Technique for the early detection of drug-resistant HBV DNA during antiviral therapy

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Early detection of antiviral resistant mutants is of clinical importance in patients receiving antiviral treatment. The ideal assay is sensitive, specific, accurate, reproducible and easy to perform, attains a high throughput and is able to detect mixed and novel mutations. Advantages and disadvantages of sequencing, line probe assay, DNA chip technology, peptide nucleic acid cramping, fluorescent biprobe hybridization and a new technique based on matrix-assisted laser desorption/ionization time-of-flight mass-spectrometric analysis will be discussed.

Original languageEnglish
Pages (from-to)7-10
Number of pages4
JournalIntervirology
Volume51
Issue numberSUPPL. 1
DOIs
Publication statusPublished - 2008 Jun 1

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Antiviral Agents
Peptide Nucleic Acids
DNA
Oligonucleotide Array Sequence Analysis
Pharmaceutical Preparations
Lasers
Technology
Mutation
Therapeutics

Keywords

  • Antiviral drug resistance
  • HBV
  • Laser desorption/ionization
  • Mass spectrometry analysis
  • Resistant mutants

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

Cite this

Technique for the early detection of drug-resistant HBV DNA during antiviral therapy. / Yeon, Jong Eun.

In: Intervirology, Vol. 51, No. SUPPL. 1, 01.06.2008, p. 7-10.

Research output: Contribution to journalArticle

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