Technique for the early detection of drug-resistant HBV DNA during antiviral therapy

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Early detection of antiviral resistant mutants is of clinical importance in patients receiving antiviral treatment. The ideal assay is sensitive, specific, accurate, reproducible and easy to perform, attains a high throughput and is able to detect mixed and novel mutations. Advantages and disadvantages of sequencing, line probe assay, DNA chip technology, peptide nucleic acid cramping, fluorescent biprobe hybridization and a new technique based on matrix-assisted laser desorption/ionization time-of-flight mass-spectrometric analysis will be discussed.

Original languageEnglish
Pages (from-to)7-10
Number of pages4
Issue numberSUPPL. 1
Publication statusPublished - 2008 Jun 1



  • Antiviral drug resistance
  • HBV
  • Laser desorption/ionization
  • Mass spectrometry analysis
  • Resistant mutants

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

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