Abstract
Vascular endothelial growth factor (VEGF)-loaded core/shell nanoparticles were prepared and their gelation behavior in response to temperature was characterized for the regeneration of ischemic heart. The core is composed of lecithin containing VEGF and the shell is composed of Pluronic F-127 (poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer). When Capryol 90 (propylene glycol monocaprylate) was added to an aqueous solution of the core/shell nanoparticles, a temperature-induced gel composed of core/shell nanoparticles was observed to form at body temperature. This phenomenon was utilized for the stable localization of core/shell nanoparticles at the ischemic area. For an in vivo assessment, VEGF-loaded core/shell nanoparticles with and without inducement of the gel formation were applied to a subacute myocardial infarction model in rats and functional analysis of the heart was monitored by means of a PV catheter four weeks later. The results showed that the VEGF-loaded core/shell nanoparticles and their gel improved the heart functions, particularly with regard to the ejection fraction and cardiac output.
| Original language | English |
|---|---|
| Pages (from-to) | 207-211 |
| Number of pages | 5 |
| Journal | Journal of Controlled Release |
| Volume | 146 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2010 Sep 1 |
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Keywords
- Core/shell nanoparticles
- Pluronic F-127
- Regeneration of ischemic heart
- Temperature-induced gel formation
- Vascular endothelial growth factor
ASJC Scopus subject areas
- Pharmaceutical Science
Cite this
Temperature-induced gel formation of core/shell nanoparticles for the regeneration of ischemic heart. / Oh, Keun Sang; Song, Ji Young; Yoon, So Jeong; Park, Yongdoo; Kim, Dongmin; Yuk, Soon Hong.
In: Journal of Controlled Release, Vol. 146, No. 2, 01.09.2010, p. 207-211.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Temperature-induced gel formation of core/shell nanoparticles for the regeneration of ischemic heart
AU - Oh, Keun Sang
AU - Song, Ji Young
AU - Yoon, So Jeong
AU - Park, Yongdoo
AU - Kim, Dongmin
AU - Yuk, Soon Hong
PY - 2010/9/1
Y1 - 2010/9/1
N2 - Vascular endothelial growth factor (VEGF)-loaded core/shell nanoparticles were prepared and their gelation behavior in response to temperature was characterized for the regeneration of ischemic heart. The core is composed of lecithin containing VEGF and the shell is composed of Pluronic F-127 (poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer). When Capryol 90 (propylene glycol monocaprylate) was added to an aqueous solution of the core/shell nanoparticles, a temperature-induced gel composed of core/shell nanoparticles was observed to form at body temperature. This phenomenon was utilized for the stable localization of core/shell nanoparticles at the ischemic area. For an in vivo assessment, VEGF-loaded core/shell nanoparticles with and without inducement of the gel formation were applied to a subacute myocardial infarction model in rats and functional analysis of the heart was monitored by means of a PV catheter four weeks later. The results showed that the VEGF-loaded core/shell nanoparticles and their gel improved the heart functions, particularly with regard to the ejection fraction and cardiac output.
AB - Vascular endothelial growth factor (VEGF)-loaded core/shell nanoparticles were prepared and their gelation behavior in response to temperature was characterized for the regeneration of ischemic heart. The core is composed of lecithin containing VEGF and the shell is composed of Pluronic F-127 (poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer). When Capryol 90 (propylene glycol monocaprylate) was added to an aqueous solution of the core/shell nanoparticles, a temperature-induced gel composed of core/shell nanoparticles was observed to form at body temperature. This phenomenon was utilized for the stable localization of core/shell nanoparticles at the ischemic area. For an in vivo assessment, VEGF-loaded core/shell nanoparticles with and without inducement of the gel formation were applied to a subacute myocardial infarction model in rats and functional analysis of the heart was monitored by means of a PV catheter four weeks later. The results showed that the VEGF-loaded core/shell nanoparticles and their gel improved the heart functions, particularly with regard to the ejection fraction and cardiac output.
KW - Core/shell nanoparticles
KW - Pluronic F-127
KW - Regeneration of ischemic heart
KW - Temperature-induced gel formation
KW - Vascular endothelial growth factor
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UR - http://www.scopus.com/inward/citedby.url?scp=77955428420&partnerID=8YFLogxK
U2 - 10.1016/j.jconrel.2010.04.014
DO - 10.1016/j.jconrel.2010.04.014
M3 - Article
C2 - 20417673
AN - SCOPUS:77955428420
VL - 146
SP - 207
EP - 211
JO - Journal of Controlled Release
JF - Journal of Controlled Release
SN - 0168-3659
IS - 2
ER -