TGFBIp/βig-h3 protein: A versatile matrix molecule induced by TGF-β

Narendra Thapa, Byung Heon Lee, In San Kim

Research output: Contribution to journalReview article

117 Citations (Scopus)

Abstract

TGFBIp/βig-h3 protein is an extracellular matrix molecule initially cloned from human adenocarcinoma cells treated with TGF-β. Its precise function remains obscure but a number of studies have demonstrated it to be an intriguingly versatile molecule role in a wide range of physiological and pathological conditions. To date, the most extensively studied and reported action of TGFBIp/βig-h3 protein is in corneal dystrophy and several excellent reviews are available on this. Work from various laboratories on this molecule has compiled a tremendous amount of information over the past decade and a half. Here we review the current understanding on TGFBIp/βig-h3 protein and its functions in morphogenesis, extracellular matrix interactions, adhesion/migration, corneal dystrophy, tumorigenesis, angiogenesis, nephropathies, osteogenesis, wound healing and inflammation.

Original languageEnglish
Pages (from-to)2183-2194
Number of pages12
JournalInternational Journal of Biochemistry and Cell Biology
Volume39
Issue number12
DOIs
Publication statusPublished - 2007
Externally publishedYes

Keywords

  • Angiogenesis
  • Cell adhesion
  • FAS1 domain
  • Inflammation
  • Integrin
  • Nephropathy
  • Osteogenesis
  • TGFBI
  • Tumorigenesis
  • Wound healing
  • βig-h3

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

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