TCTP protein degradation by targeting mTORC1 and signaling through S6K, Akt, and Plk1 sensitizes lung cancer cells to DNA-damaging drugs

Medicine & Life Sciences

• translationally-controlled 1 tumor protein 100%
• Mechanistic Target of Rapamycin Complex 1 77%
• Proteolysis 57%
• Lung Neoplasms 48%
• DNA 34%
• Pharmaceutical Preparations 25%
• Mechanistic Target of Rapamycin Complex 2 19%
• Sirolimus 14%
• Phosphorylation 9%
• A549 Cells 7%
• Ubiquitination 7%
• Proteasome Endopeptidase Complex 7%
• Ubiquitin 6%
• DNA Repair 6%
• Doxorubicin 6%
• Cisplatin 6%
• Heterografts 6%
• DNA Damage 5%
• Cell Death 5%
• Proteins 5%
• Neoplasms 4%
• Apoptosis 4%
• Messenger RNA 3%
• In Vitro Techniques 2%
• Therapeutics 1%