The association between the functional PTPN22 1858 C/T and MIF 2173 C/G polymorphisms and juvenile idiopathic arthritis: A meta-analysis

Young Ho Lee, Sang Cheol Bae, Gwan Gyu Song

    Research output: Contribution to journalArticlepeer-review

    23 Citations (Scopus)

    Abstract

    Background The aim of this study was to determine whether the protein tyrosine phosphatase nonreceptor 22 (PTPN22) 1858 C/T (rs2476601) and macrophage migration inhibitory factor (MIF) -173 C/G polymorphisms confer susceptibility to juvenile idiopathic arthritis (JIA). Methods A meta-analysis was conducted on variant alleles versus common alleles of the PTPN22 1858 C/T and MIF -173 C/G polymorphisms across ten comparative studies, which containing 4,238 JIA patients and 6,012 normal control subjects. Results Ten comparative studies, consisting of nine European, and one Turkish population, were included in his meta-analysis. Meta-analysis showed an association between the T allele of the PTPN22 1858 C/T polymorphism and JIA in Europeans [odds ratio (OR) 1.311, 95% confidence interval (CI) 1.205-1.427, P\1 9 10-8]. In addition, meta-analysis revealed an association between the C allele of the MIF -173 C/G polymorphism and JIA in all subjects (OR 1.482, 95%CI 1.202-1.828, P = 2.3 9 10-4). Conclusions This meta-analysis confirms that the PTPN22 1858 C/T polymorphism is associated with JIA susceptibility in Europeans and shows that the MIF -173 C/G polymorphism may be associated with susceptibility to JIA. copyright

    Original languageEnglish
    Pages (from-to)411-415
    Number of pages5
    JournalInflammation Research
    Volume61
    Issue number5
    DOIs
    Publication statusPublished - 2012 May

    Keywords

    • Juvenile idiopathic arthritis
    • Meta-analysis
    • Migration inhibitory factor
    • Polymorphism
    • Protein tyrosine phosphatase nonreceptor 22

    ASJC Scopus subject areas

    • Immunology
    • Pharmacology

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