TGF-β-treated antigen presenting cells suppress collagen-induced arthritis through the promotion of Th2 responses

Sundo Jung, Yoon Kyung Park, Hyunji Lee, Jung Hoon Shin, Gap Ryol Lee, Se-Ho Park

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Collagen-induced arthritis (CIA) is mediated by self-re-active CD4+ T cells that produce inflammatory cytokines. TGF-β2-treated tolerogenic antigen-presenting cells (Tol-APCs) are known to induce tolerance in various autoimmune diseases. In this study, we investigated whether collagen-specific Tol-APCs could induce suppression of CIA. We observed that Tol-APCs could suppress the development and se-verity of CIA and delay the onset of CIA. Treatment of Tol-APCs reduced the number of IFN-γ- and IL-17-producing CD4+ T cells and increased IL-4- and IL-5-producing CD4+ T cells upon collagen antigen stimulation in vitro. The suppression of CIA conferred by Tol-APCs correlated with their ability to selectively induce IL-10 production. We also observed that treatment of Tol-APCs inhibited not only cellular immune responses but also humoral immune responses in the process of CIA. Our results suggest that in vitro-generated Tol-APCs have potential therapeutic value for the treatment of rheumatoid arthritis as well as other autoimmune diseases.

Original languageEnglish
Pages (from-to)187-194
Number of pages8
JournalExperimental and Molecular Medicine
Volume42
Issue number3
DOIs
Publication statusPublished - 2010 Mar 31

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Keywords

  • Antigen-presenting cells
  • Arthritis
  • Autoimmune diseases
  • Experimental
  • Immune tolerance
  • Th1 cells
  • Th2 cells

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Molecular Medicine
  • Clinical Biochemistry

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