The association between the functional PTPN22 1858 C/T and MIF 2173 C/G polymorphisms and juvenile idiopathic arthritis: A meta-analysis

Young Ho Lee, Sang Cheol Bae, Gwan Gyu Song

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Abstract

Background The aim of this study was to determine whether the protein tyrosine phosphatase nonreceptor 22 (PTPN22) 1858 C/T (rs2476601) and macrophage migration inhibitory factor (MIF) -173 C/G polymorphisms confer susceptibility to juvenile idiopathic arthritis (JIA). Methods A meta-analysis was conducted on variant alleles versus common alleles of the PTPN22 1858 C/T and MIF -173 C/G polymorphisms across ten comparative studies, which containing 4,238 JIA patients and 6,012 normal control subjects. Results Ten comparative studies, consisting of nine European, and one Turkish population, were included in his meta-analysis. Meta-analysis showed an association between the T allele of the PTPN22 1858 C/T polymorphism and JIA in Europeans [odds ratio (OR) 1.311, 95% confidence interval (CI) 1.205-1.427, P\1 9 10-8]. In addition, meta-analysis revealed an association between the C allele of the MIF -173 C/G polymorphism and JIA in all subjects (OR 1.482, 95%CI 1.202-1.828, P = 2.3 9 10-4). Conclusions This meta-analysis confirms that the PTPN22 1858 C/T polymorphism is associated with JIA susceptibility in Europeans and shows that the MIF -173 C/G polymorphism may be associated with susceptibility to JIA. copyright

Original languageEnglish
Pages (from-to)411-415
Number of pages5
JournalInflammation Research
Volume61
Issue number5
DOIs
Publication statusPublished - 2012 May 1

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Keywords

  • Juvenile idiopathic arthritis
  • Meta-analysis
  • Migration inhibitory factor
  • Polymorphism
  • Protein tyrosine phosphatase nonreceptor 22

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

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