Abstract
Early detection of antiviral resistant mutants is of clinical importance in patients receiving antiviral treatment. The ideal assay is sensitive, specific, accurate, reproducible and easy to perform, attains a high throughput and is able to detect mixed and novel mutations. Advantages and disadvantages of sequencing, line probe assay, DNA chip technology, peptide nucleic acid cramping, fluorescent biprobe hybridization and a new technique based on matrix-assisted laser desorption/ionization time-of-flight mass-spectrometric analysis will be discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 7-10 |
| Number of pages | 4 |
| Journal | Intervirology |
| Volume | 51 |
| Issue number | SUPPL. 1 |
| DOIs | |
| Publication status | Published - 2008 Jun 1 |
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Keywords
- Antiviral drug resistance
- HBV
- Laser desorption/ionization
- Mass spectrometry analysis
- Resistant mutants
ASJC Scopus subject areas
- Infectious Diseases
- Virology
Cite this
Technique for the early detection of drug-resistant HBV DNA during antiviral therapy. / Yeon, Jong Eun.
In: Intervirology, Vol. 51, No. SUPPL. 1, 01.06.2008, p. 7-10.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Technique for the early detection of drug-resistant HBV DNA during antiviral therapy
AU - Yeon, Jong Eun
PY - 2008/6/1
Y1 - 2008/6/1
N2 - Early detection of antiviral resistant mutants is of clinical importance in patients receiving antiviral treatment. The ideal assay is sensitive, specific, accurate, reproducible and easy to perform, attains a high throughput and is able to detect mixed and novel mutations. Advantages and disadvantages of sequencing, line probe assay, DNA chip technology, peptide nucleic acid cramping, fluorescent biprobe hybridization and a new technique based on matrix-assisted laser desorption/ionization time-of-flight mass-spectrometric analysis will be discussed.
AB - Early detection of antiviral resistant mutants is of clinical importance in patients receiving antiviral treatment. The ideal assay is sensitive, specific, accurate, reproducible and easy to perform, attains a high throughput and is able to detect mixed and novel mutations. Advantages and disadvantages of sequencing, line probe assay, DNA chip technology, peptide nucleic acid cramping, fluorescent biprobe hybridization and a new technique based on matrix-assisted laser desorption/ionization time-of-flight mass-spectrometric analysis will be discussed.
KW - Antiviral drug resistance
KW - HBV
KW - Laser desorption/ionization
KW - Mass spectrometry analysis
KW - Resistant mutants
UR - http://www.scopus.com/inward/record.url?scp=44949159715&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=44949159715&partnerID=8YFLogxK
U2 - 10.1159/000122593
DO - 10.1159/000122593
M3 - Article
C2 - 18544942
AN - SCOPUS:44949159715
VL - 51
SP - 7
EP - 10
JO - Intervirology
JF - Intervirology
SN - 0300-5526
IS - SUPPL. 1
ER -