Th1, Th2 and Th3 cytokine alteration in schizophrenia

Yong Ku Kim, Aye Mu Myint, Bun Hee Lee, Changsu Han, Heon-Jeong Lee, Dae Jin Kim, Brian E. Leonard

Research output: Contribution to journalArticle

145 Citations (Scopus)

Abstract

Several studies have shown that there is an imbalance between T helper 1 (Th1) cytokines and T helper 2 (Th2) cytokines in patients with schizophrenia. The T helper 3 (Th3) cytokine, transforming growth factor beta-1 (TGF-β1), has been shown to suppress the production of Th1 cytokines. Therefore it is hypothesized that it may play a role in schizophrenia by suppressing overactive Th1 system. We recruited 88 schizophrenic patients and 88 matched controls. The basal plasma concentrations of IFN-γ (Th1), IL-4 (Th2) and TGF-β1 (Th3) were studied at the time the patients were admitted to the hospital and following 8 weeks of treatment with antipsychotics. The detection rate of plasma IFN-γ and basal plasma TGF-β1 level were significantly higher in schizophrenic patients than in controls whereas detection rate of plasma IL-4 was lower in patients. The ratio of Th1/Th2 cytokines (IFN-γ/IL-4) was higher in schizophrenic patients. Following the neuroleptic treatment, the IFNγ and TGF-β1 levels returned to control values, and IL-4 concentration rose above the control value. Schizophrenic patients showed higher Th1/Th2 ratio which is attenuated by effective neuroleptic treatment. It is possible that TGF-β1 plays a role in reducing the activity of Th1 cytokine.

Original languageEnglish
Pages (from-to)1129-1134
Number of pages6
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume28
Issue number7
DOIs
Publication statusPublished - 2004 Nov 1

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Schizophrenia
Cytokines
Transforming Growth Factor beta
Interleukin-4
Antipsychotic Agents
Therapeutics

Keywords

  • Antipsychotic
  • Cytokine
  • Interferon
  • Interleukin
  • Schizophrenia
  • TGF

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology

Cite this

Th1, Th2 and Th3 cytokine alteration in schizophrenia. / Kim, Yong Ku; Myint, Aye Mu; Lee, Bun Hee; Han, Changsu; Lee, Heon-Jeong; Kim, Dae Jin; Leonard, Brian E.

In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 28, No. 7, 01.11.2004, p. 1129-1134.

Research output: Contribution to journalArticle

Kim, Yong Ku ; Myint, Aye Mu ; Lee, Bun Hee ; Han, Changsu ; Lee, Heon-Jeong ; Kim, Dae Jin ; Leonard, Brian E. / Th1, Th2 and Th3 cytokine alteration in schizophrenia. In: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2004 ; Vol. 28, No. 7. pp. 1129-1134.
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