The association between hyperuricemia and the Trp64Arg polymorphism of the beta-3 adrenergic receptor

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Abstract

The object of this study was to determine the association of Trp64Arg polymorphism with hyperuricemia. This study is an age-matched, case-controlled study of 203 hyperuricemic and 203 normouricemic men. The frequency of genotypes was compared between the two groups. Possible confounding metabolic variables were included in a multiple logistic regression model for multivariate adjustment. The genotype frequencies of Trp64Trp, Trp64Arg, and Arg64Arg in hyperuricemic and normouricemic groups are respectively 130, 69, and 4 (64.0%, 34.0%, 2.0%) and 154, 45, and 4 (75.9%, 22.2%, 2.0%) (P = 0.029, Chi-square test). Simple logistic regression analysis indicated that the Trp64Arg genotype is significantly associated with hyperuricemia (OR = 1.816, 95% CI (1.167-2.827), P = 0.008). Multivariate analysis for controlling metabolic effects also showed a significant association with the occurrence of hyperuricemia (OR = 1.937, 95% CI (1.149-3.266), P = 0.013). Trp64Arg polymorphism of the beta-3 adrenergic receptor may be independently associated with hyperuricemia in males.

Original languageEnglish
Pages (from-to)835-839
Number of pages5
JournalRheumatology International
Volume27
Issue number9
DOIs
Publication statusPublished - 2007 Jul 1

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Adrenergic beta-3 Receptors
Hyperuricemia
Logistic Models
Genotype
Confounding Factors (Epidemiology)
Chi-Square Distribution
Multivariate Analysis
Regression Analysis

Keywords

  • Beta-3 adrenergic receptor
  • Gout
  • Hyperuricemia
  • Insulin Resistance
  • Polymorphism

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

Cite this

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title = "The association between hyperuricemia and the Trp64Arg polymorphism of the beta-3 adrenergic receptor",
abstract = "The object of this study was to determine the association of Trp64Arg polymorphism with hyperuricemia. This study is an age-matched, case-controlled study of 203 hyperuricemic and 203 normouricemic men. The frequency of genotypes was compared between the two groups. Possible confounding metabolic variables were included in a multiple logistic regression model for multivariate adjustment. The genotype frequencies of Trp64Trp, Trp64Arg, and Arg64Arg in hyperuricemic and normouricemic groups are respectively 130, 69, and 4 (64.0{\%}, 34.0{\%}, 2.0{\%}) and 154, 45, and 4 (75.9{\%}, 22.2{\%}, 2.0{\%}) (P = 0.029, Chi-square test). Simple logistic regression analysis indicated that the Trp64Arg genotype is significantly associated with hyperuricemia (OR = 1.816, 95{\%} CI (1.167-2.827), P = 0.008). Multivariate analysis for controlling metabolic effects also showed a significant association with the occurrence of hyperuricemia (OR = 1.937, 95{\%} CI (1.149-3.266), P = 0.013). Trp64Arg polymorphism of the beta-3 adrenergic receptor may be independently associated with hyperuricemia in males.",
keywords = "Beta-3 adrenergic receptor, Gout, Hyperuricemia, Insulin Resistance, Polymorphism",
author = "Rho, {Young Hee} and Sungjae Choi and Lee, {Young Ho} and Ji, {Jong Dae} and Song, {Gwan Gyu}",
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AU - Ji, Jong Dae

AU - Song, Gwan Gyu

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