The anti-diabetic effects of Kocat-D1 on streptozotocin-induced diabetic rats

Hye Jin Won, Hyun Sun Lee, Jong Tak Kim, Chung Oui Hong, Yun Chang Koo, Kwang Won Lee

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

This study was conducted to investigate the anti-diabetic activity of Kocat-D1, which is widely used in traditional medicine to treat diabetes in Shandong, China. Sprague Dawley rats (8 weeks of age) were separated into 4 groups: a normal control, streptozotocin (STZ)-induced diabetic rat group (DM control), Kocat-D1-1 (diabetic rat treated with 0.25 g/kg/day hot water extract), and Kocat-D1-2 (diabetic rat treated with 1 g/kg/day hot water extract). After eight weeks of treatment, the fasting blood glucose levels of the Kocat-D1-1 (334.3±32.9 mg/dL) and Kocat-D1-2 group (259.5±35.0 mg/dL) were significantly lower when compared to the DM control group (451±42.6 mg/dL). Furthermore, the levels of glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), albumin and high-density lipoprotein (HDL) cholesterol in the serum of the Kocat-D1-2 group were significantly normalized when compared to the DM control group. However, significant differences were not observed between the Kocat-D1-1 group and the DM control group. Histochemical staining of the liver of the Kocat-D1-2 group revealed no fat accumulation. The insulin level was significantly upregulated in the Kocat-D1-2 group (0.13±0.02 ng/mL) when compared to the DM control group (0.05±0.04 ng/mL). The relative volume of β-cells in the pancreas of the Kocat-D1-2 group (49.4±4.2%) also increased significantly when compared to the DM control group (12.9±7.9%). These results suggest that Kocat-D1 exerts an anti-hyperglycemic effect through the enhancement of insulin secretion.

Original languageEnglish
Pages (from-to)204-209
Number of pages6
JournalKorean Journal of Food Science and Technology
Volume42
Issue number2
Publication statusPublished - 2010 Dec 1

Fingerprint

glycemic effect
streptozotocin
Streptozocin
Control Groups
rats
Transaminases
China
Glutamic Acid
insulin secretion
extracts
traditional medicine
alanine transaminase
high density lipoprotein cholesterol
pancreas
aspartate transaminase
Insulin
blood glucose
fasting
albumins
diabetes

Keywords

  • Anti-hyperglycemia
  • Cucurbitaceae
  • Diabetic rat
  • Insulin
  • Streptozotocin
  • Traditional medicine

ASJC Scopus subject areas

  • Food Science
  • Biotechnology
  • Applied Microbiology and Biotechnology

Cite this

The anti-diabetic effects of Kocat-D1 on streptozotocin-induced diabetic rats. / Won, Hye Jin; Lee, Hyun Sun; Kim, Jong Tak; Hong, Chung Oui; Koo, Yun Chang; Lee, Kwang Won.

In: Korean Journal of Food Science and Technology, Vol. 42, No. 2, 01.12.2010, p. 204-209.

Research output: Contribution to journalArticle

Won, Hye Jin ; Lee, Hyun Sun ; Kim, Jong Tak ; Hong, Chung Oui ; Koo, Yun Chang ; Lee, Kwang Won. / The anti-diabetic effects of Kocat-D1 on streptozotocin-induced diabetic rats. In: Korean Journal of Food Science and Technology. 2010 ; Vol. 42, No. 2. pp. 204-209.
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