The association between the PTPN22 C1858T polymorphism and rheumatoid arthritis: A meta-analysis update

Young Ho Lee, Sang Cheol Bae, Sung Jae Choi, Jong Dae Ji, Gwan Gyu Song

    Research output: Contribution to journalArticlepeer-review

    15 Citations (Scopus)

    Abstract

    The aim of this study was to determine whether the protein tyrosine phosphatase nonreceptor 22 (PTPN22) C1858T polymorphism confers susceptibility to rheumatoid arthritis (RA) in populations with different ethnicities. A meta-analysis was conducted on the PTPN22 C1858T polymorphism involving eighteen studies, which in total contained 20344 RA patients and 21828 controls. Metaanalysis revealed an association between the PTPN22 C1858T polymorphism T allele and RA in all subjects (odds ratio [OR] = 1.637, 95% confidence interval [CI] = 1.514-1.770, P<0.001). After stratification by ethnicity, analysis indicated that the PTPN22 C1858T polymorphism T allele was significantly associated with RA in Europeans and Non-Europeans (OR = 1.587, 95% CI = 1.486-1.696, P<0.001; OR = 1.748, 95% CI = 1.274-2.398, P< 0.001). Meta-analysis of the CT ? TT genotype showed the same result patterns as that shown by the PTPN22 C1858T polymorphism T allele. Furthermore, a direct comparison between rheumatoid factor (RF)-positive and -negative subjects revealed a significant association with the T allele in RA patients with RF, but not in subjects without RF. In conclusion, this meta-analysis confirms that the PTPN22 C1858T polymorphism is associated with RA susceptibility in different ethnic groups, especially in Europeans, and the PTPN22 C1858T polymorphism T allele is significantly more prevalent in RF-positive patents than in RF-negative patients.

    Original languageEnglish
    Pages (from-to)3453-3460
    Number of pages8
    JournalMolecular biology reports
    Volume39
    Issue number4
    DOIs
    Publication statusPublished - 2012 Apr

    Keywords

    • Meta-analysis
    • Polymorphism
    • Protein tyrosine phosphatase nonreceptor 22
    • Rheumatoid arthritis

    ASJC Scopus subject areas

    • Molecular Biology
    • Genetics

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