Tcf3 function is required for the inhibition of oligodendroglial fate specification in the spinal cord of zebrafish embryos

Suhyun Kim, Ah Young Chung, Dohyun Kim, Young Seop Kim, Hyung Seok Kim, Hyung Wook Kwon, Tae Lin Huh, Hae Chul Park

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The generation of various subtypes of neurons and glial cells at the right time and place is crucial for the proper development of the vertebrate CNS. Although the mechanisms and factors for the regulation of neuronal diversity in the CNS have been well studied, the mechanisms regulating the sequential production of neuronal and glial cells from neural precursors remain poorly understood. This study shows that Tcf3, a member of the Lef/Tcf family of proteins, is required to inhibit the premature oligodendroglial fate specification of spinal cord precursors using the transgenic zebrafish, which expresses a dominant repressor form of Tcf3 under the control of a heat-shock inducible promoter. In addition, the data revealed that Tcf3 function in oligodendroglial fate specification is mediated independently of canonical Wnt signaling. Altogether, these results show a novel function for Tcf3 in regulating the timing of oligodendroglial fate specification in the spinal cord.

Original languageEnglish
Pages (from-to)383-388
Number of pages6
JournalMolecules and cells
Volume32
Issue number4
DOIs
Publication statusPublished - 2011 Oct

Keywords

  • Neurogenesis
  • Oligodendrocytes
  • Spinal cord
  • Tcf3
  • Zebrafish

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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