The antibacterial effect of fatty acids on Helicobacter pylori infection

Sung Woo Jung, Sang Woo Lee

    Research output: Contribution to journalReview articlepeer-review

    15 Citations (Scopus)


    Eradication of Helicobacter pylori is recommended for the management of various gastric diseases, including peptic ulcers and mucosa-associated lymphoid tissue lymphoma. Because of the increasing prevalence of antibiotic resistance, the eradication rates of antibiotic-based therapies have decreased. Therefore, alternative treatments should be considered. The antibacterial properties of fatty acids (FAs) have been investigated in various organisms, including H. pylori. Some FAs, particularly polyunsaturated FAs, have been shown to have bactericidal activity against H. pylori in vitro; however, their antibacterial effects in vivo remain controversial. Poor solubility and delivery of FAs may be important reasons for this discrepancy. Recently, a series of studies demonstrated the antibacterial effects of a liposomal formulation of linolenic acid against H. pylori, both in vitro and in vivo. Further research is needed to improve the bioavailability of FAs and apply them in clinical use.

    Original languageEnglish
    Pages (from-to)30-35
    Number of pages6
    JournalKorean Journal of Internal Medicine
    Issue number1
    Publication statusPublished - 2016 Jan


    • Anti-bacterial agents
    • Drug delivery systems
    • Fatty acids
    • Helicobacter pylori
    • Liposomes

    ASJC Scopus subject areas

    • Internal Medicine


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