Suszeptibilität für inflammatorische Arthritis und miR-146a, miR-499 and IRAK1-Polymorphismen

Eine Metaanalyse

Translated title of the contribution: The association between susceptibility to inflammatory arthritis and miR-146a, miR-499 and IRAK1 polymorphisms: A meta-analysis

Gwan Gyu Song, S. C. Bae, Y. H. Seo, J. H. Kim, Sungjae Choi, Jong Dae Ji, Young Ho Lee

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objective: The aim of this study was to explore whether polymorphisms in miR-146a, miR-499 and IRAK1 are associated with susceptibility to inflammatory arthritis. Methods: Manual searches performed in the MEDLINE and EMBASE databases were used to identify published articles in which the roles of microRNA (miRNA) and IRAK1 polymorphisms in inflammatory arthritis were determined. A meta-analysis was conducted to investigate associations of the miR-146a rs2910164, miR-499 rs3746444, IRAK1 rs3027898and IRAK1 rs1059703 polymorphisms with susceptibility to inflammatory arthritis. Results: Nine studies containing 1224 patients and 1841 controls were included in the meta-analysis. The meta-analysis revealed no association between inflammatory arthritis and the rs2910164 C allele of miR-146a (odds ratio, OR = 0.974; 95 % confidence interval, CI = 0.810–1.091; p = 0.650). Stratification by ethnicity or disease type revealed no association between the miR-146a C allele and inflammatory arthritis in European, Middle Eastern or Asian patients with rheumatoid arthritis (RA) or juvenile idiopathic arthritis (JIA). However, the meta-analysis revealed an overall association between RA and the miR-499 rs374644 C (OR = 1.123, 95 % CI = 1.019–2.586, p = 0.041); stratification by ethnicity revealed a particular association in Middle Eastern populations (OR = 1.943, 95 % CI = 1.508–2.504, p = 2.7 × 10–8). The meta-analysis of IRAK1 polymorphisms revealed an association between inflammatory arthritis and the rs3027898CC genotype (OR = 2.602, 95 % CI = 1.387–4.879, p = 0.003). An analysis using the homozygote contrast showed the same pattern for the rs3027898CC genotype (OR = 2.472, 95 % CI = 1.300–4.700, p = 0.006). No association between inflammatory arthritis and the rs1059703 polymorphism was found. Conclusion: This meta-analysis suggests that the miR-499 rs374644 and IRAKI rs3027898 polymorphisms are associated with susceptibility to inflammatory arthritis.

Original languageGerman
Pages (from-to)637-645
Number of pages9
JournalZeitschrift fur Rheumatologie
Volume74
Issue number7
DOIs
Publication statusPublished - 2015 Sep 1

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Arthritis
Meta-Analysis
Rheumatoid Arthritis
Alleles
Genotype
Juvenile Arthritis
Homozygote
MicroRNAs
MEDLINE
Odds Ratio
Databases
Confidence Intervals
Population

Keywords

  • Ethnicity
  • Genotype
  • MEDLINE
  • MicroRNA
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Rheumatology

Cite this

Suszeptibilität für inflammatorische Arthritis und miR-146a, miR-499 and IRAK1-Polymorphismen : Eine Metaanalyse. / Song, Gwan Gyu; Bae, S. C.; Seo, Y. H.; Kim, J. H.; Choi, Sungjae; Ji, Jong Dae; Lee, Young Ho.

In: Zeitschrift fur Rheumatologie, Vol. 74, No. 7, 01.09.2015, p. 637-645.

Research output: Contribution to journalArticle

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title = "Suszeptibilit{\"a}t f{\"u}r inflammatorische Arthritis und miR-146a, miR-499 and IRAK1-Polymorphismen: Eine Metaanalyse",
abstract = "Objective: The aim of this study was to explore whether polymorphisms in miR-146a, miR-499 and IRAK1 are associated with susceptibility to inflammatory arthritis. Methods: Manual searches performed in the MEDLINE and EMBASE databases were used to identify published articles in which the roles of microRNA (miRNA) and IRAK1 polymorphisms in inflammatory arthritis were determined. A meta-analysis was conducted to investigate associations of the miR-146a rs2910164, miR-499 rs3746444, IRAK1 rs3027898and IRAK1 rs1059703 polymorphisms with susceptibility to inflammatory arthritis. Results: Nine studies containing 1224 patients and 1841 controls were included in the meta-analysis. The meta-analysis revealed no association between inflammatory arthritis and the rs2910164 C allele of miR-146a (odds ratio, OR = 0.974; 95 {\%} confidence interval, CI = 0.810–1.091; p = 0.650). Stratification by ethnicity or disease type revealed no association between the miR-146a C allele and inflammatory arthritis in European, Middle Eastern or Asian patients with rheumatoid arthritis (RA) or juvenile idiopathic arthritis (JIA). However, the meta-analysis revealed an overall association between RA and the miR-499 rs374644 C (OR = 1.123, 95 {\%} CI = 1.019–2.586, p = 0.041); stratification by ethnicity revealed a particular association in Middle Eastern populations (OR = 1.943, 95 {\%} CI = 1.508–2.504, p = 2.7 × 10–8). The meta-analysis of IRAK1 polymorphisms revealed an association between inflammatory arthritis and the rs3027898CC genotype (OR = 2.602, 95 {\%} CI = 1.387–4.879, p = 0.003). An analysis using the homozygote contrast showed the same pattern for the rs3027898CC genotype (OR = 2.472, 95 {\%} CI = 1.300–4.700, p = 0.006). No association between inflammatory arthritis and the rs1059703 polymorphism was found. Conclusion: This meta-analysis suggests that the miR-499 rs374644 and IRAKI rs3027898 polymorphisms are associated with susceptibility to inflammatory arthritis.",
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T1 - Suszeptibilität für inflammatorische Arthritis und miR-146a, miR-499 and IRAK1-Polymorphismen

T2 - Eine Metaanalyse

AU - Song, Gwan Gyu

AU - Bae, S. C.

AU - Seo, Y. H.

AU - Kim, J. H.

AU - Choi, Sungjae

AU - Ji, Jong Dae

AU - Lee, Young Ho

PY - 2015/9/1

Y1 - 2015/9/1

N2 - Objective: The aim of this study was to explore whether polymorphisms in miR-146a, miR-499 and IRAK1 are associated with susceptibility to inflammatory arthritis. Methods: Manual searches performed in the MEDLINE and EMBASE databases were used to identify published articles in which the roles of microRNA (miRNA) and IRAK1 polymorphisms in inflammatory arthritis were determined. A meta-analysis was conducted to investigate associations of the miR-146a rs2910164, miR-499 rs3746444, IRAK1 rs3027898and IRAK1 rs1059703 polymorphisms with susceptibility to inflammatory arthritis. Results: Nine studies containing 1224 patients and 1841 controls were included in the meta-analysis. The meta-analysis revealed no association between inflammatory arthritis and the rs2910164 C allele of miR-146a (odds ratio, OR = 0.974; 95 % confidence interval, CI = 0.810–1.091; p = 0.650). Stratification by ethnicity or disease type revealed no association between the miR-146a C allele and inflammatory arthritis in European, Middle Eastern or Asian patients with rheumatoid arthritis (RA) or juvenile idiopathic arthritis (JIA). However, the meta-analysis revealed an overall association between RA and the miR-499 rs374644 C (OR = 1.123, 95 % CI = 1.019–2.586, p = 0.041); stratification by ethnicity revealed a particular association in Middle Eastern populations (OR = 1.943, 95 % CI = 1.508–2.504, p = 2.7 × 10–8). The meta-analysis of IRAK1 polymorphisms revealed an association between inflammatory arthritis and the rs3027898CC genotype (OR = 2.602, 95 % CI = 1.387–4.879, p = 0.003). An analysis using the homozygote contrast showed the same pattern for the rs3027898CC genotype (OR = 2.472, 95 % CI = 1.300–4.700, p = 0.006). No association between inflammatory arthritis and the rs1059703 polymorphism was found. Conclusion: This meta-analysis suggests that the miR-499 rs374644 and IRAKI rs3027898 polymorphisms are associated with susceptibility to inflammatory arthritis.

AB - Objective: The aim of this study was to explore whether polymorphisms in miR-146a, miR-499 and IRAK1 are associated with susceptibility to inflammatory arthritis. Methods: Manual searches performed in the MEDLINE and EMBASE databases were used to identify published articles in which the roles of microRNA (miRNA) and IRAK1 polymorphisms in inflammatory arthritis were determined. A meta-analysis was conducted to investigate associations of the miR-146a rs2910164, miR-499 rs3746444, IRAK1 rs3027898and IRAK1 rs1059703 polymorphisms with susceptibility to inflammatory arthritis. Results: Nine studies containing 1224 patients and 1841 controls were included in the meta-analysis. The meta-analysis revealed no association between inflammatory arthritis and the rs2910164 C allele of miR-146a (odds ratio, OR = 0.974; 95 % confidence interval, CI = 0.810–1.091; p = 0.650). Stratification by ethnicity or disease type revealed no association between the miR-146a C allele and inflammatory arthritis in European, Middle Eastern or Asian patients with rheumatoid arthritis (RA) or juvenile idiopathic arthritis (JIA). However, the meta-analysis revealed an overall association between RA and the miR-499 rs374644 C (OR = 1.123, 95 % CI = 1.019–2.586, p = 0.041); stratification by ethnicity revealed a particular association in Middle Eastern populations (OR = 1.943, 95 % CI = 1.508–2.504, p = 2.7 × 10–8). The meta-analysis of IRAK1 polymorphisms revealed an association between inflammatory arthritis and the rs3027898CC genotype (OR = 2.602, 95 % CI = 1.387–4.879, p = 0.003). An analysis using the homozygote contrast showed the same pattern for the rs3027898CC genotype (OR = 2.472, 95 % CI = 1.300–4.700, p = 0.006). No association between inflammatory arthritis and the rs1059703 polymorphism was found. Conclusion: This meta-analysis suggests that the miR-499 rs374644 and IRAKI rs3027898 polymorphisms are associated with susceptibility to inflammatory arthritis.

KW - Ethnicity

KW - Genotype

KW - MEDLINE

KW - MicroRNA

KW - Rheumatoid arthritis

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