TAZ stimulates liver regeneration through interleukin-6-induced hepatocyte proliferation and inhibition of cell death after liver injury

A. Rum Kim, Jung Il Park, Ho Taek Oh, Kyung Min Kim, Jun Ha Hwang, Mi Gyeong Jeong, Ee Hyun Kim, Eun Sook Hwang, Jeong-Ho Hong

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In response to liver injury, the liver undergoes a regeneration process to retain its mass and function. However, the regeneration mechanism has not been fully clarified. This study investigated the role of transcriptional coactivator with PDZ-binding motif (TAZ), a Hippo-signaling effector, in liver regeneration. We observed that TAZ stimulates liver regeneration after liver injury. After partial hepatectomy (PHx) or carbon tetrachloride damage, TAZ was required for liver regeneration to increase hepatic cell proliferation and resist hepatic apoptosis, which were decreased in liver-specific TAZ knockout (LKO) mice. TAZ stimulated macrophage infiltration, resulting in IL-6 production, which induced liver regeneration. In LKO mice, IL-6-induced activation of signal transducer and activator of transcription 3, ERK, and PKB was decreased. We also observed that periductal fibrogenesis was significantly increased in LKO mice during liver regeneration after PHx, which was caused by increased hepatic apoptosis. Our results suggest that TAZ stimulates liver regeneration through IL-6-induced hepatocyte proliferation and inhibition of cell death after liver injury.-Kim, A. R., Park, J. I., Oh, H. T., Kim, K. M., Hwang, J.-H., Jeong, M. G., Kim, E.-H., Hwang, E. S., Hong, J.-H. TAZ stimulates liver regeneration through interleukin-6-induced hepatocyte proliferation and inhibition of cell death after liver injury.

Original languageEnglish
Pages (from-to)5914-5923
Number of pages10
JournalFASEB journal : official publication of the Federation of American Societies for Experimental Biology
Volume33
Issue number5
DOIs
Publication statusPublished - 2019 May 1

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Liver Regeneration
Cell death
Liver
Hepatocytes
Interleukin-6
Cell Death
Wounds and Injuries
Knockout Mice
Regeneration
Apoptosis
STAT3 Transcription Factor
Carbon Tetrachloride
Hepatectomy
Macrophages
Cell Proliferation
Cell proliferation
Infiltration

Keywords

  • CCl
  • cytokine
  • fibrogenesis
  • partial hepatectomy

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics

Cite this

TAZ stimulates liver regeneration through interleukin-6-induced hepatocyte proliferation and inhibition of cell death after liver injury. / Kim, A. Rum; Park, Jung Il; Oh, Ho Taek; Kim, Kyung Min; Hwang, Jun Ha; Jeong, Mi Gyeong; Kim, Ee Hyun; Hwang, Eun Sook; Hong, Jeong-Ho.

In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 33, No. 5, 01.05.2019, p. 5914-5923.

Research output: Contribution to journalArticle

Kim, A. Rum ; Park, Jung Il ; Oh, Ho Taek ; Kim, Kyung Min ; Hwang, Jun Ha ; Jeong, Mi Gyeong ; Kim, Ee Hyun ; Hwang, Eun Sook ; Hong, Jeong-Ho. / TAZ stimulates liver regeneration through interleukin-6-induced hepatocyte proliferation and inhibition of cell death after liver injury. In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019 ; Vol. 33, No. 5. pp. 5914-5923.
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