Abstract
Several studies have shown that there is an imbalance between T helper 1 (Th1) cytokines and T helper 2 (Th2) cytokines in patients with schizophrenia. The T helper 3 (Th3) cytokine, transforming growth factor beta-1 (TGF-β1), has been shown to suppress the production of Th1 cytokines. Therefore it is hypothesized that it may play a role in schizophrenia by suppressing overactive Th1 system. We recruited 88 schizophrenic patients and 88 matched controls. The basal plasma concentrations of IFN-γ (Th1), IL-4 (Th2) and TGF-β1 (Th3) were studied at the time the patients were admitted to the hospital and following 8 weeks of treatment with antipsychotics. The detection rate of plasma IFN-γ and basal plasma TGF-β1 level were significantly higher in schizophrenic patients than in controls whereas detection rate of plasma IL-4 was lower in patients. The ratio of Th1/Th2 cytokines (IFN-γ/IL-4) was higher in schizophrenic patients. Following the neuroleptic treatment, the IFNγ and TGF-β1 levels returned to control values, and IL-4 concentration rose above the control value. Schizophrenic patients showed higher Th1/Th2 ratio which is attenuated by effective neuroleptic treatment. It is possible that TGF-β1 plays a role in reducing the activity of Th1 cytokine.
| Original language | English |
|---|---|
| Pages (from-to) | 1129-1134 |
| Number of pages | 6 |
| Journal | Progress in Neuro-Psychopharmacology and Biological Psychiatry |
| Volume | 28 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2004 Nov 1 |
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Keywords
- Antipsychotic
- Cytokine
- Interferon
- Interleukin
- Schizophrenia
- TGF
ASJC Scopus subject areas
- Biological Psychiatry
- Pharmacology
Cite this
Th1, Th2 and Th3 cytokine alteration in schizophrenia. / Kim, Yong Ku; Myint, Aye Mu; Lee, Bun Hee; Han, Changsu; Lee, Heon-Jeong; Kim, Dae Jin; Leonard, Brian E.
In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 28, No. 7, 01.11.2004, p. 1129-1134.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Th1, Th2 and Th3 cytokine alteration in schizophrenia
AU - Kim, Yong Ku
AU - Myint, Aye Mu
AU - Lee, Bun Hee
AU - Han, Changsu
AU - Lee, Heon-Jeong
AU - Kim, Dae Jin
AU - Leonard, Brian E.
PY - 2004/11/1
Y1 - 2004/11/1
N2 - Several studies have shown that there is an imbalance between T helper 1 (Th1) cytokines and T helper 2 (Th2) cytokines in patients with schizophrenia. The T helper 3 (Th3) cytokine, transforming growth factor beta-1 (TGF-β1), has been shown to suppress the production of Th1 cytokines. Therefore it is hypothesized that it may play a role in schizophrenia by suppressing overactive Th1 system. We recruited 88 schizophrenic patients and 88 matched controls. The basal plasma concentrations of IFN-γ (Th1), IL-4 (Th2) and TGF-β1 (Th3) were studied at the time the patients were admitted to the hospital and following 8 weeks of treatment with antipsychotics. The detection rate of plasma IFN-γ and basal plasma TGF-β1 level were significantly higher in schizophrenic patients than in controls whereas detection rate of plasma IL-4 was lower in patients. The ratio of Th1/Th2 cytokines (IFN-γ/IL-4) was higher in schizophrenic patients. Following the neuroleptic treatment, the IFNγ and TGF-β1 levels returned to control values, and IL-4 concentration rose above the control value. Schizophrenic patients showed higher Th1/Th2 ratio which is attenuated by effective neuroleptic treatment. It is possible that TGF-β1 plays a role in reducing the activity of Th1 cytokine.
AB - Several studies have shown that there is an imbalance between T helper 1 (Th1) cytokines and T helper 2 (Th2) cytokines in patients with schizophrenia. The T helper 3 (Th3) cytokine, transforming growth factor beta-1 (TGF-β1), has been shown to suppress the production of Th1 cytokines. Therefore it is hypothesized that it may play a role in schizophrenia by suppressing overactive Th1 system. We recruited 88 schizophrenic patients and 88 matched controls. The basal plasma concentrations of IFN-γ (Th1), IL-4 (Th2) and TGF-β1 (Th3) were studied at the time the patients were admitted to the hospital and following 8 weeks of treatment with antipsychotics. The detection rate of plasma IFN-γ and basal plasma TGF-β1 level were significantly higher in schizophrenic patients than in controls whereas detection rate of plasma IL-4 was lower in patients. The ratio of Th1/Th2 cytokines (IFN-γ/IL-4) was higher in schizophrenic patients. Following the neuroleptic treatment, the IFNγ and TGF-β1 levels returned to control values, and IL-4 concentration rose above the control value. Schizophrenic patients showed higher Th1/Th2 ratio which is attenuated by effective neuroleptic treatment. It is possible that TGF-β1 plays a role in reducing the activity of Th1 cytokine.
KW - Antipsychotic
KW - Cytokine
KW - Interferon
KW - Interleukin
KW - Schizophrenia
KW - TGF
UR - http://www.scopus.com/inward/record.url?scp=10944266569&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=10944266569&partnerID=8YFLogxK
U2 - 10.1016/j.pnpbp.2004.05.047
DO - 10.1016/j.pnpbp.2004.05.047
M3 - Article
C2 - 15610925
AN - SCOPUS:10944266569
VL - 28
SP - 1129
EP - 1134
JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry
JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry
SN - 0278-5846
IS - 7
ER -