Technological progress in generation of induced pluripotent stem cells for clinical applications

Seung Ick Oh, Chang Kyu Lee, Kyung Jin Cho, Kyung Ok Lee, Ssang Goo Cho, Sunghoi Hong

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) is achieved by viral-mediated transduction of defined transcription factors. Generation of iPSCs is of great medical interest as they have the potential to be a source of patient-specific cells. For the eventual goal of clinical application, it is necessary to overcome the limitations of low reprogramming efficiency and chromosomal abnormalities due to viral DNA integration. In this paper, we summarize the current state of reprogramming technology for generation of iPSCs and also discuss potential approaches to the development of safe iPSCs for personalized cell-based replacement therapy.

Original languageEnglish
Article number417809
JournalThe Scientific World Journal
Volume2012
DOIs
Publication statusPublished - 2012 Apr 16

Fingerprint

Induced Pluripotent Stem Cells
Stem cells
stem
Virus Integration
Viral DNA
abnormality
Chromosome Aberrations
Transcription Factors
replacement
Technology
DNA
Therapeutics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Medicine(all)

Cite this

Technological progress in generation of induced pluripotent stem cells for clinical applications. / Oh, Seung Ick; Lee, Chang Kyu; Cho, Kyung Jin; Lee, Kyung Ok; Cho, Ssang Goo; Hong, Sunghoi.

In: The Scientific World Journal, Vol. 2012, 417809, 16.04.2012.

Research output: Contribution to journalArticle

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