Abstract
Background: Epidural opioids are frequently combined with local anaesthetics for an additive antinociceptive effect. We investigated the efficacy of epidural fentanyl to 1.25 or 1.5mg/ ml ropivacaine for post-operative epidural analgesia in children. Methods: One hundred and eight children undergoing hypospadias repair were randomized to receive 1.25 mg/ ml ropivacaine (R1.25 group), 1.25mg/ml ropivacaine with 0.2mcg/kg/h of fentanyl (R1.25F group), 1.5 mg/ml ropivacaine (R1.5 group) or 1.5mg/ml ropivacaine with 0.2mcg/kg/h of fentanyl (R1.5F group) for post-operative epidural analgesia. The epidural catheter was threaded caudally through the L4-5 interspace. The face, legs, activity, cry, consolability (FLACC) score was assessed at every hour and at FLACC score 44, an epidural bolus of 0.5ml/ kg of ropivacaine 1.5mg/ml was given as the rescue analgesia. The incidence of side effects such as hypoxia, sedation, pruritus, nausea and/or vomiting was recorded. Results: The need for rescue analgesia was higher in the R1.25 group compared with that in the other three groups (all Po0.05). The incidence of side effects was higher in the R1.5F group compared with that in the R1.25 and R1.5 groups (both P50.010). Conclusion: The addition of 0.2mcg/kg/h fentanyl to 1.5mg/ml ropivacaine increased the incidence of side effects without improvement of analgesia in infants and children undergoing hypospadias repair. The use of plain 1.25 mg/ml ropivacaine increased the need for rescue analgesia and this could be compensated by addition of fentanyl.
| Original language | English |
|---|---|
| Pages (from-to) | 1084-1087 |
| Number of pages | 4 |
| Journal | Acta Anaesthesiologica Scandinavica |
| Volume | 53 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2009 Sep 1 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Anesthesiology and Pain Medicine
Cite this
The addition of fentanyl to 1.5 mg/ml ropivacaine has no advantage for paediatric epidural analgesia. / Cho, Jang-Eun; Kim, J. Y.; Hong, J. Y.; Kil, H. K.
In: Acta Anaesthesiologica Scandinavica, Vol. 53, No. 8, 01.09.2009, p. 1084-1087.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The addition of fentanyl to 1.5 mg/ml ropivacaine has no advantage for paediatric epidural analgesia
AU - Cho, Jang-Eun
AU - Kim, J. Y.
AU - Hong, J. Y.
AU - Kil, H. K.
PY - 2009/9/1
Y1 - 2009/9/1
N2 - Background: Epidural opioids are frequently combined with local anaesthetics for an additive antinociceptive effect. We investigated the efficacy of epidural fentanyl to 1.25 or 1.5mg/ ml ropivacaine for post-operative epidural analgesia in children. Methods: One hundred and eight children undergoing hypospadias repair were randomized to receive 1.25 mg/ ml ropivacaine (R1.25 group), 1.25mg/ml ropivacaine with 0.2mcg/kg/h of fentanyl (R1.25F group), 1.5 mg/ml ropivacaine (R1.5 group) or 1.5mg/ml ropivacaine with 0.2mcg/kg/h of fentanyl (R1.5F group) for post-operative epidural analgesia. The epidural catheter was threaded caudally through the L4-5 interspace. The face, legs, activity, cry, consolability (FLACC) score was assessed at every hour and at FLACC score 44, an epidural bolus of 0.5ml/ kg of ropivacaine 1.5mg/ml was given as the rescue analgesia. The incidence of side effects such as hypoxia, sedation, pruritus, nausea and/or vomiting was recorded. Results: The need for rescue analgesia was higher in the R1.25 group compared with that in the other three groups (all Po0.05). The incidence of side effects was higher in the R1.5F group compared with that in the R1.25 and R1.5 groups (both P50.010). Conclusion: The addition of 0.2mcg/kg/h fentanyl to 1.5mg/ml ropivacaine increased the incidence of side effects without improvement of analgesia in infants and children undergoing hypospadias repair. The use of plain 1.25 mg/ml ropivacaine increased the need for rescue analgesia and this could be compensated by addition of fentanyl.
AB - Background: Epidural opioids are frequently combined with local anaesthetics for an additive antinociceptive effect. We investigated the efficacy of epidural fentanyl to 1.25 or 1.5mg/ ml ropivacaine for post-operative epidural analgesia in children. Methods: One hundred and eight children undergoing hypospadias repair were randomized to receive 1.25 mg/ ml ropivacaine (R1.25 group), 1.25mg/ml ropivacaine with 0.2mcg/kg/h of fentanyl (R1.25F group), 1.5 mg/ml ropivacaine (R1.5 group) or 1.5mg/ml ropivacaine with 0.2mcg/kg/h of fentanyl (R1.5F group) for post-operative epidural analgesia. The epidural catheter was threaded caudally through the L4-5 interspace. The face, legs, activity, cry, consolability (FLACC) score was assessed at every hour and at FLACC score 44, an epidural bolus of 0.5ml/ kg of ropivacaine 1.5mg/ml was given as the rescue analgesia. The incidence of side effects such as hypoxia, sedation, pruritus, nausea and/or vomiting was recorded. Results: The need for rescue analgesia was higher in the R1.25 group compared with that in the other three groups (all Po0.05). The incidence of side effects was higher in the R1.5F group compared with that in the R1.25 and R1.5 groups (both P50.010). Conclusion: The addition of 0.2mcg/kg/h fentanyl to 1.5mg/ml ropivacaine increased the incidence of side effects without improvement of analgesia in infants and children undergoing hypospadias repair. The use of plain 1.25 mg/ml ropivacaine increased the need for rescue analgesia and this could be compensated by addition of fentanyl.
UR - http://www.scopus.com/inward/record.url?scp=68849102428&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=68849102428&partnerID=8YFLogxK
U2 - 10.1111/j.1399-6576.2009.02046.x
DO - 10.1111/j.1399-6576.2009.02046.x
M3 - Article
C2 - 19572930
AN - SCOPUS:68849102428
VL - 53
SP - 1084
EP - 1087
JO - Acta Anaesthesiologica Scandinavica
JF - Acta Anaesthesiologica Scandinavica
SN - 0001-5172
IS - 8
ER -