Technique for the early detection of drug-resistant HBV DNA during antiviral therapy

Jong Eun Yeon

doi:10.1159/000122593

Technique for the early detection of drug-resistant HBV DNA during antiviral therapy

Jong Eun Yeon

Department of Gastroenterology & Hepatology

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Early detection of antiviral resistant mutants is of clinical importance in patients receiving antiviral treatment. The ideal assay is sensitive, specific, accurate, reproducible and easy to perform, attains a high throughput and is able to detect mixed and novel mutations. Advantages and disadvantages of sequencing, line probe assay, DNA chip technology, peptide nucleic acid cramping, fluorescent biprobe hybridization and a new technique based on matrix-assisted laser desorption/ionization time-of-flight mass-spectrometric analysis will be discussed.

Original language	English
Pages (from-to)	7-10
Number of pages	4
Journal	Intervirology
Volume	51
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1159/000122593
Publication status	Published - 2008 Jun

Keywords

Antiviral drug resistance
HBV
Laser desorption/ionization
Mass spectrometry analysis
Resistant mutants

ASJC Scopus subject areas

Virology
Infectious Diseases

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

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10.1159/000122593

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AB - Early detection of antiviral resistant mutants is of clinical importance in patients receiving antiviral treatment. The ideal assay is sensitive, specific, accurate, reproducible and easy to perform, attains a high throughput and is able to detect mixed and novel mutations. Advantages and disadvantages of sequencing, line probe assay, DNA chip technology, peptide nucleic acid cramping, fluorescent biprobe hybridization and a new technique based on matrix-assisted laser desorption/ionization time-of-flight mass-spectrometric analysis will be discussed.

KW - Antiviral drug resistance

KW - HBV

KW - Laser desorption/ionization

KW - Mass spectrometry analysis

KW - Resistant mutants

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Technique for the early detection of drug-resistant HBV DNA during antiviral therapy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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