Targeting ROR1 inhibits the self-renewal and invasive ability of glioblastoma stem cells

Eun Hwa Jung, Han Na Lee, Gi Yeon Han, Min Jung Kim, Chan Wha Kim

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Glioblastoma is the most malignant of brain tumours and is difficult to cure because of interruption of drug delivery by the blood-brain barrier system, its high metastatic capacity and the existence of cancer stem cells (CSCs). Although CSCs are present as a small population in malignant tumours, CSCs have been studied as they are responsible for causing recurrence, metastasis and resistance to chemotherapy and radiotherapy for cancer. CSCs have self-renewal characteristics like normal stem cells. The aim of this study was to investigate whether receptor tyrosine kinase-like orphan receptor 1 (ROR1) is involved in stem cell maintenance and malignant properties in human glioblastoma. Knockdown of ROR1 caused reduction of stemness and sphere formation capacity. Moreover, down-regulation of ROR1 suppressed the expression of epithelial-mesenchymal transition-related genes and the tumour migratory and invasive abilities. The results of this study indicate that targeting ROR1 can induce differentiation of CSCs and inhibit metastasis in glioblastoma. In addition, ROR1 may be used as a potential marker for glioblastoma stem cells as well as a potential target for glioblastoma stem cell therapy.

Original languageEnglish
JournalCell Biochemistry and Function
DOIs
Publication statusAccepted/In press - 2016

Fingerprint

Neoplastic Stem Cells
Glioblastoma
Stem cells
Stem Cells
Receptor Tyrosine Kinase-like Orphan Receptors
Tumors
Neoplasm Metastasis
Epithelial-Mesenchymal Transition
Cell- and Tissue-Based Therapy
Blood-Brain Barrier
Brain Neoplasms
Neoplasms
Chemotherapy
Radiotherapy
Down-Regulation
Maintenance
Drug delivery
Recurrence
Drug Therapy
Brain

Keywords

  • Glioblastoma stem cells
  • Invasion
  • Migration
  • ROR1
  • Stemness

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Clinical Biochemistry

Cite this

Targeting ROR1 inhibits the self-renewal and invasive ability of glioblastoma stem cells. / Jung, Eun Hwa; Lee, Han Na; Han, Gi Yeon; Kim, Min Jung; Kim, Chan Wha.

In: Cell Biochemistry and Function, 2016.

Research output: Contribution to journalArticle

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