The 24-Month Prognosis of Patients With Positive or Intermediate Results in the Intracoronary Ergonovine Provocation Test

Dong IL Shin, Sang Hong Baek, Sung Ho Her, Seung Hwan Han, Youngkeun Ahn, Keun Ho Park, Dong Soo Kim, Tae Hyun Yang, Dong Ju Choi, Jung Won Suh, Hyuck Moon Kwon, Byoung Kwon Lee, Hyeon Cheol Gwon, Seung-Woon Rha, Sang Ho Jo

Research output: Contribution to journalArticle

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Abstract

Abstract Objectives This study wasObjectives This study was an observational, multicenter registry to determine clinical characteristics and 24-month prognosis of patients who underwent intracoronary ergonovine provocation tests. Background The clinical characteristics and prognosis of patients who underwent the ergonovine provocation for vasospastic angina were not fully elucidated. Methods A total of 2,129 patients in the VA-KOREA (Vasospastic Angina in Korea) registry were classified into positive (n = 454), intermediate (n = 982), and negative (n = 693) groups by intracoronary ergonovine provocation tests. The 24-month incidences of cardiac death, new-onset arrhythmia, and acute coronary syndrome were determined (mean 26.7 ± 8.8 months). Results The number of smokers, frequency of angina before angiography, high-sensitivity C-reactive protein, and triglyceride were higher in the positive group than in other groups. The clinical characteristics of the intermediate and the negative groups were very similar. In the positive group, the incidences of diffuse, focal, and mixed spasm were 65.9%, 23.6%, and 10.6%. Coronary spasm was more frequently provoked on atherosclerotic segments. The 24-month incidences of cardiac death, arrhythmia, and acute coronary syndrome were low (0.9%, 1.6%, and 1.9%, respectively) in the positive group, and there was no cardiac death in the intermediate group (p = 0.02). In the positive group, frequent angina, current smoking, and multivessel spasm were independent predictors for adverse events. Conclusions The 24-month prognosis of the positive group in the intracoronary ergonovine provocation test was relatively worse than that of the intermediate group. More intensive clinical attention should be paid to vasospastic angina patients with high-risk factors including frequent angina before angiography, current smoking, and multivessel spasm.

Original languageEnglish
Article number2002
Pages (from-to)914-923
Number of pages10
JournalJACC: Cardiovascular Interventions
Volume8
Issue number7
DOIs
Publication statusPublished - 2015 Jun 1

Fingerprint

Ergonovine
Spasm
Acute Coronary Syndrome
Registries
Cardiac Arrhythmias
Incidence
Angiography
Smoking
Korea
C-Reactive Protein
Observational Studies
Triglycerides

Keywords

  • ergonovine
  • prognosis
  • vasospastic angina

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

The 24-Month Prognosis of Patients With Positive or Intermediate Results in the Intracoronary Ergonovine Provocation Test. / Shin, Dong IL; Baek, Sang Hong; Her, Sung Ho; Han, Seung Hwan; Ahn, Youngkeun; Park, Keun Ho; Kim, Dong Soo; Yang, Tae Hyun; Choi, Dong Ju; Suh, Jung Won; Kwon, Hyuck Moon; Lee, Byoung Kwon; Gwon, Hyeon Cheol; Rha, Seung-Woon; Jo, Sang Ho.

In: JACC: Cardiovascular Interventions, Vol. 8, No. 7, 2002, 01.06.2015, p. 914-923.

Research output: Contribution to journalArticle

Shin, DIL, Baek, SH, Her, SH, Han, SH, Ahn, Y, Park, KH, Kim, DS, Yang, TH, Choi, DJ, Suh, JW, Kwon, HM, Lee, BK, Gwon, HC, Rha, S-W & Jo, SH 2015, 'The 24-Month Prognosis of Patients With Positive or Intermediate Results in the Intracoronary Ergonovine Provocation Test', JACC: Cardiovascular Interventions, vol. 8, no. 7, 2002, pp. 914-923. https://doi.org/10.1016/j.jcin.2014.12.249
Shin, Dong IL ; Baek, Sang Hong ; Her, Sung Ho ; Han, Seung Hwan ; Ahn, Youngkeun ; Park, Keun Ho ; Kim, Dong Soo ; Yang, Tae Hyun ; Choi, Dong Ju ; Suh, Jung Won ; Kwon, Hyuck Moon ; Lee, Byoung Kwon ; Gwon, Hyeon Cheol ; Rha, Seung-Woon ; Jo, Sang Ho. / The 24-Month Prognosis of Patients With Positive or Intermediate Results in the Intracoronary Ergonovine Provocation Test. In: JACC: Cardiovascular Interventions. 2015 ; Vol. 8, No. 7. pp. 914-923.
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abstract = "Abstract Objectives This study wasObjectives This study was an observational, multicenter registry to determine clinical characteristics and 24-month prognosis of patients who underwent intracoronary ergonovine provocation tests. Background The clinical characteristics and prognosis of patients who underwent the ergonovine provocation for vasospastic angina were not fully elucidated. Methods A total of 2,129 patients in the VA-KOREA (Vasospastic Angina in Korea) registry were classified into positive (n = 454), intermediate (n = 982), and negative (n = 693) groups by intracoronary ergonovine provocation tests. The 24-month incidences of cardiac death, new-onset arrhythmia, and acute coronary syndrome were determined (mean 26.7 ± 8.8 months). Results The number of smokers, frequency of angina before angiography, high-sensitivity C-reactive protein, and triglyceride were higher in the positive group than in other groups. The clinical characteristics of the intermediate and the negative groups were very similar. In the positive group, the incidences of diffuse, focal, and mixed spasm were 65.9{\%}, 23.6{\%}, and 10.6{\%}. Coronary spasm was more frequently provoked on atherosclerotic segments. The 24-month incidences of cardiac death, arrhythmia, and acute coronary syndrome were low (0.9{\%}, 1.6{\%}, and 1.9{\%}, respectively) in the positive group, and there was no cardiac death in the intermediate group (p = 0.02). In the positive group, frequent angina, current smoking, and multivessel spasm were independent predictors for adverse events. Conclusions The 24-month prognosis of the positive group in the intracoronary ergonovine provocation test was relatively worse than that of the intermediate group. More intensive clinical attention should be paid to vasospastic angina patients with high-risk factors including frequent angina before angiography, current smoking, and multivessel spasm.",
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AU - Shin, Dong IL

AU - Baek, Sang Hong

AU - Her, Sung Ho

AU - Han, Seung Hwan

AU - Ahn, Youngkeun

AU - Park, Keun Ho

AU - Kim, Dong Soo

AU - Yang, Tae Hyun

AU - Choi, Dong Ju

AU - Suh, Jung Won

AU - Kwon, Hyuck Moon

AU - Lee, Byoung Kwon

AU - Gwon, Hyeon Cheol

AU - Rha, Seung-Woon

AU - Jo, Sang Ho

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N2 - Abstract Objectives This study wasObjectives This study was an observational, multicenter registry to determine clinical characteristics and 24-month prognosis of patients who underwent intracoronary ergonovine provocation tests. Background The clinical characteristics and prognosis of patients who underwent the ergonovine provocation for vasospastic angina were not fully elucidated. Methods A total of 2,129 patients in the VA-KOREA (Vasospastic Angina in Korea) registry were classified into positive (n = 454), intermediate (n = 982), and negative (n = 693) groups by intracoronary ergonovine provocation tests. The 24-month incidences of cardiac death, new-onset arrhythmia, and acute coronary syndrome were determined (mean 26.7 ± 8.8 months). Results The number of smokers, frequency of angina before angiography, high-sensitivity C-reactive protein, and triglyceride were higher in the positive group than in other groups. The clinical characteristics of the intermediate and the negative groups were very similar. In the positive group, the incidences of diffuse, focal, and mixed spasm were 65.9%, 23.6%, and 10.6%. Coronary spasm was more frequently provoked on atherosclerotic segments. The 24-month incidences of cardiac death, arrhythmia, and acute coronary syndrome were low (0.9%, 1.6%, and 1.9%, respectively) in the positive group, and there was no cardiac death in the intermediate group (p = 0.02). In the positive group, frequent angina, current smoking, and multivessel spasm were independent predictors for adverse events. Conclusions The 24-month prognosis of the positive group in the intracoronary ergonovine provocation test was relatively worse than that of the intermediate group. More intensive clinical attention should be paid to vasospastic angina patients with high-risk factors including frequent angina before angiography, current smoking, and multivessel spasm.

AB - Abstract Objectives This study wasObjectives This study was an observational, multicenter registry to determine clinical characteristics and 24-month prognosis of patients who underwent intracoronary ergonovine provocation tests. Background The clinical characteristics and prognosis of patients who underwent the ergonovine provocation for vasospastic angina were not fully elucidated. Methods A total of 2,129 patients in the VA-KOREA (Vasospastic Angina in Korea) registry were classified into positive (n = 454), intermediate (n = 982), and negative (n = 693) groups by intracoronary ergonovine provocation tests. The 24-month incidences of cardiac death, new-onset arrhythmia, and acute coronary syndrome were determined (mean 26.7 ± 8.8 months). Results The number of smokers, frequency of angina before angiography, high-sensitivity C-reactive protein, and triglyceride were higher in the positive group than in other groups. The clinical characteristics of the intermediate and the negative groups were very similar. In the positive group, the incidences of diffuse, focal, and mixed spasm were 65.9%, 23.6%, and 10.6%. Coronary spasm was more frequently provoked on atherosclerotic segments. The 24-month incidences of cardiac death, arrhythmia, and acute coronary syndrome were low (0.9%, 1.6%, and 1.9%, respectively) in the positive group, and there was no cardiac death in the intermediate group (p = 0.02). In the positive group, frequent angina, current smoking, and multivessel spasm were independent predictors for adverse events. Conclusions The 24-month prognosis of the positive group in the intracoronary ergonovine provocation test was relatively worse than that of the intermediate group. More intensive clinical attention should be paid to vasospastic angina patients with high-risk factors including frequent angina before angiography, current smoking, and multivessel spasm.

KW - ergonovine

KW - prognosis

KW - vasospastic angina

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