The angiogenic sprouting of endothelial cells in three-dimensional collagen gel matrix

Hyo Eun Jeong; Har Rim Seo; Hyung Joon Joo; Seok Chung

The angiogenic sprouting of endothelial cells in three-dimensional collagen gel matrix

Hyo Eun Jeong, Har Rim Seo, Hyung Joon Joo, Seok Chung

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

It is well known that angiogenesis is an essential biological event. To understand fully how the blood vessel grows and functions in the angiogenic process, we should consider the construction of in vivo-like environment, such as three- dimensional (3D) extracellular matrix (ECM). However, most of in vitro studies of the angiogenesis have been relied on two-dimensional (2D) culture or 3D Matrigel culture platforms, which do not account for the in vivo situations. To overcome these limitations in the studies of the angiogenesis, we used a simple microfluidic method incorporating the 3D ECM into the surrounding endothelial cells (ECs) channel.

Original language	English
Title of host publication	17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
Publisher	Chemical and Biological Microsystems Society
Pages	434-436
Number of pages	3
Volume	1
ISBN (Print)	9781632666246
Publication status	Published - 2013 Jan 1
Event	17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 - Freiburg, Germany Duration: 2013 Oct 27 → 2013 Oct 31

Other

Other	17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
Country	Germany
City	Freiburg
Period	13/10/27 → 13/10/31

ASJC Scopus subject areas

Bioengineering

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The angiogenic sprouting of endothelial cells in three-dimensional collagen gel matrix. / Jeong, Hyo Eun; Seo, Har Rim; Joo, Hyung Joon; Chung, Seok.

17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013. Vol. 1 Chemical and Biological Microsystems Society, 2013. p. 434-436.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Jeong, HE, Seo, HR, Joo, HJ & Chung, S 2013, The angiogenic sprouting of endothelial cells in three-dimensional collagen gel matrix. in 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013. vol. 1, Chemical and Biological Microsystems Society, pp. 434-436, 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013, Freiburg, Germany, 13/10/27.

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abstract = "It is well known that angiogenesis is an essential biological event. To understand fully how the blood vessel grows and functions in the angiogenic process, we should consider the construction of in vivo-like environment, such as three- dimensional (3D) extracellular matrix (ECM). However, most of in vitro studies of the angiogenesis have been relied on two-dimensional (2D) culture or 3D Matrigel culture platforms, which do not account for the in vivo situations. To overcome these limitations in the studies of the angiogenesis, we used a simple microfluidic method incorporating the 3D ECM into the surrounding endothelial cells (ECs) channel.",

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N2 - It is well known that angiogenesis is an essential biological event. To understand fully how the blood vessel grows and functions in the angiogenic process, we should consider the construction of in vivo-like environment, such as three- dimensional (3D) extracellular matrix (ECM). However, most of in vitro studies of the angiogenesis have been relied on two-dimensional (2D) culture or 3D Matrigel culture platforms, which do not account for the in vivo situations. To overcome these limitations in the studies of the angiogenesis, we used a simple microfluidic method incorporating the 3D ECM into the surrounding endothelial cells (ECs) channel.

AB - It is well known that angiogenesis is an essential biological event. To understand fully how the blood vessel grows and functions in the angiogenic process, we should consider the construction of in vivo-like environment, such as three- dimensional (3D) extracellular matrix (ECM). However, most of in vitro studies of the angiogenesis have been relied on two-dimensional (2D) culture or 3D Matrigel culture platforms, which do not account for the in vivo situations. To overcome these limitations in the studies of the angiogenesis, we used a simple microfluidic method incorporating the 3D ECM into the surrounding endothelial cells (ECs) channel.

KW - Collagen

KW - ECM

KW - Endothelial cells(ECs)

KW - Microfluidics

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The angiogenic sprouting of endothelial cells in three-dimensional collagen gel matrix

Abstract

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ASJC Scopus subject areas

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