The amount of hepatitis B virus (HBV) DNA has no correlationship with aminotransferases and multiple HBV mutants coexist in chronic hepatitis B patients

I. Kang, W. K. Keum, J. Ha, L. Y. Khil, I. S. Kwak, J. Y. Kim, J. M. Kim, H. W. Baek, M. T. Yang, S. G. Chi, J. H. Park, S. M. Kim, H. J. Woo, Y. S. Jeong, Y. I. Lee, S. S. Kim

Research output: Contribution to journalArticlepeer-review

Abstract

We tried to semiquantitize HBV DNA and reevaluate how the amount of HBV DNA affects the aminotransferases in blood using 60 chronic hepatitis B patients who were divided into 6 groups depending on HBsAg, HbeAg/Ab and aminotransferases. Our results showed that the amount of HBV DNA has no correlationship with aminotransferases in chronic hepatitis B patients whose HBsAg and HBeAg are both positive. However, the amount of HBV DNA is generally in low level in HbsAg (+), HBeAb (+) patients whose aminotransferases are within a normal range. In contrast, the amount of HBV DNA and aminotransferases has no correlationship in HBsAg (+), HBeAb (+) patients when aminotransferases are high. To find multiple HBV mutants in a single patient and diverse mutant populations in chronic hepatitis B patients, we analyzed the amplifed PCR products of HBV core region using single strand conformational polymorphysm (SSCP) and DNA sequecing. Our results showed that multiple HBV mutants coexist in a single patient and that t[BV mutant populations are different from patients to patients. These observation suggest that enormous populations of ttBV mutants exist in chronic hepatitis B patients.

Original languageEnglish
Pages (from-to)A1437
JournalFASEB Journal
Volume11
Issue number9
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics

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