Tartary Buckwheat Extract Attenuated the Obesity-Induced Inflammation and Increased Muscle PGC-1a/SIRT1 Expression in High Fat Diet-Induced Obese Rats

Seog Young Kim, Mak Soon Lee, Eugene Chang, Sunyoon Jung, Hyunmi Ko, Eunyoung Lee, Soojin Lee, Chong Tai Kim, In-Hwan Kim, Yangha Kim

Research output: Contribution to journalArticle

Abstract

Obesity is intimately related to a chronic inflammatory state, with augmentation of macrophage infiltration and pro-inflammatory cytokine secretion in white adipose tissue (WAT) and mitochondrial dysfunction in skeletal muscle. The specific aim of this study is to evaluate effects of tartary buckwheat extract (TB) on obesity-induced adipose tissue inflammation and muscle peroxisome proliferator-activated receptor-γ coactivator (PGC)-1α/sirtulin 1 (SIRT1) pathway in rats fed a high-fat diet. Sprague-Dawley rats were divided into four groups and fed either a normal diet (NOR), 45% high-fat diet (HF), HF + low dose of TB (TB-L; 5 g/kg diet), or HF + high dose of TB (TB-H; 10 g/kg diet) for 13 weeks. TB significantly reduced adipose tissue mass with decreased adipogenic gene expression of PPAR-γ and aP2. Serum nitric oxide levels and adipose tissue macrophage M1 polarization gene markers, such as iNOS, CD11c, and Arg1, and pro-inflammatory gene expression, including TNF-α, IL-6, and MCP-1, were remarkably downregulated in the TB-L and TB-H groups. Moreover, TB supplementation increased gene expression of PGC-1α and SIRT1, involved in muscle biogenesis and function. These results suggested that TB might attenuate obesity-induced inflammation and mitochondrial dysfunction by modulating adipose tissue inflammation and the muscle PGC-1α/SIRT1 pathway.

Original languageEnglish
JournalNutrients
Volume11
Issue number3
DOIs
Publication statusPublished - 2019 Mar 18

Fingerprint

Fagopyrum
buckwheat
High Fat Diet
high fat diet
obesity
Obesity
inflammation
Inflammation
Muscles
muscles
rats
extracts
adipose tissue
Adipose Tissue
Peroxisome Proliferator-Activated Receptors
Diet
Gene Expression
gene expression
macrophages
Macrophages

Keywords

  • adipose tissue macrophage
  • inflammation
  • obesity
  • PGC-1α
  • SIRT1
  • skeletal muscle
  • tartary buckwheat extract

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this

Tartary Buckwheat Extract Attenuated the Obesity-Induced Inflammation and Increased Muscle PGC-1a/SIRT1 Expression in High Fat Diet-Induced Obese Rats. / Kim, Seog Young; Lee, Mak Soon; Chang, Eugene; Jung, Sunyoon; Ko, Hyunmi; Lee, Eunyoung; Lee, Soojin; Kim, Chong Tai; Kim, In-Hwan; Kim, Yangha.

In: Nutrients, Vol. 11, No. 3, 18.03.2019.

Research output: Contribution to journalArticle

Kim, Seog Young ; Lee, Mak Soon ; Chang, Eugene ; Jung, Sunyoon ; Ko, Hyunmi ; Lee, Eunyoung ; Lee, Soojin ; Kim, Chong Tai ; Kim, In-Hwan ; Kim, Yangha. / Tartary Buckwheat Extract Attenuated the Obesity-Induced Inflammation and Increased Muscle PGC-1a/SIRT1 Expression in High Fat Diet-Induced Obese Rats. In: Nutrients. 2019 ; Vol. 11, No. 3.
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AU - Lee, Mak Soon

AU - Chang, Eugene

AU - Jung, Sunyoon

AU - Ko, Hyunmi

AU - Lee, Eunyoung

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AU - Kim, Chong Tai

AU - Kim, In-Hwan

AU - Kim, Yangha

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