The analysis of Plasmodium vivax Duffy receptor binding domain gene sequence from resurgent Korea isolates

In Suh, Kenneth J. Hoffman, Sang Hyun Kim, Ki-Joon Song, Jin Won Song, Joon Lee, Chae Seung Lim

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The Duffy binding domain gene structures of Plasmodium vivax facilitate the invasion of erythrocytes. Human erythrocytes that lack Duffy blood group antigens are resistant to invasion by P. vivax. We have sequenced the Duffy binding domain gene from eight P. vivax isolates collected from malaria cases in South Korea. When compared to isolates from other regions in the world, the amino acid sequences of the Korean isolates showed unique variations in region II. From 606 sequenced amino acids, 32 variations were found. Of these, three variations were regularly found in positions 424, 437 and 503 of the Sal-1 amino acid sequence. In region III, six isolates had a loss of the 30 bp (FAESTKSAE) insert. However, six isolates had 6 bp (SD) inserts at the end of region III. Two cases had a reverse pattern. Our results suggest that the P. vivax currently found in South Korea are unique when compared to other isolates and can be divided, by the analysis of their molecular structure, into two strains.

Original languageEnglish
Pages (from-to)1007-1010
Number of pages4
JournalParasitology Research
Volume87
Issue number12
Publication statusPublished - 2001 Nov 17

Fingerprint

Plasmodium vivax
Korea
Korean Peninsula
nucleotide sequences
Republic of Korea
receptors
South Korea
Genes
Amino Acid Sequence
erythrocytes
amino acid sequences
Erythrocytes
blood group antigens
Blood Group Antigens
Molecular Structure
chemical structure
malaria
Malaria
genes
Amino Acids

ASJC Scopus subject areas

  • Parasitology

Cite this

The analysis of Plasmodium vivax Duffy receptor binding domain gene sequence from resurgent Korea isolates. / Suh, In; Hoffman, Kenneth J.; Kim, Sang Hyun; Song, Ki-Joon; Song, Jin Won; Lee, Joon; Lim, Chae Seung.

In: Parasitology Research, Vol. 87, No. 12, 17.11.2001, p. 1007-1010.

Research output: Contribution to journalArticle

@article{3ab5a868443a407f9ff861b0049ec35e,
title = "The analysis of Plasmodium vivax Duffy receptor binding domain gene sequence from resurgent Korea isolates",
abstract = "The Duffy binding domain gene structures of Plasmodium vivax facilitate the invasion of erythrocytes. Human erythrocytes that lack Duffy blood group antigens are resistant to invasion by P. vivax. We have sequenced the Duffy binding domain gene from eight P. vivax isolates collected from malaria cases in South Korea. When compared to isolates from other regions in the world, the amino acid sequences of the Korean isolates showed unique variations in region II. From 606 sequenced amino acids, 32 variations were found. Of these, three variations were regularly found in positions 424, 437 and 503 of the Sal-1 amino acid sequence. In region III, six isolates had a loss of the 30 bp (FAESTKSAE) insert. However, six isolates had 6 bp (SD) inserts at the end of region III. Two cases had a reverse pattern. Our results suggest that the P. vivax currently found in South Korea are unique when compared to other isolates and can be divided, by the analysis of their molecular structure, into two strains.",
author = "In Suh and Hoffman, {Kenneth J.} and Kim, {Sang Hyun} and Ki-Joon Song and Song, {Jin Won} and Joon Lee and Lim, {Chae Seung}",
year = "2001",
month = "11",
day = "17",
language = "English",
volume = "87",
pages = "1007--1010",
journal = "Parasitology Research",
issn = "0932-0113",
publisher = "Springer Verlag",
number = "12",

}

TY - JOUR

T1 - The analysis of Plasmodium vivax Duffy receptor binding domain gene sequence from resurgent Korea isolates

AU - Suh, In

AU - Hoffman, Kenneth J.

AU - Kim, Sang Hyun

AU - Song, Ki-Joon

AU - Song, Jin Won

AU - Lee, Joon

AU - Lim, Chae Seung

PY - 2001/11/17

Y1 - 2001/11/17

N2 - The Duffy binding domain gene structures of Plasmodium vivax facilitate the invasion of erythrocytes. Human erythrocytes that lack Duffy blood group antigens are resistant to invasion by P. vivax. We have sequenced the Duffy binding domain gene from eight P. vivax isolates collected from malaria cases in South Korea. When compared to isolates from other regions in the world, the amino acid sequences of the Korean isolates showed unique variations in region II. From 606 sequenced amino acids, 32 variations were found. Of these, three variations were regularly found in positions 424, 437 and 503 of the Sal-1 amino acid sequence. In region III, six isolates had a loss of the 30 bp (FAESTKSAE) insert. However, six isolates had 6 bp (SD) inserts at the end of region III. Two cases had a reverse pattern. Our results suggest that the P. vivax currently found in South Korea are unique when compared to other isolates and can be divided, by the analysis of their molecular structure, into two strains.

AB - The Duffy binding domain gene structures of Plasmodium vivax facilitate the invasion of erythrocytes. Human erythrocytes that lack Duffy blood group antigens are resistant to invasion by P. vivax. We have sequenced the Duffy binding domain gene from eight P. vivax isolates collected from malaria cases in South Korea. When compared to isolates from other regions in the world, the amino acid sequences of the Korean isolates showed unique variations in region II. From 606 sequenced amino acids, 32 variations were found. Of these, three variations were regularly found in positions 424, 437 and 503 of the Sal-1 amino acid sequence. In region III, six isolates had a loss of the 30 bp (FAESTKSAE) insert. However, six isolates had 6 bp (SD) inserts at the end of region III. Two cases had a reverse pattern. Our results suggest that the P. vivax currently found in South Korea are unique when compared to other isolates and can be divided, by the analysis of their molecular structure, into two strains.

UR - http://www.scopus.com/inward/record.url?scp=0034767692&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034767692&partnerID=8YFLogxK

M3 - Article

C2 - 11763429

AN - SCOPUS:0034767692

VL - 87

SP - 1007

EP - 1010

JO - Parasitology Research

JF - Parasitology Research

SN - 0932-0113

IS - 12

ER -