Abstract
Early detection of antiviral resistant mutants is of clinical importance in patients receiving antiviral treatment. The ideal assay is sensitive, specific, accurate, reproducible and easy to perform, attains a high throughput and is able to detect mixed and novel mutations. Advantages and disadvantages of sequencing, line probe assay, DNA chip technology, peptide nucleic acid cramping, fluorescent biprobe hybridization and a new technique based on matrix-assisted laser desorption/ionization time-of-flight mass-spectrometric analysis will be discussed.
Original language | English |
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Pages (from-to) | 7-10 |
Number of pages | 4 |
Journal | Intervirology |
Volume | 51 |
Issue number | SUPPL. 1 |
DOIs | |
Publication status | Published - 2008 Jun |
Externally published | Yes |
Keywords
- Antiviral drug resistance
- HBV
- Laser desorption/ionization
- Mass spectrometry analysis
- Resistant mutants
ASJC Scopus subject areas
- Virology
- Infectious Diseases