Technique for the early detection of drug-resistant HBV DNA during antiviral therapy

Jong Eun Yeon

doi:10.1159/000122593

Technique for the early detection of drug-resistant HBV DNA during antiviral therapy

Jong Eun Yeon

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Early detection of antiviral resistant mutants is of clinical importance in patients receiving antiviral treatment. The ideal assay is sensitive, specific, accurate, reproducible and easy to perform, attains a high throughput and is able to detect mixed and novel mutations. Advantages and disadvantages of sequencing, line probe assay, DNA chip technology, peptide nucleic acid cramping, fluorescent biprobe hybridization and a new technique based on matrix-assisted laser desorption/ionization time-of-flight mass-spectrometric analysis will be discussed.

Original language	English
Pages (from-to)	7-10
Number of pages	4
Journal	Intervirology
Volume	51
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1159/000122593
Publication status	Published - 2008 Jun
Externally published	Yes

Keywords

Antiviral drug resistance
HBV
Laser desorption/ionization
Mass spectrometry analysis
Resistant mutants

ASJC Scopus subject areas

Virology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1159/000122593

Cite this

@article{b242b56253a0460abc161f1b6c599730,

title = "Technique for the early detection of drug-resistant HBV DNA during antiviral therapy",

abstract = "Early detection of antiviral resistant mutants is of clinical importance in patients receiving antiviral treatment. The ideal assay is sensitive, specific, accurate, reproducible and easy to perform, attains a high throughput and is able to detect mixed and novel mutations. Advantages and disadvantages of sequencing, line probe assay, DNA chip technology, peptide nucleic acid cramping, fluorescent biprobe hybridization and a new technique based on matrix-assisted laser desorption/ionization time-of-flight mass-spectrometric analysis will be discussed.",

keywords = "Antiviral drug resistance, HBV, Laser desorption/ionization, Mass spectrometry analysis, Resistant mutants",

author = "Yeon, {Jong Eun}",

year = "2008",

month = jun,

doi = "10.1159/000122593",

language = "English",

volume = "51",

pages = "7--10",

journal = "Intervirology",

issn = "0300-5526",

publisher = "S. Karger AG",

number = "SUPPL. 1",

}

TY - JOUR

T1 - Technique for the early detection of drug-resistant HBV DNA during antiviral therapy

AU - Yeon, Jong Eun

PY - 2008/6

Y1 - 2008/6

N2 - Early detection of antiviral resistant mutants is of clinical importance in patients receiving antiviral treatment. The ideal assay is sensitive, specific, accurate, reproducible and easy to perform, attains a high throughput and is able to detect mixed and novel mutations. Advantages and disadvantages of sequencing, line probe assay, DNA chip technology, peptide nucleic acid cramping, fluorescent biprobe hybridization and a new technique based on matrix-assisted laser desorption/ionization time-of-flight mass-spectrometric analysis will be discussed.

AB - Early detection of antiviral resistant mutants is of clinical importance in patients receiving antiviral treatment. The ideal assay is sensitive, specific, accurate, reproducible and easy to perform, attains a high throughput and is able to detect mixed and novel mutations. Advantages and disadvantages of sequencing, line probe assay, DNA chip technology, peptide nucleic acid cramping, fluorescent biprobe hybridization and a new technique based on matrix-assisted laser desorption/ionization time-of-flight mass-spectrometric analysis will be discussed.

KW - Antiviral drug resistance

KW - HBV

KW - Laser desorption/ionization

KW - Mass spectrometry analysis

KW - Resistant mutants

UR - http://www.scopus.com/inward/record.url?scp=44949159715&partnerID=8YFLogxK

U2 - 10.1159/000122593

DO - 10.1159/000122593

M3 - Article

C2 - 18544942

AN - SCOPUS:44949159715

VL - 51

SP - 7

EP - 10

JO - Intervirology

JF - Intervirology

SN - 0300-5526

IS - SUPPL. 1

ER -

Technique for the early detection of drug-resistant HBV DNA during antiviral therapy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this