The association between hyperuricemia and the Trp64Arg polymorphism of the beta-3 adrenergic receptor

Young Hee Rho, Seong Jae Choi, Young Ho Lee, Jong Dae Ji, Gwan Gyu Song

    Research output: Contribution to journalArticlepeer-review

    8 Citations (Scopus)

    Abstract

    The object of this study was to determine the association of Trp64Arg polymorphism with hyperuricemia. This study is an age-matched, case-controlled study of 203 hyperuricemic and 203 normouricemic men. The frequency of genotypes was compared between the two groups. Possible confounding metabolic variables were included in a multiple logistic regression model for multivariate adjustment. The genotype frequencies of Trp64Trp, Trp64Arg, and Arg64Arg in hyperuricemic and normouricemic groups are respectively 130, 69, and 4 (64.0%, 34.0%, 2.0%) and 154, 45, and 4 (75.9%, 22.2%, 2.0%) (P = 0.029, Chi-square test). Simple logistic regression analysis indicated that the Trp64Arg genotype is significantly associated with hyperuricemia (OR = 1.816, 95% CI (1.167-2.827), P = 0.008). Multivariate analysis for controlling metabolic effects also showed a significant association with the occurrence of hyperuricemia (OR = 1.937, 95% CI (1.149-3.266), P = 0.013). Trp64Arg polymorphism of the beta-3 adrenergic receptor may be independently associated with hyperuricemia in males.

    Original languageEnglish
    Pages (from-to)835-839
    Number of pages5
    JournalRheumatology International
    Volume27
    Issue number9
    DOIs
    Publication statusPublished - 2007 Jul

    Keywords

    • Beta-3 adrenergic receptor
    • Gout
    • Hyperuricemia
    • Insulin Resistance
    • Polymorphism

    ASJC Scopus subject areas

    • Rheumatology
    • Immunology and Allergy
    • Immunology

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