Taurine depletion by β-alanine inhibits induction of hepatotoxicity in mice treated acutely with carbon tetrachloride

Dalwoong Choi, Sun Ju Kim, Do Young Kwon, Sun Young Lee, Young Chul Kim

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

We examined the effect of taurine depletion on hepatic sulfur-containing amino acid metabolism and carbon tetrachloride-induced acute liver injury. Mice were supplemented with β-alanine (3%) in drinking water for one week. β-Alanine intake significantly reduced hepatic taurine levels, but did not influence S-adenosylmethionine, S-adenosylhomocysteine, glutathione levels or methionine adenosyltransferase activity in liver. However, hepatic cysteine levels were significantly elevated by β-alanine administration. Hepatotoxicity caused by carbon tetrachloride (50 μ l/kg, ip) in mice fed β-alanine was decreased, as determined by changes in serum aspartate aminotransferase, alanine aminotransferase and sorbitol dehydrogenase activities. Hepatic glutathione and taurine levels after a carbon tetrachloride challenge were markedly increased by β-alanine exposure. The results suggest that enhanced availability of cysteine for synthesis of glutathione and/or taurine may account for the hepatoprotective effects of β-alanine against carbon tetrachloride-induced acute liver injury.

Original languageEnglish
Title of host publicationTaurine 7
EditorsJunichi Azuma, Ito Takashi, Stephen Schaffer
Pages305-311
Number of pages7
DOIs
Publication statusPublished - 2009

Publication series

NameAdvances in Experimental Medicine and Biology
Volume643
ISSN (Print)0065-2598

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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