The angiogenic sprouting of endothelial cells in three-dimensional collagen gel matrix

Hyo Eun Jeong, Har Rim Seo, Hyung Joon Joo, Seok Chung

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

It is well known that angiogenesis is an essential biological event. To understand fully how the blood vessel grows and functions in the angiogenic process, we should consider the construction of in vivo-like environment, such as three- dimensional (3D) extracellular matrix (ECM). However, most of in vitro studies of the angiogenesis have been relied on two-dimensional (2D) culture or 3D Matrigel culture platforms, which do not account for the in vivo situations. To overcome these limitations in the studies of the angiogenesis, we used a simple microfluidic method incorporating the 3D ECM into the surrounding endothelial cells (ECs) channel.

Original languageEnglish
Title of host publication17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
PublisherChemical and Biological Microsystems Society
Pages434-436
Number of pages3
Volume1
ISBN (Print)9781632666246
Publication statusPublished - 2013 Jan 1
Event17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 - Freiburg, Germany
Duration: 2013 Oct 272013 Oct 31

Other

Other17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
CountryGermany
CityFreiburg
Period13/10/2713/10/31

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ASJC Scopus subject areas

  • Bioengineering

Cite this

Jeong, H. E., Seo, H. R., Joo, H. J., & Chung, S. (2013). The angiogenic sprouting of endothelial cells in three-dimensional collagen gel matrix. In 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 (Vol. 1, pp. 434-436). Chemical and Biological Microsystems Society.