The antibacterial effect of fatty acids on Helicobacter pylori infection

Sung Woo Jung, Sang Woo Lee

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Eradication of Helicobacter pylori is recommended for the management of various gastric diseases, including peptic ulcers and mucosa-associated lymphoid tissue lymphoma. Because of the increasing prevalence of antibiotic resistance, the eradication rates of antibiotic-based therapies have decreased. Therefore, alternative treatments should be considered. The antibacterial properties of fatty acids (FAs) have been investigated in various organisms, including H. pylori. Some FAs, particularly polyunsaturated FAs, have been shown to have bactericidal activity against H. pylori in vitro; however, their antibacterial effects in vivo remain controversial. Poor solubility and delivery of FAs may be important reasons for this discrepancy. Recently, a series of studies demonstrated the antibacterial effects of a liposomal formulation of linolenic acid against H. pylori, both in vitro and in vivo. Further research is needed to improve the bioavailability of FAs and apply them in clinical use.

Original languageEnglish
Pages (from-to)30-35
Number of pages6
JournalKorean Journal of Internal Medicine
Volume31
Issue number1
DOIs
Publication statusPublished - 2016 Jan

Keywords

  • Anti-bacterial agents
  • Drug delivery systems
  • Fatty acids
  • Helicobacter pylori
  • Liposomes

ASJC Scopus subject areas

  • Internal Medicine

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