TY - JOUR
T1 - The analysis of Plasmodium vivax Duffy receptor binding domain gene sequence from resurgent Korea isolates
AU - Suh, In
AU - Hoffman, Kenneth J.
AU - Kim, Sang Hyun
AU - Song, Ki Joon
AU - Song, Jin Won
AU - Lee, Joon
AU - Lim, Chae
N1 - Funding Information:
Acknowledgement This work was supported by a grant from the health technology plan of the Ministry of Health and Welfare, Republic of Korea (Grant No HMP-99-M-04–0002).
PY - 2001
Y1 - 2001
N2 - The Duffy binding domain gene structures of Plasmodium vivax facilitate the invasion of erythrocytes. Human erythrocytes that lack Duffy blood group antigens are resistant to invasion by P. vivax. We have sequenced the Duffy binding domain gene from eight P. vivax isolates collected from malaria cases in South Korea. When compared to isolates from other regions in the world, the amino acid sequences of the Korean isolates showed unique variations in region II. From 606 sequenced amino acids, 32 variations were found. Of these, three variations were regularly found in positions 424, 437 and 503 of the Sal-1 amino acid sequence. In region III, six isolates had a loss of the 30 bp (FAESTKSAE) insert. However, six isolates had 6 bp (SD) inserts at the end of region III. Two cases had a reverse pattern. Our results suggest that the P. vivax currently found in South Korea are unique when compared to other isolates and can be divided, by the analysis of their molecular structure, into two strains.
AB - The Duffy binding domain gene structures of Plasmodium vivax facilitate the invasion of erythrocytes. Human erythrocytes that lack Duffy blood group antigens are resistant to invasion by P. vivax. We have sequenced the Duffy binding domain gene from eight P. vivax isolates collected from malaria cases in South Korea. When compared to isolates from other regions in the world, the amino acid sequences of the Korean isolates showed unique variations in region II. From 606 sequenced amino acids, 32 variations were found. Of these, three variations were regularly found in positions 424, 437 and 503 of the Sal-1 amino acid sequence. In region III, six isolates had a loss of the 30 bp (FAESTKSAE) insert. However, six isolates had 6 bp (SD) inserts at the end of region III. Two cases had a reverse pattern. Our results suggest that the P. vivax currently found in South Korea are unique when compared to other isolates and can be divided, by the analysis of their molecular structure, into two strains.
UR - http://www.scopus.com/inward/record.url?scp=0034767692&partnerID=8YFLogxK
U2 - 10.1007/s004360100478
DO - 10.1007/s004360100478
M3 - Article
C2 - 11763429
AN - SCOPUS:0034767692
VL - 87
SP - 1007
EP - 1010
JO - Parasitology Research
JF - Parasitology Research
SN - 0932-0113
IS - 12
ER -
