The anti-influenza virus effect of Phellinus igniarius extract

Sangmoo Lee, Jin Il Kim, Jun Heo, Ilseob Lee, Sehee Park, Min Woong Hwang, Joon Yong Bae, Mee Sook Park, Hyoung Jin Park, Man-Seong Park

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Herbal medicine has been used in the orient for thousands of years to treat large and small ailments, including microbial infections. Although there are treatments for influenza virus infection, there is no treatment for drug-resistant viruses. It is time that we explored and exploited the multi-component nature of herbal extracts as multi-drug combination therapies. Here, we present data on the anti-influenza virus effect of a medicinal mushroom, Phellinus igniarius. The P. igniarius water extract was effective against influenza A and B viruses, including 2009 pandemic H1N1, human H3N2, avian H9N2, and oseltamivir-resistant H1N1 viruses. Virological assays revealed that the extract may interfere with one or more early events in the influenza virus replication cycle, including viral attachment to the target cell. Therefore, our results provide new insights into the use of P. igniarius as an anti-influenza medicine.

Original languageEnglish
Pages (from-to)676-681
Number of pages6
JournalJournal of Microbiology
Volume51
Issue number5
DOIs
Publication statusPublished - 2013 Oct 1
Externally publishedYes

Fingerprint

Orthomyxoviridae
Influenza B virus
Oseltamivir
H1N1 Subtype Influenza A Virus
Herbal Medicine
Agaricales
Influenza A virus
Pandemics
Virus Diseases
Virus Replication
Combination Drug Therapy
Human Influenza
Medicine
Viruses
Water
Therapeutics
Infection
Pharmaceutical Preparations

Keywords

  • antiviral
  • herbal
  • influenza
  • multi-drug
  • Phellinus igniarius

ASJC Scopus subject areas

  • Microbiology
  • Applied Microbiology and Biotechnology

Cite this

The anti-influenza virus effect of Phellinus igniarius extract. / Lee, Sangmoo; Kim, Jin Il; Heo, Jun; Lee, Ilseob; Park, Sehee; Hwang, Min Woong; Bae, Joon Yong; Park, Mee Sook; Park, Hyoung Jin; Park, Man-Seong.

In: Journal of Microbiology, Vol. 51, No. 5, 01.10.2013, p. 676-681.

Research output: Contribution to journalArticle

Lee, S, Kim, JI, Heo, J, Lee, I, Park, S, Hwang, MW, Bae, JY, Park, MS, Park, HJ & Park, M-S 2013, 'The anti-influenza virus effect of Phellinus igniarius extract', Journal of Microbiology, vol. 51, no. 5, pp. 676-681. https://doi.org/10.1007/s12275-013-3384-2
Lee, Sangmoo ; Kim, Jin Il ; Heo, Jun ; Lee, Ilseob ; Park, Sehee ; Hwang, Min Woong ; Bae, Joon Yong ; Park, Mee Sook ; Park, Hyoung Jin ; Park, Man-Seong. / The anti-influenza virus effect of Phellinus igniarius extract. In: Journal of Microbiology. 2013 ; Vol. 51, No. 5. pp. 676-681.
@article{8d1126aa612b4cb3b15f5964f6aee145,
title = "The anti-influenza virus effect of Phellinus igniarius extract",
abstract = "Herbal medicine has been used in the orient for thousands of years to treat large and small ailments, including microbial infections. Although there are treatments for influenza virus infection, there is no treatment for drug-resistant viruses. It is time that we explored and exploited the multi-component nature of herbal extracts as multi-drug combination therapies. Here, we present data on the anti-influenza virus effect of a medicinal mushroom, Phellinus igniarius. The P. igniarius water extract was effective against influenza A and B viruses, including 2009 pandemic H1N1, human H3N2, avian H9N2, and oseltamivir-resistant H1N1 viruses. Virological assays revealed that the extract may interfere with one or more early events in the influenza virus replication cycle, including viral attachment to the target cell. Therefore, our results provide new insights into the use of P. igniarius as an anti-influenza medicine.",
keywords = "antiviral, herbal, influenza, multi-drug, Phellinus igniarius",
author = "Sangmoo Lee and Kim, {Jin Il} and Jun Heo and Ilseob Lee and Sehee Park and Hwang, {Min Woong} and Bae, {Joon Yong} and Park, {Mee Sook} and Park, {Hyoung Jin} and Man-Seong Park",
year = "2013",
month = "10",
day = "1",
doi = "10.1007/s12275-013-3384-2",
language = "English",
volume = "51",
pages = "676--681",
journal = "Journal of Microbiology",
issn = "1225-8873",
publisher = "Microbiological Society of Korea",
number = "5",

}

TY - JOUR

T1 - The anti-influenza virus effect of Phellinus igniarius extract

AU - Lee, Sangmoo

AU - Kim, Jin Il

AU - Heo, Jun

AU - Lee, Ilseob

AU - Park, Sehee

AU - Hwang, Min Woong

AU - Bae, Joon Yong

AU - Park, Mee Sook

AU - Park, Hyoung Jin

AU - Park, Man-Seong

PY - 2013/10/1

Y1 - 2013/10/1

N2 - Herbal medicine has been used in the orient for thousands of years to treat large and small ailments, including microbial infections. Although there are treatments for influenza virus infection, there is no treatment for drug-resistant viruses. It is time that we explored and exploited the multi-component nature of herbal extracts as multi-drug combination therapies. Here, we present data on the anti-influenza virus effect of a medicinal mushroom, Phellinus igniarius. The P. igniarius water extract was effective against influenza A and B viruses, including 2009 pandemic H1N1, human H3N2, avian H9N2, and oseltamivir-resistant H1N1 viruses. Virological assays revealed that the extract may interfere with one or more early events in the influenza virus replication cycle, including viral attachment to the target cell. Therefore, our results provide new insights into the use of P. igniarius as an anti-influenza medicine.

AB - Herbal medicine has been used in the orient for thousands of years to treat large and small ailments, including microbial infections. Although there are treatments for influenza virus infection, there is no treatment for drug-resistant viruses. It is time that we explored and exploited the multi-component nature of herbal extracts as multi-drug combination therapies. Here, we present data on the anti-influenza virus effect of a medicinal mushroom, Phellinus igniarius. The P. igniarius water extract was effective against influenza A and B viruses, including 2009 pandemic H1N1, human H3N2, avian H9N2, and oseltamivir-resistant H1N1 viruses. Virological assays revealed that the extract may interfere with one or more early events in the influenza virus replication cycle, including viral attachment to the target cell. Therefore, our results provide new insights into the use of P. igniarius as an anti-influenza medicine.

KW - antiviral

KW - herbal

KW - influenza

KW - multi-drug

KW - Phellinus igniarius

UR - http://www.scopus.com/inward/record.url?scp=84887884348&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84887884348&partnerID=8YFLogxK

U2 - 10.1007/s12275-013-3384-2

DO - 10.1007/s12275-013-3384-2

M3 - Article

C2 - 24173646

AN - SCOPUS:84887884348

VL - 51

SP - 676

EP - 681

JO - Journal of Microbiology

JF - Journal of Microbiology

SN - 1225-8873

IS - 5

ER -