The association between the mannose-binding lectin codon 54 polymorphism and systemic lupus erythematosus: A meta-analysis update

Young Ho Lee, Hye Soon Lee, Sung Jae Choi, Jong Dae Ji, Gwan Gyu Song

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    9 Citations (Scopus)

    Abstract

    The aim of this study was to determine whether the functional mannose-binding lectin (MBL2) exon 1 codon 54 polymorphism (rs1800450) confers susceptibility to systemic lupus erythematosus (SLE) in ethnically different populations. A meta-analysis was conducted on the MBL2 codon 54 polymorphism across 21 comparative studies. Meta-analysis showed an association between the MBL2 codon 54 B allele and SLE in all study subjects [odds ratio (OR) = 1.298, 95% confidence interval (CI) = 1.154-1.459, P = 1.4 9 10-5]. Analysis after stratification by ethnicity indicated that the MBL2 codon 54 B allele is significantly associated with SLE in Europeans, Asian, and Africans (OR = 1.246, 95% CI = 1.062-1.462, P = 0.007; OR = 1.268, 95% CI = 1.049-1.532, P = 0.014; OR = 1.939, 95% CI = 1.269-2.962, P = 0.002, respectively). However, African Americans had a much lower prevalence of the T allele (5.8%) than any other populations studied, whereas Asians had the highest prevalence (16.2%). This meta-analysis confirms that the MBL2 codon 54 polymorphism is associated with SLE susceptibility in different ethnic groups, and that its prevalence is ethnicity dependent.

    Original languageEnglish
    Pages (from-to)5569-5574
    Number of pages6
    JournalMolecular biology reports
    Volume39
    Issue number5
    DOIs
    Publication statusPublished - 2012 May

    Keywords

    • Mannose-binding lectin
    • Meta-analysis
    • Polymorphism
    • Systemic lupus erythematosus

    ASJC Scopus subject areas

    • Molecular Biology
    • Genetics

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