Targeting the Hepatocyte Growth Factor and c-Met Signaling Axis in Bone Metastases

Young Mi Whang, Seung Pil Jung, Meyoung-Kon Kim, In Ho Chang, Serkin Park

Research output: Contribution to journalReview article

Abstract

Bone metastasis is the terminal stage disease of prostate, breast, renal, and lung cancers, and currently no therapeutic approach effectively cures or prevents its progression to bone metastasis. One of the hurdles to the development of new drugs for bone metastasis is the complexity and heterogeneity of the cellular components in the metastatic bone microenvironment. For example, bone cells, including osteoblasts, osteoclasts, and osteocytes, and the bone marrow cells of diverse hematopoietic lineages interact with each other via numerous cytokines and receptors. c-Met tyrosine kinase receptor and its sole ligand hepatocyte growth factor (HGF) are enriched in the bone microenvironment, and their expression correlates with the progression of bone metastasis. However, no drugs or antibodies targeting the c-Met/HGF signaling axis are currently available in bone metastatic patients. This significant discrepancy should be overcome by further investigation of the roles and regulation of c-Met and HGF in the metastatic bone microenvironment. This review paper summarizes the key findings of c-Met and HGF in the development of novel therapeutic approaches for bone metastasis.

Original languageEnglish
JournalInternational Journal of Molecular Sciences
Volume20
Issue number2
DOIs
Publication statusPublished - 2019 Jan 17

Fingerprint

Hepatocyte Growth Factor
metastasis
bones
Bone
Neoplasm Metastasis
Bone and Bones
progressions
drugs
Intercellular Signaling Peptides and Proteins
Hepatocytes
Proto-Oncogene Proteins c-met
Osteocytes
osteoblasts
Cytokine Receptors
bone marrow
Kidney Neoplasms
tyrosine
Osteoclasts
Osteoblasts
antibodies

Keywords

  • bone
  • bone marrow
  • c-Met and hepatocyte growth factor
  • metastasis
  • microenvironment
  • osteoblasts
  • osteoclasts

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Targeting the Hepatocyte Growth Factor and c-Met Signaling Axis in Bone Metastases. / Whang, Young Mi; Jung, Seung Pil; Kim, Meyoung-Kon; Chang, In Ho; Park, Serkin.

In: International Journal of Molecular Sciences, Vol. 20, No. 2, 17.01.2019.

Research output: Contribution to journalReview article

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