Test-retest stability of cardiovascular and subjective responses to intravenous cocaine in humans

C. Nagoshi, K. M. Kumor, Carles Muntaner

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Sixteen male i.v. cocaine users were measured on their cardiovascular and subjective responses to placebo followed on a separate day by 40mg i.v. cocaine injections. They were retested within 2 weeks, again receiving placebo and 40mg i.v. cocaine injections in a random order on separate days. Significant increases in baseline (pre-injection) heart rates during the later sessions were interpreted as possibly reflecting conditioning effects. There were no significant differences in post-injection increases in cardiovascular or subjective responses between the initial and later 40mg conditions, which might have been indicative of tolerance or sensitization development. Test-retest correlations, indicative of response stability, were moderate to high for any particular timepoint for blood pressure, heart rate, and subjective responses, but pre- vs. post-injection change scores were stable across testings on these measures only under placebo. With the possible exception of some subjective responses, there was little evidence of test-retest stability in responses (change scores) to the 40mg cocaine injection.

Original languageEnglish
Pages (from-to)591-599
Number of pages9
JournalBritish Journal of Addiction
Volume87
Issue number4
Publication statusPublished - 1992 Jan 1
Externally publishedYes

Fingerprint

Cocaine
Injections
Placebos
Heart Rate
Blood Pressure

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Test-retest stability of cardiovascular and subjective responses to intravenous cocaine in humans. / Nagoshi, C.; Kumor, K. M.; Muntaner, Carles.

In: British Journal of Addiction, Vol. 87, No. 4, 01.01.1992, p. 591-599.

Research output: Contribution to journalArticle

Nagoshi, C. ; Kumor, K. M. ; Muntaner, Carles. / Test-retest stability of cardiovascular and subjective responses to intravenous cocaine in humans. In: British Journal of Addiction. 1992 ; Vol. 87, No. 4. pp. 591-599.
@article{642499de16fe4b4ab9c1c21ef613e5e9,
title = "Test-retest stability of cardiovascular and subjective responses to intravenous cocaine in humans",
abstract = "Sixteen male i.v. cocaine users were measured on their cardiovascular and subjective responses to placebo followed on a separate day by 40mg i.v. cocaine injections. They were retested within 2 weeks, again receiving placebo and 40mg i.v. cocaine injections in a random order on separate days. Significant increases in baseline (pre-injection) heart rates during the later sessions were interpreted as possibly reflecting conditioning effects. There were no significant differences in post-injection increases in cardiovascular or subjective responses between the initial and later 40mg conditions, which might have been indicative of tolerance or sensitization development. Test-retest correlations, indicative of response stability, were moderate to high for any particular timepoint for blood pressure, heart rate, and subjective responses, but pre- vs. post-injection change scores were stable across testings on these measures only under placebo. With the possible exception of some subjective responses, there was little evidence of test-retest stability in responses (change scores) to the 40mg cocaine injection.",
author = "C. Nagoshi and Kumor, {K. M.} and Carles Muntaner",
year = "1992",
month = "1",
day = "1",
language = "English",
volume = "87",
pages = "591--599",
journal = "Addiction",
issn = "0965-2140",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Test-retest stability of cardiovascular and subjective responses to intravenous cocaine in humans

AU - Nagoshi, C.

AU - Kumor, K. M.

AU - Muntaner, Carles

PY - 1992/1/1

Y1 - 1992/1/1

N2 - Sixteen male i.v. cocaine users were measured on their cardiovascular and subjective responses to placebo followed on a separate day by 40mg i.v. cocaine injections. They were retested within 2 weeks, again receiving placebo and 40mg i.v. cocaine injections in a random order on separate days. Significant increases in baseline (pre-injection) heart rates during the later sessions were interpreted as possibly reflecting conditioning effects. There were no significant differences in post-injection increases in cardiovascular or subjective responses between the initial and later 40mg conditions, which might have been indicative of tolerance or sensitization development. Test-retest correlations, indicative of response stability, were moderate to high for any particular timepoint for blood pressure, heart rate, and subjective responses, but pre- vs. post-injection change scores were stable across testings on these measures only under placebo. With the possible exception of some subjective responses, there was little evidence of test-retest stability in responses (change scores) to the 40mg cocaine injection.

AB - Sixteen male i.v. cocaine users were measured on their cardiovascular and subjective responses to placebo followed on a separate day by 40mg i.v. cocaine injections. They were retested within 2 weeks, again receiving placebo and 40mg i.v. cocaine injections in a random order on separate days. Significant increases in baseline (pre-injection) heart rates during the later sessions were interpreted as possibly reflecting conditioning effects. There were no significant differences in post-injection increases in cardiovascular or subjective responses between the initial and later 40mg conditions, which might have been indicative of tolerance or sensitization development. Test-retest correlations, indicative of response stability, were moderate to high for any particular timepoint for blood pressure, heart rate, and subjective responses, but pre- vs. post-injection change scores were stable across testings on these measures only under placebo. With the possible exception of some subjective responses, there was little evidence of test-retest stability in responses (change scores) to the 40mg cocaine injection.

UR - http://www.scopus.com/inward/record.url?scp=0026546306&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026546306&partnerID=8YFLogxK

M3 - Article

VL - 87

SP - 591

EP - 599

JO - Addiction

JF - Addiction

SN - 0965-2140

IS - 4

ER -