The amount of hepatitis B virus (HBV) DNA has no correlationship with aminotransferases and multiple HBV mutants coexist in chronic hepatitis B patients

I. Kang, W. K. Keum, J. Ha, L. Y. Khil, I. S. Kwak, J. Y. Kim, J. M. Kim, H. W. Baek, M. T. Yang, Sung-Gil Chi, J. H. Park, S. M. Kim, H. J. Woo, Y. S. Jeong, Y. I. Lee, S. S. Kim

Research output: Contribution to journalArticle

Abstract

We tried to semiquantitize HBV DNA and reevaluate how the amount of HBV DNA affects the aminotransferases in blood using 60 chronic hepatitis B patients who were divided into 6 groups depending on HBsAg, HbeAg/Ab and aminotransferases. Our results showed that the amount of HBV DNA has no correlationship with aminotransferases in chronic hepatitis B patients whose HBsAg and HBeAg are both positive. However, the amount of HBV DNA is generally in low level in HbsAg (+), HBeAb (+) patients whose aminotransferases are within a normal range. In contrast, the amount of HBV DNA and aminotransferases has no correlationship in HBsAg (+), HBeAb (+) patients when aminotransferases are high. To find multiple HBV mutants in a single patient and diverse mutant populations in chronic hepatitis B patients, we analyzed the amplifed PCR products of HBV core region using single strand conformational polymorphysm (SSCP) and DNA sequecing. Our results showed that multiple HBV mutants coexist in a single patient and that t[BV mutant populations are different from patients to patients. These observation suggest that enormous populations of ttBV mutants exist in chronic hepatitis B patients.

Original languageEnglish
JournalFASEB Journal
Volume11
Issue number9
Publication statusPublished - 1997 Dec 1
Externally publishedYes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

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  • Cite this

    Kang, I., Keum, W. K., Ha, J., Khil, L. Y., Kwak, I. S., Kim, J. Y., Kim, J. M., Baek, H. W., Yang, M. T., Chi, S-G., Park, J. H., Kim, S. M., Woo, H. J., Jeong, Y. S., Lee, Y. I., & Kim, S. S. (1997). The amount of hepatitis B virus (HBV) DNA has no correlationship with aminotransferases and multiple HBV mutants coexist in chronic hepatitis B patients. FASEB Journal, 11(9).