The analgesic effect of remifentanil on prevention of withdrawal response associated with the injection of rocuronium in children: No evidence for a peripheral action

J. R. Yoon, Y. Jeon, Young Yoo, H. J. Shin, J. H. Ahn, Choon Hak Lim

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8 Citations (Scopus)


Remifentanil pre-treatment has been reported to decrease the incidence of rocuronium injection-associated withdrawal movement. This study was designed to explore the site of action of remifentanil for reducing withdrawal response during rocuronium injection in children. Ninety-six paediatric patients were randomly assigned to three groups. After induction of anaesthesia with 5 mg/kg 2.5% thiopental sodium, 2 ml saline (placebo group) or 0.5 μg/kg remifentanil (group R), was injected intravenously 1 min before 0.6 mg/kg rocuronium. In a third group(group R′), the venous retention of 0.5 μg/kg remifentanil was maintained for 30 s followed by tourniquet release and injection of 0.6 mg/kg rocuronium. Withdrawal response was graded using a four-point scale. The incidence of withdrawal movement after rocuronium administration was 94%, 22% and 81% in the placebo, R, and R′ groups, respectively. This study demonstrated that the pre-treatment effect of remifentanil for reducing rocuronium-associated withdrawal response occurs mainly through a central action.

Original languageEnglish
Pages (from-to)1795-1800
Number of pages6
JournalJournal of International Medical Research
Issue number5
Publication statusPublished - 2010 Jan 1



  • Children
  • Pain
  • Remifentanil
  • Rocuronium
  • Withdrawal response

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Biochemistry, medical

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