The adrenal peripheral clock

Glucocorticoid and the circadian timing system

Gi Hoon Son, Sooyoung Chung, Kyungjin Kim

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

The mammalian circadian timing system is organized in a hierarchy, with the master clock residing in the suprachiasmatic nucleus (SCN) of the hypothalamus and subsidiary peripheral clocks in other brain regions as well as peripheral tissues. Since the local oscillators in most cells contain a similar molecular makeup to that in the central pacemaker, determining the role of the peripheral clocks in the regulation of rhythmic physiology and behavior is an important issue. Glucocorticoids (GCs) are a class of multi-functional adrenal steroid hormones, which exhibit a robust circadian rhythm, with a peak linked with the onset of the daily activity phase. It has long been believed that the production and secretion of GC is primarily governed through the hypothalamus-pituitary-adrenal (HPA) neuroendocrine axis in mammals. Growing evidence, however, strongly supports the notion that the periodicity of GC involves the integrated activity of multiple regulatory mechanisms related to circadian timing system along with the classical HPA neuroendocrine regulation. The adrenal-intrinsic oscillator as well as the central pacemaker plays a pivotal role in its rhythmicity. GC influences numerous biological processes, such as metabolic, cardiovascular, immune and even higher brain functions, and also acts as a resetting signal for the ubiquitous peripheral clocks, suggesting its importance in harmonizing circadian physiology and behavior. In this review, we will therefore focus on the recent advances in our understanding of the circadian regulation of adrenal GC and its functional relevance.

Original languageEnglish
Pages (from-to)451-465
Number of pages15
JournalFrontiers in Neuroendocrinology
Volume32
Issue number4
DOIs
Publication statusPublished - 2011 Oct 1
Externally publishedYes

Fingerprint

Circadian Clocks
Glucocorticoids
Hypothalamus
Periodicity
Biological Phenomena
Suprachiasmatic Nucleus
Brain
Circadian Rhythm
Mammals
Steroids
Hormones

Keywords

  • Adrenal gland
  • Biological clock
  • Circadian rhythm
  • Glucocorticoid
  • Hypothalamus-pituitary-adrenal (HPA) axis
  • Steroidogenic acute regulatory protein (StAR)

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems

Cite this

The adrenal peripheral clock : Glucocorticoid and the circadian timing system. / Son, Gi Hoon; Chung, Sooyoung; Kim, Kyungjin.

In: Frontiers in Neuroendocrinology, Vol. 32, No. 4, 01.10.2011, p. 451-465.

Research output: Contribution to journalArticle

Son, Gi Hoon ; Chung, Sooyoung ; Kim, Kyungjin. / The adrenal peripheral clock : Glucocorticoid and the circadian timing system. In: Frontiers in Neuroendocrinology. 2011 ; Vol. 32, No. 4. pp. 451-465.
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