The adverse events of influenza A (H1N1) vaccination and its risk factors in healthcare personnel in 18 military healthcare units in Korea

Se Min Hwang, Kang Won Choe, Sang Heon Cho, Seok-Jun Yoon, Dong Ean Park, Jum Sook Kang, Min Jeong Kim, Byung-Chul Chun, Sang Min Lee

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

In this study, we characterized adverse events related to influenza A (H1N1) vaccination and studied the factors that influence the occurrence of these events. A total of 4,302 personnel in 18 military healthcare units in Korea received 0.5 ml of inactivated H1N1 vaccine. The study questionnaires were answered by 3,939 (91.6z) personnel, at both 2 weeks and 4 weeks after vaccination. Among these subjects, 3,531 (82.1z) who responded to all questions in the questionnaire were studied. After immunization, military doctors were ordered to report the occurrence of any adverse event related to the vaccine for 2 months. According to the responses of the subjects, the most prevalent events were fatigue (11.3z), pain at the injection site (8.38z), and myalgia (6.97z). Female gender, being in the age range of 20-49 years, obesity, regular alcohol consumption, and comorbidity, but not smoking status or pregnancy, were related to a high incidence of local or systemic adverse events after H1N1 vaccination. A total of 14 cases of adverse events were reported by the military doctors. In most reported cases, the subjects had fever in addition to the primary adverse event, and one patient was diagnosed with pneumonia. In conclusion, the overall burden of adverse events related to influenza A (H1N1) vaccination was not inconsequential, but most symptoms were mild. Female gender, middle-age range of 20-49 years, obesity, regular alcohol consumption, and comorbidity were risk factors for the occurrence of adverse events after H1N1 vaccination.

Original languageEnglish
Pages (from-to)183-189
Number of pages7
JournalJapanese Journal of Infectious Diseases
Volume64
Issue number3
Publication statusPublished - 2011 Jun 10

Fingerprint

Korea
Human Influenza
Vaccination
Delivery of Health Care
Alcohol Drinking
Comorbidity
Obesity
Inactivated Vaccines
Myalgia
Fatigue
Immunization
Pneumonia
Fever
Vaccines
Smoking
Pain
Pregnancy
Injections
Incidence
Surveys and Questionnaires

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

The adverse events of influenza A (H1N1) vaccination and its risk factors in healthcare personnel in 18 military healthcare units in Korea. / Hwang, Se Min; Choe, Kang Won; Cho, Sang Heon; Yoon, Seok-Jun; Park, Dong Ean; Kang, Jum Sook; Kim, Min Jeong; Chun, Byung-Chul; Lee, Sang Min.

In: Japanese Journal of Infectious Diseases, Vol. 64, No. 3, 10.06.2011, p. 183-189.

Research output: Contribution to journalArticle

Hwang, Se Min ; Choe, Kang Won ; Cho, Sang Heon ; Yoon, Seok-Jun ; Park, Dong Ean ; Kang, Jum Sook ; Kim, Min Jeong ; Chun, Byung-Chul ; Lee, Sang Min. / The adverse events of influenza A (H1N1) vaccination and its risk factors in healthcare personnel in 18 military healthcare units in Korea. In: Japanese Journal of Infectious Diseases. 2011 ; Vol. 64, No. 3. pp. 183-189.
@article{b71b0f5ff149417db64156de8d77f0fe,
title = "The adverse events of influenza A (H1N1) vaccination and its risk factors in healthcare personnel in 18 military healthcare units in Korea",
abstract = "In this study, we characterized adverse events related to influenza A (H1N1) vaccination and studied the factors that influence the occurrence of these events. A total of 4,302 personnel in 18 military healthcare units in Korea received 0.5 ml of inactivated H1N1 vaccine. The study questionnaires were answered by 3,939 (91.6z) personnel, at both 2 weeks and 4 weeks after vaccination. Among these subjects, 3,531 (82.1z) who responded to all questions in the questionnaire were studied. After immunization, military doctors were ordered to report the occurrence of any adverse event related to the vaccine for 2 months. According to the responses of the subjects, the most prevalent events were fatigue (11.3z), pain at the injection site (8.38z), and myalgia (6.97z). Female gender, being in the age range of 20-49 years, obesity, regular alcohol consumption, and comorbidity, but not smoking status or pregnancy, were related to a high incidence of local or systemic adverse events after H1N1 vaccination. A total of 14 cases of adverse events were reported by the military doctors. In most reported cases, the subjects had fever in addition to the primary adverse event, and one patient was diagnosed with pneumonia. In conclusion, the overall burden of adverse events related to influenza A (H1N1) vaccination was not inconsequential, but most symptoms were mild. Female gender, middle-age range of 20-49 years, obesity, regular alcohol consumption, and comorbidity were risk factors for the occurrence of adverse events after H1N1 vaccination.",
author = "Hwang, {Se Min} and Choe, {Kang Won} and Cho, {Sang Heon} and Seok-Jun Yoon and Park, {Dong Ean} and Kang, {Jum Sook} and Kim, {Min Jeong} and Byung-Chul Chun and Lee, {Sang Min}",
year = "2011",
month = "6",
day = "10",
language = "English",
volume = "64",
pages = "183--189",
journal = "Japanese Journal of Infectious Diseases",
issn = "1344-6304",
publisher = "National Institute of Health",
number = "3",

}

TY - JOUR

T1 - The adverse events of influenza A (H1N1) vaccination and its risk factors in healthcare personnel in 18 military healthcare units in Korea

AU - Hwang, Se Min

AU - Choe, Kang Won

AU - Cho, Sang Heon

AU - Yoon, Seok-Jun

AU - Park, Dong Ean

AU - Kang, Jum Sook

AU - Kim, Min Jeong

AU - Chun, Byung-Chul

AU - Lee, Sang Min

PY - 2011/6/10

Y1 - 2011/6/10

N2 - In this study, we characterized adverse events related to influenza A (H1N1) vaccination and studied the factors that influence the occurrence of these events. A total of 4,302 personnel in 18 military healthcare units in Korea received 0.5 ml of inactivated H1N1 vaccine. The study questionnaires were answered by 3,939 (91.6z) personnel, at both 2 weeks and 4 weeks after vaccination. Among these subjects, 3,531 (82.1z) who responded to all questions in the questionnaire were studied. After immunization, military doctors were ordered to report the occurrence of any adverse event related to the vaccine for 2 months. According to the responses of the subjects, the most prevalent events were fatigue (11.3z), pain at the injection site (8.38z), and myalgia (6.97z). Female gender, being in the age range of 20-49 years, obesity, regular alcohol consumption, and comorbidity, but not smoking status or pregnancy, were related to a high incidence of local or systemic adverse events after H1N1 vaccination. A total of 14 cases of adverse events were reported by the military doctors. In most reported cases, the subjects had fever in addition to the primary adverse event, and one patient was diagnosed with pneumonia. In conclusion, the overall burden of adverse events related to influenza A (H1N1) vaccination was not inconsequential, but most symptoms were mild. Female gender, middle-age range of 20-49 years, obesity, regular alcohol consumption, and comorbidity were risk factors for the occurrence of adverse events after H1N1 vaccination.

AB - In this study, we characterized adverse events related to influenza A (H1N1) vaccination and studied the factors that influence the occurrence of these events. A total of 4,302 personnel in 18 military healthcare units in Korea received 0.5 ml of inactivated H1N1 vaccine. The study questionnaires were answered by 3,939 (91.6z) personnel, at both 2 weeks and 4 weeks after vaccination. Among these subjects, 3,531 (82.1z) who responded to all questions in the questionnaire were studied. After immunization, military doctors were ordered to report the occurrence of any adverse event related to the vaccine for 2 months. According to the responses of the subjects, the most prevalent events were fatigue (11.3z), pain at the injection site (8.38z), and myalgia (6.97z). Female gender, being in the age range of 20-49 years, obesity, regular alcohol consumption, and comorbidity, but not smoking status or pregnancy, were related to a high incidence of local or systemic adverse events after H1N1 vaccination. A total of 14 cases of adverse events were reported by the military doctors. In most reported cases, the subjects had fever in addition to the primary adverse event, and one patient was diagnosed with pneumonia. In conclusion, the overall burden of adverse events related to influenza A (H1N1) vaccination was not inconsequential, but most symptoms were mild. Female gender, middle-age range of 20-49 years, obesity, regular alcohol consumption, and comorbidity were risk factors for the occurrence of adverse events after H1N1 vaccination.

UR - http://www.scopus.com/inward/record.url?scp=79958036399&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79958036399&partnerID=8YFLogxK

M3 - Article

VL - 64

SP - 183

EP - 189

JO - Japanese Journal of Infectious Diseases

JF - Japanese Journal of Infectious Diseases

SN - 1344-6304

IS - 3

ER -