The association between irritable bowel syndrome and the coexistence of depression and insomnia

Seung Ku Lee, Dae Wui Yoon, Sunghee Lee, Jinkwan Kim, Kyung Mee Choi, Chol Shin

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective The individual occurrence of depression or insomnia is a risk factor for irritable bowel syndrome (IBS), but few researchers have evaluated the association between comorbid depression and insomnia and IBS. The aim of the present study is to explore the relationship between IBS and the coexistence of depression and insomnia in a Korean population-based cohort study. Methods A total of 3429 individuals who were enrolled in the Korean Genome and Epidemiology Study were analysed. Of the participants, 10.9% (n = 374) were diagnosed with IBS based on the Rome II criteria. Regarding depressive symptoms, subjects were sub-divided into three groups based on the Beck Depression Inventory (BDI) score. Insomnia was defined as a positive response to at least one of three questions on sleep states. Results The odds ratio (OR) of IBS increased proportionally as depressive symptoms worsened (OR: 1.64; 95% CI: 1.21–2.23 in middle tertile and OR: 2.61; 95% CI: 1.92–3.55 in highest tertile). Subjects with insomnia showed a higher OR of IBS than those without insomnia (OR: 1.81; 95% CI: 1.44–2.27). In the joint analysis of BDI and insomnia, the odds for IBS were significantly higher in all BDI tertiles with insomnia than in the corresponding BDI tertiles without insomnia. There was no significant interaction effect of BDI tertile or insomnia on IBS. Conclusion The presence of both depression and insomnia is significantly associated with IBS compared to each individual occurrence. Further prospective investigations are needed to explore possible causality between comorbid depression and insomnia and IBS.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalJournal of Psychosomatic Research
Volume93
DOIs
Publication statusPublished - 2017 Feb 1

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Irritable Bowel Syndrome
Sleep Initiation and Maintenance Disorders
Depression
Odds Ratio
Equipment and Supplies
Causality
Sleep
Epidemiology
Cohort Studies
Research Personnel
Genome

Keywords

  • Depression
  • Insomnia
  • Irritable bowel syndrome
  • Rome II

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health

Cite this

The association between irritable bowel syndrome and the coexistence of depression and insomnia. / Lee, Seung Ku; Yoon, Dae Wui; Lee, Sunghee; Kim, Jinkwan; Choi, Kyung Mee; Shin, Chol.

In: Journal of Psychosomatic Research, Vol. 93, 01.02.2017, p. 1-5.

Research output: Contribution to journalArticle

Lee, Seung Ku ; Yoon, Dae Wui ; Lee, Sunghee ; Kim, Jinkwan ; Choi, Kyung Mee ; Shin, Chol. / The association between irritable bowel syndrome and the coexistence of depression and insomnia. In: Journal of Psychosomatic Research. 2017 ; Vol. 93. pp. 1-5.
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N2 - Objective The individual occurrence of depression or insomnia is a risk factor for irritable bowel syndrome (IBS), but few researchers have evaluated the association between comorbid depression and insomnia and IBS. The aim of the present study is to explore the relationship between IBS and the coexistence of depression and insomnia in a Korean population-based cohort study. Methods A total of 3429 individuals who were enrolled in the Korean Genome and Epidemiology Study were analysed. Of the participants, 10.9% (n = 374) were diagnosed with IBS based on the Rome II criteria. Regarding depressive symptoms, subjects were sub-divided into three groups based on the Beck Depression Inventory (BDI) score. Insomnia was defined as a positive response to at least one of three questions on sleep states. Results The odds ratio (OR) of IBS increased proportionally as depressive symptoms worsened (OR: 1.64; 95% CI: 1.21–2.23 in middle tertile and OR: 2.61; 95% CI: 1.92–3.55 in highest tertile). Subjects with insomnia showed a higher OR of IBS than those without insomnia (OR: 1.81; 95% CI: 1.44–2.27). In the joint analysis of BDI and insomnia, the odds for IBS were significantly higher in all BDI tertiles with insomnia than in the corresponding BDI tertiles without insomnia. There was no significant interaction effect of BDI tertile or insomnia on IBS. Conclusion The presence of both depression and insomnia is significantly associated with IBS compared to each individual occurrence. Further prospective investigations are needed to explore possible causality between comorbid depression and insomnia and IBS.

AB - Objective The individual occurrence of depression or insomnia is a risk factor for irritable bowel syndrome (IBS), but few researchers have evaluated the association between comorbid depression and insomnia and IBS. The aim of the present study is to explore the relationship between IBS and the coexistence of depression and insomnia in a Korean population-based cohort study. Methods A total of 3429 individuals who were enrolled in the Korean Genome and Epidemiology Study were analysed. Of the participants, 10.9% (n = 374) were diagnosed with IBS based on the Rome II criteria. Regarding depressive symptoms, subjects were sub-divided into three groups based on the Beck Depression Inventory (BDI) score. Insomnia was defined as a positive response to at least one of three questions on sleep states. Results The odds ratio (OR) of IBS increased proportionally as depressive symptoms worsened (OR: 1.64; 95% CI: 1.21–2.23 in middle tertile and OR: 2.61; 95% CI: 1.92–3.55 in highest tertile). Subjects with insomnia showed a higher OR of IBS than those without insomnia (OR: 1.81; 95% CI: 1.44–2.27). In the joint analysis of BDI and insomnia, the odds for IBS were significantly higher in all BDI tertiles with insomnia than in the corresponding BDI tertiles without insomnia. There was no significant interaction effect of BDI tertile or insomnia on IBS. Conclusion The presence of both depression and insomnia is significantly associated with IBS compared to each individual occurrence. Further prospective investigations are needed to explore possible causality between comorbid depression and insomnia and IBS.

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