TGFBIp/βig-h3 protein: A versatile matrix molecule induced by TGF-β

Narendra Thapa; Byung Heon Lee; In San Kim

doi:10.1016/j.biocel.2007.06.004

TGFBIp/βig-h3 protein: A versatile matrix molecule induced by TGF-β

Narendra Thapa, Byung Heon Lee, In San Kim

Research output: Contribution to journal › Review article › peer-review

146 Citations (Scopus)

Abstract

TGFBIp/βig-h3 protein is an extracellular matrix molecule initially cloned from human adenocarcinoma cells treated with TGF-β. Its precise function remains obscure but a number of studies have demonstrated it to be an intriguingly versatile molecule role in a wide range of physiological and pathological conditions. To date, the most extensively studied and reported action of TGFBIp/βig-h3 protein is in corneal dystrophy and several excellent reviews are available on this. Work from various laboratories on this molecule has compiled a tremendous amount of information over the past decade and a half. Here we review the current understanding on TGFBIp/βig-h3 protein and its functions in morphogenesis, extracellular matrix interactions, adhesion/migration, corneal dystrophy, tumorigenesis, angiogenesis, nephropathies, osteogenesis, wound healing and inflammation.

Original language	English
Pages (from-to)	2183-2194
Number of pages	12
Journal	International Journal of Biochemistry and Cell Biology
Volume	39
Issue number	12
DOIs	https://doi.org/10.1016/j.biocel.2007.06.004
Publication status	Published - 2007
Externally published	Yes

Keywords

Angiogenesis
Cell adhesion
FAS1 domain
Inflammation
Integrin
Nephropathy
Osteogenesis
TGFBI
Tumorigenesis
Wound healing
βig-h3

ASJC Scopus subject areas

Biochemistry
Cell Biology

Access to Document

10.1016/j.biocel.2007.06.004

Cite this

@article{309d9fbe0d4443428cbe93906b62081e,

title = "TGFBIp/βig-h3 protein: A versatile matrix molecule induced by TGF-β",

abstract = "TGFBIp/βig-h3 protein is an extracellular matrix molecule initially cloned from human adenocarcinoma cells treated with TGF-β. Its precise function remains obscure but a number of studies have demonstrated it to be an intriguingly versatile molecule role in a wide range of physiological and pathological conditions. To date, the most extensively studied and reported action of TGFBIp/βig-h3 protein is in corneal dystrophy and several excellent reviews are available on this. Work from various laboratories on this molecule has compiled a tremendous amount of information over the past decade and a half. Here we review the current understanding on TGFBIp/βig-h3 protein and its functions in morphogenesis, extracellular matrix interactions, adhesion/migration, corneal dystrophy, tumorigenesis, angiogenesis, nephropathies, osteogenesis, wound healing and inflammation.",

keywords = "Angiogenesis, Cell adhesion, FAS1 domain, Inflammation, Integrin, Nephropathy, Osteogenesis, TGFBI, Tumorigenesis, Wound healing, βig-h3",

author = "Narendra Thapa and Lee, {Byung Heon} and Kim, {In San}",

note = "Funding Information: This work was supported by Brain Korea 21 programs and Regional Research Center. The authors apologize for omission of some references due to space limitations. Copyright: Copyright 2009 Elsevier B.V., All rights reserved.",

year = "2007",

doi = "10.1016/j.biocel.2007.06.004",

language = "English",

volume = "39",

pages = "2183--2194",

journal = "International Journal of Biochemistry and Cell Biology",

issn = "1357-2725",

publisher = "Elsevier Limited",

number = "12",

}

TY - JOUR

T1 - TGFBIp/βig-h3 protein

T2 - A versatile matrix molecule induced by TGF-β

AU - Thapa, Narendra

AU - Lee, Byung Heon

AU - Kim, In San

N1 - Funding Information: This work was supported by Brain Korea 21 programs and Regional Research Center. The authors apologize for omission of some references due to space limitations. Copyright: Copyright 2009 Elsevier B.V., All rights reserved.

PY - 2007

Y1 - 2007

N2 - TGFBIp/βig-h3 protein is an extracellular matrix molecule initially cloned from human adenocarcinoma cells treated with TGF-β. Its precise function remains obscure but a number of studies have demonstrated it to be an intriguingly versatile molecule role in a wide range of physiological and pathological conditions. To date, the most extensively studied and reported action of TGFBIp/βig-h3 protein is in corneal dystrophy and several excellent reviews are available on this. Work from various laboratories on this molecule has compiled a tremendous amount of information over the past decade and a half. Here we review the current understanding on TGFBIp/βig-h3 protein and its functions in morphogenesis, extracellular matrix interactions, adhesion/migration, corneal dystrophy, tumorigenesis, angiogenesis, nephropathies, osteogenesis, wound healing and inflammation.

AB - TGFBIp/βig-h3 protein is an extracellular matrix molecule initially cloned from human adenocarcinoma cells treated with TGF-β. Its precise function remains obscure but a number of studies have demonstrated it to be an intriguingly versatile molecule role in a wide range of physiological and pathological conditions. To date, the most extensively studied and reported action of TGFBIp/βig-h3 protein is in corneal dystrophy and several excellent reviews are available on this. Work from various laboratories on this molecule has compiled a tremendous amount of information over the past decade and a half. Here we review the current understanding on TGFBIp/βig-h3 protein and its functions in morphogenesis, extracellular matrix interactions, adhesion/migration, corneal dystrophy, tumorigenesis, angiogenesis, nephropathies, osteogenesis, wound healing and inflammation.

KW - Angiogenesis

KW - Cell adhesion

KW - FAS1 domain

KW - Inflammation

KW - Integrin

KW - Nephropathy

KW - Osteogenesis

KW - TGFBI

KW - Tumorigenesis

KW - Wound healing

KW - βig-h3

UR - http://www.scopus.com/inward/record.url?scp=34748877706&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34748877706&partnerID=8YFLogxK

U2 - 10.1016/j.biocel.2007.06.004

DO - 10.1016/j.biocel.2007.06.004

M3 - Review article

C2 - 17659994

AN - SCOPUS:34748877706

SN - 1357-2725

VL - 39

SP - 2183

EP - 2194

JO - International Journal of Biochemistry and Cell Biology

JF - International Journal of Biochemistry and Cell Biology

IS - 12

ER -

TGFBIp/βig-h3 protein: A versatile matrix molecule induced by TGF-β

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this