Abstract
Early detection of antiviral resistant mutants is of clinical importance in patients receiving antiviral treatment. The ideal assay is sensitive, specific, accurate, reproducible and easy to perform, attains a high throughput and is able to detect mixed and novel mutations. Advantages and disadvantages of sequencing, line probe assay, DNA chip technology, peptide nucleic acid cramping, fluorescent biprobe hybridization and a new technique based on matrix-assisted laser desorption/ionization time-of-flight mass-spectrometric analysis will be discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 7-10 |
| Number of pages | 4 |
| Journal | Intervirology |
| Volume | 51 |
| Issue number | SUPPL. 1 |
| DOIs | |
| Publication status | Published - 2008 Jun |
Keywords
- Antiviral drug resistance
- HBV
- Laser desorption/ionization
- Mass spectrometry analysis
- Resistant mutants
ASJC Scopus subject areas
- Virology
- Infectious Diseases
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Cite this
Yeon, J. E. (2008). Technique for the early detection of drug-resistant HBV DNA during antiviral therapy. Intervirology, 51(SUPPL. 1), 7-10. https://doi.org/10.1159/000122593