocytes, in particular, migrate preferentially to the ischemic cortex than to the contralateral non-ischemic hemisphere. In addition to their biological significance, our findings could have therapeutic implications. Marrow-derived progenitor cells could potentially be used as vehicles for ex vivo gene transfer to the brain.
| Original language | English |
|---|---|
| Pages (from-to) | 1289-1292 |
| Number of pages | 4 |
| Journal | Neuroreport |
| Volume | 10 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 1999 Apr 26 |
| Externally published | Yes |
Keywords
- Astrocyte
- Bone marrow
- Brain
- Fluorescent in situ hybridization
- Ischemia
- Transplantation
ASJC Scopus subject areas
- Neuroscience(all)
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Cite this
Eglitis, M. A., Dawson, D., Park, K. W., & Mouradian, M. M. (1999). Targeting of marrow-derived astrocytes to the ischemic brain. Neuroreport, 10(6), 1289-1292. https://doi.org/10.1097/00001756-199904260-00025