The amount of hepatitis B virus (HBV) DNA has no correlationship with aminotransferases and multiple HBV mutants coexist in chronic hepatitis B patients

I. Kang; W. K. Keum; J. Ha; L. Y. Khil; I. S. Kwak; J. Y. Kim; J. M. Kim; H. W. Baek; M. T. Yang; Sung-Gil Chi; J. H. Park; S. M. Kim; H. J. Woo; Y. S. Jeong; Y. I. Lee; S. S. Kim

The amount of hepatitis B virus (HBV) DNA has no correlationship with aminotransferases and multiple HBV mutants coexist in chronic hepatitis B patients

I. Kang, W. K. Keum, J. Ha, L. Y. Khil, I. S. Kwak, J. Y. Kim, J. M. Kim, H. W. Baek, M. T. Yang, Sung-Gil Chi, J. H. Park, S. M. Kim, H. J. Woo, Y. S. Jeong, Y. I. Lee, S. S. Kim

Research output: Contribution to journal › Article

Abstract

We tried to semiquantitize HBV DNA and reevaluate how the amount of HBV DNA affects the aminotransferases in blood using 60 chronic hepatitis B patients who were divided into 6 groups depending on HBsAg, HbeAg/Ab and aminotransferases. Our results showed that the amount of HBV DNA has no correlationship with aminotransferases in chronic hepatitis B patients whose HBsAg and HBeAg are both positive. However, the amount of HBV DNA is generally in low level in HbsAg (+), HBeAb (+) patients whose aminotransferases are within a normal range. In contrast, the amount of HBV DNA and aminotransferases has no correlationship in HBsAg (+), HBeAb (+) patients when aminotransferases are high. To find multiple HBV mutants in a single patient and diverse mutant populations in chronic hepatitis B patients, we analyzed the amplifed PCR products of HBV core region using single strand conformational polymorphysm (SSCP) and DNA sequecing. Our results showed that multiple HBV mutants coexist in a single patient and that t[BV mutant populations are different from patients to patients. These observation suggest that enormous populations of ttBV mutants exist in chronic hepatitis B patients.

Original language	English
Journal	FASEB Journal
Volume	11
Issue number	9
Publication status	Published - 1997 Dec 1
Externally published	Yes

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ASJC Scopus subject areas

Agricultural and Biological Sciences (miscellaneous)
Biochemistry, Genetics and Molecular Biology(all)
Biochemistry
Cell Biology

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Kang, I., Keum, W. K., Ha, J., Khil, L. Y., Kwak, I. S., Kim, J. Y., Kim, J. M., Baek, H. W., Yang, M. T., Chi, S-G., Park, J. H., Kim, S. M., Woo, H. J., Jeong, Y. S., Lee, Y. I., & Kim, S. S. (1997). The amount of hepatitis B virus (HBV) DNA has no correlationship with aminotransferases and multiple HBV mutants coexist in chronic hepatitis B patients. FASEB Journal, 11(9).

The amount of hepatitis B virus (HBV) DNA has no correlationship with aminotransferases and multiple HBV mutants coexist in chronic hepatitis B patients. / Kang, I.; Keum, W. K.; Ha, J.; Khil, L. Y.; Kwak, I. S.; Kim, J. Y.; Kim, J. M.; Baek, H. W.; Yang, M. T.; Chi, Sung-Gil; Park, J. H.; Kim, S. M.; Woo, H. J.; Jeong, Y. S.; Lee, Y. I.; Kim, S. S.

In: FASEB Journal, Vol. 11, No. 9, 01.12.1997.

Research output: Contribution to journal › Article

Kang, I. ; Keum, W. K. ; Ha, J. ; Khil, L. Y. ; Kwak, I. S. ; Kim, J. Y. ; Kim, J. M. ; Baek, H. W. ; Yang, M. T. ; Chi, Sung-Gil ; Park, J. H. ; Kim, S. M. ; Woo, H. J. ; Jeong, Y. S. ; Lee, Y. I. ; Kim, S. S. / The amount of hepatitis B virus (HBV) DNA has no correlationship with aminotransferases and multiple HBV mutants coexist in chronic hepatitis B patients. In: FASEB Journal. 1997 ; Vol. 11, No. 9.

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abstract = "We tried to semiquantitize HBV DNA and reevaluate how the amount of HBV DNA affects the aminotransferases in blood using 60 chronic hepatitis B patients who were divided into 6 groups depending on HBsAg, HbeAg/Ab and aminotransferases. Our results showed that the amount of HBV DNA has no correlationship with aminotransferases in chronic hepatitis B patients whose HBsAg and HBeAg are both positive. However, the amount of HBV DNA is generally in low level in HbsAg (+), HBeAb (+) patients whose aminotransferases are within a normal range. In contrast, the amount of HBV DNA and aminotransferases has no correlationship in HBsAg (+), HBeAb (+) patients when aminotransferases are high. To find multiple HBV mutants in a single patient and diverse mutant populations in chronic hepatitis B patients, we analyzed the amplifed PCR products of HBV core region using single strand conformational polymorphysm (SSCP) and DNA sequecing. Our results showed that multiple HBV mutants coexist in a single patient and that t[BV mutant populations are different from patients to patients. These observation suggest that enormous populations of ttBV mutants exist in chronic hepatitis B patients.",

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The amount of hepatitis B virus (HBV) DNA has no correlationship with aminotransferases and multiple HBV mutants coexist in chronic hepatitis B patients

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