Th1, Th2 and Th3 cytokine alteration in schizophrenia

Yong Ku Kim; Aye Mu Myint; Bun Hee Lee; Chang Su Han; Heon Jeong Lee; Dae Jin Kim; Brian E. Leonard

doi:10.1016/j.pnpbp.2004.05.047

Th1, Th2 and Th3 cytokine alteration in schizophrenia

Yong Ku Kim, Aye Mu Myint, Bun Hee Lee, Chang Su Han, Heon Jeong Lee, Dae Jin Kim, Brian E. Leonard

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

171 Citations (Scopus)

Abstract

Several studies have shown that there is an imbalance between T helper 1 (Th1) cytokines and T helper 2 (Th2) cytokines in patients with schizophrenia. The T helper 3 (Th3) cytokine, transforming growth factor beta-1 (TGF-β1), has been shown to suppress the production of Th1 cytokines. Therefore it is hypothesized that it may play a role in schizophrenia by suppressing overactive Th1 system. We recruited 88 schizophrenic patients and 88 matched controls. The basal plasma concentrations of IFN-γ (Th1), IL-4 (Th2) and TGF-β1 (Th3) were studied at the time the patients were admitted to the hospital and following 8 weeks of treatment with antipsychotics. The detection rate of plasma IFN-γ and basal plasma TGF-β1 level were significantly higher in schizophrenic patients than in controls whereas detection rate of plasma IL-4 was lower in patients. The ratio of Th1/Th2 cytokines (IFN-γ/IL-4) was higher in schizophrenic patients. Following the neuroleptic treatment, the IFNγ and TGF-β1 levels returned to control values, and IL-4 concentration rose above the control value. Schizophrenic patients showed higher Th1/Th2 ratio which is attenuated by effective neuroleptic treatment. It is possible that TGF-β1 plays a role in reducing the activity of Th1 cytokine.

Original language	English
Pages (from-to)	1129-1134
Number of pages	6
Journal	Progress in Neuro-Psychopharmacology and Biological Psychiatry
Volume	28
Issue number	7
DOIs	https://doi.org/10.1016/j.pnpbp.2004.05.047
Publication status	Published - 2004 Nov

Keywords

Antipsychotic
Cytokine
Interferon
Interleukin
Schizophrenia
TGF

ASJC Scopus subject areas

Pharmacology
Biological Psychiatry

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10.1016/j.pnpbp.2004.05.047

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title = "Th1, Th2 and Th3 cytokine alteration in schizophrenia",

abstract = "Several studies have shown that there is an imbalance between T helper 1 (Th1) cytokines and T helper 2 (Th2) cytokines in patients with schizophrenia. The T helper 3 (Th3) cytokine, transforming growth factor beta-1 (TGF-β1), has been shown to suppress the production of Th1 cytokines. Therefore it is hypothesized that it may play a role in schizophrenia by suppressing overactive Th1 system. We recruited 88 schizophrenic patients and 88 matched controls. The basal plasma concentrations of IFN-γ (Th1), IL-4 (Th2) and TGF-β1 (Th3) were studied at the time the patients were admitted to the hospital and following 8 weeks of treatment with antipsychotics. The detection rate of plasma IFN-γ and basal plasma TGF-β1 level were significantly higher in schizophrenic patients than in controls whereas detection rate of plasma IL-4 was lower in patients. The ratio of Th1/Th2 cytokines (IFN-γ/IL-4) was higher in schizophrenic patients. Following the neuroleptic treatment, the IFNγ and TGF-β1 levels returned to control values, and IL-4 concentration rose above the control value. Schizophrenic patients showed higher Th1/Th2 ratio which is attenuated by effective neuroleptic treatment. It is possible that TGF-β1 plays a role in reducing the activity of Th1 cytokine.",

keywords = "Antipsychotic, Cytokine, Interferon, Interleukin, Schizophrenia, TGF",

author = "Kim, {Yong Ku} and Myint, {Aye Mu} and Lee, {Bun Hee} and Han, {Chang Su} and Lee, {Heon Jeong} and Kim, {Dae Jin} and Leonard, {Brian E.}",

note = "Funding Information: Dr. Yong-Ku Kim is supported by the Brain Korea 21 Project of the Ministry of Education and Human Resources Development, Republic of Korea.",

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AU - Kim, Yong Ku

AU - Myint, Aye Mu

AU - Lee, Bun Hee

AU - Han, Chang Su

AU - Lee, Heon Jeong

AU - Kim, Dae Jin

AU - Leonard, Brian E.

N1 - Funding Information: Dr. Yong-Ku Kim is supported by the Brain Korea 21 Project of the Ministry of Education and Human Resources Development, Republic of Korea.

PY - 2004/11

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N2 - Several studies have shown that there is an imbalance between T helper 1 (Th1) cytokines and T helper 2 (Th2) cytokines in patients with schizophrenia. The T helper 3 (Th3) cytokine, transforming growth factor beta-1 (TGF-β1), has been shown to suppress the production of Th1 cytokines. Therefore it is hypothesized that it may play a role in schizophrenia by suppressing overactive Th1 system. We recruited 88 schizophrenic patients and 88 matched controls. The basal plasma concentrations of IFN-γ (Th1), IL-4 (Th2) and TGF-β1 (Th3) were studied at the time the patients were admitted to the hospital and following 8 weeks of treatment with antipsychotics. The detection rate of plasma IFN-γ and basal plasma TGF-β1 level were significantly higher in schizophrenic patients than in controls whereas detection rate of plasma IL-4 was lower in patients. The ratio of Th1/Th2 cytokines (IFN-γ/IL-4) was higher in schizophrenic patients. Following the neuroleptic treatment, the IFNγ and TGF-β1 levels returned to control values, and IL-4 concentration rose above the control value. Schizophrenic patients showed higher Th1/Th2 ratio which is attenuated by effective neuroleptic treatment. It is possible that TGF-β1 plays a role in reducing the activity of Th1 cytokine.

AB - Several studies have shown that there is an imbalance between T helper 1 (Th1) cytokines and T helper 2 (Th2) cytokines in patients with schizophrenia. The T helper 3 (Th3) cytokine, transforming growth factor beta-1 (TGF-β1), has been shown to suppress the production of Th1 cytokines. Therefore it is hypothesized that it may play a role in schizophrenia by suppressing overactive Th1 system. We recruited 88 schizophrenic patients and 88 matched controls. The basal plasma concentrations of IFN-γ (Th1), IL-4 (Th2) and TGF-β1 (Th3) were studied at the time the patients were admitted to the hospital and following 8 weeks of treatment with antipsychotics. The detection rate of plasma IFN-γ and basal plasma TGF-β1 level were significantly higher in schizophrenic patients than in controls whereas detection rate of plasma IL-4 was lower in patients. The ratio of Th1/Th2 cytokines (IFN-γ/IL-4) was higher in schizophrenic patients. Following the neuroleptic treatment, the IFNγ and TGF-β1 levels returned to control values, and IL-4 concentration rose above the control value. Schizophrenic patients showed higher Th1/Th2 ratio which is attenuated by effective neuroleptic treatment. It is possible that TGF-β1 plays a role in reducing the activity of Th1 cytokine.

KW - Antipsychotic

KW - Cytokine

KW - Interferon

KW - Interleukin

KW - Schizophrenia

KW - TGF

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ER -

Th1, Th2 and Th3 cytokine alteration in schizophrenia

Abstract

Keywords

ASJC Scopus subject areas

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