Abstract
The aim of this study was to determine whether the functional mannose-binding lectin (MBL2) exon 1 codon 54 polymorphism (rs1800450) confers susceptibility to systemic lupus erythematosus (SLE) in ethnically different populations. A meta-analysis was conducted on the MBL2 codon 54 polymorphism across 21 comparative studies. Meta-analysis showed an association between the MBL2 codon 54 B allele and SLE in all study subjects [odds ratio (OR) = 1.298, 95% confidence interval (CI) = 1.154-1.459, P = 1.4 9 10-5]. Analysis after stratification by ethnicity indicated that the MBL2 codon 54 B allele is significantly associated with SLE in Europeans, Asian, and Africans (OR = 1.246, 95% CI = 1.062-1.462, P = 0.007; OR = 1.268, 95% CI = 1.049-1.532, P = 0.014; OR = 1.939, 95% CI = 1.269-2.962, P = 0.002, respectively). However, African Americans had a much lower prevalence of the T allele (5.8%) than any other populations studied, whereas Asians had the highest prevalence (16.2%). This meta-analysis confirms that the MBL2 codon 54 polymorphism is associated with SLE susceptibility in different ethnic groups, and that its prevalence is ethnicity dependent.
| Original language | English |
|---|---|
| Pages (from-to) | 5569-5574 |
| Number of pages | 6 |
| Journal | Molecular Biology Reports |
| Volume | 39 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2012 May 1 |
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Keywords
- Mannose-binding lectin
- Meta-analysis
- Polymorphism
- Systemic lupus erythematosus
ASJC Scopus subject areas
- Molecular Biology
- Genetics
Cite this
The association between the mannose-binding lectin codon 54 polymorphism and systemic lupus erythematosus : A meta-analysis update. / Lee, Young Ho; Lee, Hye Soon; Choi, Sungjae; Ji, Jong Dae; Song, Gwan Gyu.
In: Molecular Biology Reports, Vol. 39, No. 5, 01.05.2012, p. 5569-5574.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The association between the mannose-binding lectin codon 54 polymorphism and systemic lupus erythematosus
T2 - A meta-analysis update
AU - Lee, Young Ho
AU - Lee, Hye Soon
AU - Choi, Sungjae
AU - Ji, Jong Dae
AU - Song, Gwan Gyu
PY - 2012/5/1
Y1 - 2012/5/1
N2 - The aim of this study was to determine whether the functional mannose-binding lectin (MBL2) exon 1 codon 54 polymorphism (rs1800450) confers susceptibility to systemic lupus erythematosus (SLE) in ethnically different populations. A meta-analysis was conducted on the MBL2 codon 54 polymorphism across 21 comparative studies. Meta-analysis showed an association between the MBL2 codon 54 B allele and SLE in all study subjects [odds ratio (OR) = 1.298, 95% confidence interval (CI) = 1.154-1.459, P = 1.4 9 10-5]. Analysis after stratification by ethnicity indicated that the MBL2 codon 54 B allele is significantly associated with SLE in Europeans, Asian, and Africans (OR = 1.246, 95% CI = 1.062-1.462, P = 0.007; OR = 1.268, 95% CI = 1.049-1.532, P = 0.014; OR = 1.939, 95% CI = 1.269-2.962, P = 0.002, respectively). However, African Americans had a much lower prevalence of the T allele (5.8%) than any other populations studied, whereas Asians had the highest prevalence (16.2%). This meta-analysis confirms that the MBL2 codon 54 polymorphism is associated with SLE susceptibility in different ethnic groups, and that its prevalence is ethnicity dependent.
AB - The aim of this study was to determine whether the functional mannose-binding lectin (MBL2) exon 1 codon 54 polymorphism (rs1800450) confers susceptibility to systemic lupus erythematosus (SLE) in ethnically different populations. A meta-analysis was conducted on the MBL2 codon 54 polymorphism across 21 comparative studies. Meta-analysis showed an association between the MBL2 codon 54 B allele and SLE in all study subjects [odds ratio (OR) = 1.298, 95% confidence interval (CI) = 1.154-1.459, P = 1.4 9 10-5]. Analysis after stratification by ethnicity indicated that the MBL2 codon 54 B allele is significantly associated with SLE in Europeans, Asian, and Africans (OR = 1.246, 95% CI = 1.062-1.462, P = 0.007; OR = 1.268, 95% CI = 1.049-1.532, P = 0.014; OR = 1.939, 95% CI = 1.269-2.962, P = 0.002, respectively). However, African Americans had a much lower prevalence of the T allele (5.8%) than any other populations studied, whereas Asians had the highest prevalence (16.2%). This meta-analysis confirms that the MBL2 codon 54 polymorphism is associated with SLE susceptibility in different ethnic groups, and that its prevalence is ethnicity dependent.
KW - Mannose-binding lectin
KW - Meta-analysis
KW - Polymorphism
KW - Systemic lupus erythematosus
UR - http://www.scopus.com/inward/record.url?scp=84863762526&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84863762526&partnerID=8YFLogxK
U2 - 10.1007/s11033-011-1361-6
DO - 10.1007/s11033-011-1361-6
M3 - Article
C2 - 22183303
AN - SCOPUS:84863762526
VL - 39
SP - 5569
EP - 5574
JO - Molecular Biology Reports
JF - Molecular Biology Reports
SN - 0301-4851
IS - 5
ER -