Taurine depletion by β-alanine inhibits induction of hepatotoxicity in mice treated acutely with carbon tetrachloride

DalWoong Choi, Sun Ju Kim, Do Young Kwon, Sun Young Lee, Young Chul Kim

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

We examined the effect of taurine depletion on hepatic sulfur-containing amino acid metabolism and carbon tetrachloride-induced acute liver injury. Mice were supplemented with β-alanine (3%) in drinking water for one week. β-Alanine intake significantly reduced hepatic taurine levels, but did not influence S-adenosylmethionine, S-adenosylhomocysteine, glutathione levels or methionine adenosyltransferase activity in liver. However, hepatic cysteine levels were significantly elevated by β-alanine administration. Hepatotoxicity caused by carbon tetrachloride (50 μ l/kg, ip) in mice fed β-alanine was decreased, as determined by changes in serum aspartate aminotransferase, alanine aminotransferase and sorbitol dehydrogenase activities. Hepatic glutathione and taurine levels after a carbon tetrachloride challenge were markedly increased by β-alanine exposure. The results suggest that enhanced availability of cysteine for synthesis of glutathione and/or taurine may account for the hepatoprotective effects of β-alanine against carbon tetrachloride-induced acute liver injury.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
Pages305-311
Number of pages7
Volume643
DOIs
Publication statusPublished - 2009 Apr 22

Publication series

NameAdvances in Experimental Medicine and Biology
Volume643
ISSN (Print)00652598

Fingerprint

Carbon Tetrachloride
Taurine
Alanine
Liver
Glutathione
Cysteine
Methionine Adenosyltransferase
S-Adenosylhomocysteine
L-Iditol 2-Dehydrogenase
Alanine Dehydrogenase
S-Adenosylmethionine
Sulfur Amino Acids
Aspartate Aminotransferases
Alanine Transaminase
Sulfur
Metabolism
Drinking Water
Wounds and Injuries
Availability
Amino Acids

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Choi, D., Kim, S. J., Kwon, D. Y., Lee, S. Y., & Kim, Y. C. (2009). Taurine depletion by β-alanine inhibits induction of hepatotoxicity in mice treated acutely with carbon tetrachloride. In Advances in Experimental Medicine and Biology (Vol. 643, pp. 305-311). (Advances in Experimental Medicine and Biology; Vol. 643). https://doi.org/10.1007/978-0-387-75681-3_31

Taurine depletion by β-alanine inhibits induction of hepatotoxicity in mice treated acutely with carbon tetrachloride. / Choi, DalWoong; Kim, Sun Ju; Kwon, Do Young; Lee, Sun Young; Kim, Young Chul.

Advances in Experimental Medicine and Biology. Vol. 643 2009. p. 305-311 (Advances in Experimental Medicine and Biology; Vol. 643).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Choi, D, Kim, SJ, Kwon, DY, Lee, SY & Kim, YC 2009, Taurine depletion by β-alanine inhibits induction of hepatotoxicity in mice treated acutely with carbon tetrachloride. in Advances in Experimental Medicine and Biology. vol. 643, Advances in Experimental Medicine and Biology, vol. 643, pp. 305-311. https://doi.org/10.1007/978-0-387-75681-3_31
Choi D, Kim SJ, Kwon DY, Lee SY, Kim YC. Taurine depletion by β-alanine inhibits induction of hepatotoxicity in mice treated acutely with carbon tetrachloride. In Advances in Experimental Medicine and Biology. Vol. 643. 2009. p. 305-311. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-0-387-75681-3_31
Choi, DalWoong ; Kim, Sun Ju ; Kwon, Do Young ; Lee, Sun Young ; Kim, Young Chul. / Taurine depletion by β-alanine inhibits induction of hepatotoxicity in mice treated acutely with carbon tetrachloride. Advances in Experimental Medicine and Biology. Vol. 643 2009. pp. 305-311 (Advances in Experimental Medicine and Biology).
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