The association between asthma and invasive pneumococcal disease: A nationwide study in Korea

Byung Ok Kwak, Ji-Tae Choung, Yong Mean Park

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The purpose of this study was to investigate the association between asthma and invasivepneumococcal disease (IPD) in Korea. A retrospective population-based cohort study wasconducted using the Korean Health Insurance Review and Assessment database 2010-2011.The subjects included 935,106 (2010) and 952,295 (2011), of whom 398 (2010) and 428(2011) patients with IPD were identified. There was significant difference in the prevalenceof IPD in patients with and without asthma (0.07% vs. 0.02% in 2010 and 0.08% vs.0.01% in 2011; P < 0.001). After adjusting for age and gender, patients with asthmashowed over a three-fold increased risk of IPD compared with patients without asthma(adjusted odds ratio [aOR] 3.90, 95% confidence interval [CI] 3.02-5.03 in 2010 / aOR,5.44; 95% CI, 4.10-7.22 in 2011; P < 0.001). These findings were also significant inchildren (aOR, 2.08; 95% CI, 1.25-3.45 in 2010; P = 0.005 / aOR, 3.26; 95% CI,1.74-6.11 in 2011; P < 0.001). Although diabetes mellitus was also significantly associatedwith IPD, relatively low ORs compared with those of asthma were noted (aOR, 1.85; 95%CI, 1.35-2.54 in 2010 / aOR, 2.40; 95% CI, 1.78-3.24 in 2011; P < 0.001). Both childrenand adults with asthma are at increased risk of developing IPD.

Original languageEnglish
Pages (from-to)60-65
Number of pages6
JournalJournal of Korean Medical Science
Volume30
Issue number1
DOIs
Publication statusPublished - 2015 Jan 1

Fingerprint

Korea
Asthma
Odds Ratio
Confidence Intervals
Health Insurance
Diabetes Mellitus
Cohort Studies
Databases
Population

Keywords

  • Asthma
  • Diabetes mellitus
  • Invasive pneumococcal disease

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The association between asthma and invasive pneumococcal disease : A nationwide study in Korea. / Kwak, Byung Ok; Choung, Ji-Tae; Park, Yong Mean.

In: Journal of Korean Medical Science, Vol. 30, No. 1, 01.01.2015, p. 60-65.

Research output: Contribution to journalArticle

@article{6733b734d42e4c3d9c8d9ae82bed5daa,
title = "The association between asthma and invasive pneumococcal disease: A nationwide study in Korea",
abstract = "The purpose of this study was to investigate the association between asthma and invasivepneumococcal disease (IPD) in Korea. A retrospective population-based cohort study wasconducted using the Korean Health Insurance Review and Assessment database 2010-2011.The subjects included 935,106 (2010) and 952,295 (2011), of whom 398 (2010) and 428(2011) patients with IPD were identified. There was significant difference in the prevalenceof IPD in patients with and without asthma (0.07{\%} vs. 0.02{\%} in 2010 and 0.08{\%} vs.0.01{\%} in 2011; P < 0.001). After adjusting for age and gender, patients with asthmashowed over a three-fold increased risk of IPD compared with patients without asthma(adjusted odds ratio [aOR] 3.90, 95{\%} confidence interval [CI] 3.02-5.03 in 2010 / aOR,5.44; 95{\%} CI, 4.10-7.22 in 2011; P < 0.001). These findings were also significant inchildren (aOR, 2.08; 95{\%} CI, 1.25-3.45 in 2010; P = 0.005 / aOR, 3.26; 95{\%} CI,1.74-6.11 in 2011; P < 0.001). Although diabetes mellitus was also significantly associatedwith IPD, relatively low ORs compared with those of asthma were noted (aOR, 1.85; 95{\%}CI, 1.35-2.54 in 2010 / aOR, 2.40; 95{\%} CI, 1.78-3.24 in 2011; P < 0.001). Both childrenand adults with asthma are at increased risk of developing IPD.",
keywords = "Asthma, Diabetes mellitus, Invasive pneumococcal disease",
author = "Kwak, {Byung Ok} and Ji-Tae Choung and Park, {Yong Mean}",
year = "2015",
month = "1",
day = "1",
doi = "10.3346/jkms.2015.30.1.60",
language = "English",
volume = "30",
pages = "60--65",
journal = "Journal of Korean Medical Science",
issn = "1011-8934",
publisher = "Korean Academy of Medical Science",
number = "1",

}

TY - JOUR

T1 - The association between asthma and invasive pneumococcal disease

T2 - A nationwide study in Korea

AU - Kwak, Byung Ok

AU - Choung, Ji-Tae

AU - Park, Yong Mean

PY - 2015/1/1

Y1 - 2015/1/1

N2 - The purpose of this study was to investigate the association between asthma and invasivepneumococcal disease (IPD) in Korea. A retrospective population-based cohort study wasconducted using the Korean Health Insurance Review and Assessment database 2010-2011.The subjects included 935,106 (2010) and 952,295 (2011), of whom 398 (2010) and 428(2011) patients with IPD were identified. There was significant difference in the prevalenceof IPD in patients with and without asthma (0.07% vs. 0.02% in 2010 and 0.08% vs.0.01% in 2011; P < 0.001). After adjusting for age and gender, patients with asthmashowed over a three-fold increased risk of IPD compared with patients without asthma(adjusted odds ratio [aOR] 3.90, 95% confidence interval [CI] 3.02-5.03 in 2010 / aOR,5.44; 95% CI, 4.10-7.22 in 2011; P < 0.001). These findings were also significant inchildren (aOR, 2.08; 95% CI, 1.25-3.45 in 2010; P = 0.005 / aOR, 3.26; 95% CI,1.74-6.11 in 2011; P < 0.001). Although diabetes mellitus was also significantly associatedwith IPD, relatively low ORs compared with those of asthma were noted (aOR, 1.85; 95%CI, 1.35-2.54 in 2010 / aOR, 2.40; 95% CI, 1.78-3.24 in 2011; P < 0.001). Both childrenand adults with asthma are at increased risk of developing IPD.

AB - The purpose of this study was to investigate the association between asthma and invasivepneumococcal disease (IPD) in Korea. A retrospective population-based cohort study wasconducted using the Korean Health Insurance Review and Assessment database 2010-2011.The subjects included 935,106 (2010) and 952,295 (2011), of whom 398 (2010) and 428(2011) patients with IPD were identified. There was significant difference in the prevalenceof IPD in patients with and without asthma (0.07% vs. 0.02% in 2010 and 0.08% vs.0.01% in 2011; P < 0.001). After adjusting for age and gender, patients with asthmashowed over a three-fold increased risk of IPD compared with patients without asthma(adjusted odds ratio [aOR] 3.90, 95% confidence interval [CI] 3.02-5.03 in 2010 / aOR,5.44; 95% CI, 4.10-7.22 in 2011; P < 0.001). These findings were also significant inchildren (aOR, 2.08; 95% CI, 1.25-3.45 in 2010; P = 0.005 / aOR, 3.26; 95% CI,1.74-6.11 in 2011; P < 0.001). Although diabetes mellitus was also significantly associatedwith IPD, relatively low ORs compared with those of asthma were noted (aOR, 1.85; 95%CI, 1.35-2.54 in 2010 / aOR, 2.40; 95% CI, 1.78-3.24 in 2011; P < 0.001). Both childrenand adults with asthma are at increased risk of developing IPD.

KW - Asthma

KW - Diabetes mellitus

KW - Invasive pneumococcal disease

UR - http://www.scopus.com/inward/record.url?scp=84951209394&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84951209394&partnerID=8YFLogxK

U2 - 10.3346/jkms.2015.30.1.60

DO - 10.3346/jkms.2015.30.1.60

M3 - Article

C2 - 25552884

AN - SCOPUS:84951209394

VL - 30

SP - 60

EP - 65

JO - Journal of Korean Medical Science

JF - Journal of Korean Medical Science

SN - 1011-8934

IS - 1

ER -