The acceptable duration between occupational exposure to hepatitis B virus and hepatitis B immunoglobulin injection: Results from a Korean nationwide, multicenter study

Hyun Ha Chang, Won Kee Lee, Chisook Moon, Wonseok Choi, Hee Jung Yoon, Jieun Kim, Seong Yeol Ryu, Hyun Ah Kim, Yu Mi Jo, Ki Tae Kwon, Hye In Kim, Jang Wook Sohn, Young Kyung Yoon, Sook In Jung, Kyung Hwa Park, Hyun Hee Kwon, Mi Suk Lee, Young Keun Kim, Yeon Sook Kim, Jian HurShin Woo Kim

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1 Citation (Scopus)

Abstract

Background Postexposure prophylaxis for occupational exposure to hepatitis B virus (HBV) plays an important role in the prevention of HBV infections in health care workers (HCWs). We examined data concerning the acceptable duration between occupational exposure and administration of a hepatitis B immunoglobulin (HBIG) injection in an occupational clinical setting. Methods A retrospective analysis was conducted with data from 143 cases of HCWs exposed to HBV in 15 secondary and tertiary teaching hospitals between January 2005 and June 2013. Data were taken from the infection control records of each hospital. Results Active vaccination after HBV exposure was started in 119 cases (83.2%) and postvaccination testing for hepatitis B antibody showed positive seroconversion in 93% of cases. In 98 cases (68.5%), HBIG was administered within 24 hours after HBV exposure; however, 45 HCWs (31.5%) received an HBIG injection more than 24 hours postexposure and 2 among the 45 received an injection after 7 days. Although 31.5% received an HBIG injection more than 24 hours postexposure, no cases of seroconversion to hepatitis b antibody positivity occurred. Conclusions For susceptible HCWs, HBIG administered between 24 hours and 7 days postexposure may be as effective as administration within 24 hours in preventing occupational HBV infection.

Original languageEnglish
Pages (from-to)189-193
Number of pages5
JournalAmerican Journal of Infection Control
Volume44
Issue number2
DOIs
Publication statusPublished - 2016 Feb 1

Keywords

  • Health care workers
  • Hepatitis B virus
  • Occupational exposure
  • Postexposure prophylaxis
  • Treatment outcomes

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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    Chang, H. H., Lee, W. K., Moon, C., Choi, W., Yoon, H. J., Kim, J., Ryu, S. Y., Kim, H. A., Jo, Y. M., Kwon, K. T., Kim, H. I., Sohn, J. W., Yoon, Y. K., Jung, S. I., Park, K. H., Kwon, H. H., Lee, M. S., Kim, Y. K., Kim, Y. S., ... Kim, S. W. (2016). The acceptable duration between occupational exposure to hepatitis B virus and hepatitis B immunoglobulin injection: Results from a Korean nationwide, multicenter study. American Journal of Infection Control, 44(2), 189-193. https://doi.org/10.1016/j.ajic.2015.08.024