The activity of 2′-benzoyloxycinnamaldehyde against drug-resistant cancer cell lines

Min Chung Young, Do Yoo Young, Suk Kim Jun, Youl Lee Chang, Jung Kim Hyung

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

This study investigated the inhibitory effects of 2′- benzoyloxycinnamaldehyde (BCA) on cancer cells, including various drug-resistant cancer cell lines. To observe this activity, the anticancer drug-resistant cell lines were established by continuously exposing the parental cells to 5-fluorouracil (5-FU) and cyclophosphamide (CDDP), and examining the cells with the MTT assay and flow cytometric analysis. The BCA treatment produced similar growth inhibitory effects and apoptotic cell death on the drug-resistant cancer cells as their parental cells. The activation of the p38-mitogen activated protein kinase, an increased level of reactive oxygen species (ROS) generation and downregulation of Bcl-2 were observed in both the drug resistant and non-drug resistant cell lines. The GSH treatment effectively inhibited BCA-induced apoptosis by blocking ROS generation, suggesting that ROS is a major regulator in BCA-induced apoptotic cell death. These results suggest that BCA can be a useful drug candidate for treating drug-resistant cells.

Original languageEnglish
Pages (from-to)428-437
Number of pages10
JournalJournal of Chemotherapy
Volume19
Issue number4
DOIs
Publication statusPublished - 2007 Aug

Keywords

  • 2′-benzoyloxycinnamaldehyde
  • Anticancer drugs
  • Cancer
  • Drug resistance
  • Reactive oxygen species
  • p38-mitogen activated protein kinase

ASJC Scopus subject areas

  • Oncology
  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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