The association between the PTPN22 C1858T polymorphism and systemic lupus erythematosus

A meta-analysis update

W. W. Lea, Young Ho Lee

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The aim of this study was to determine whether the functional protein tyrosine phosphatase nonreceptor 22 (PTPN22) C1858T polymorphism (rs2476601) confers susceptibility to systemic lupus erythematosus (SLE) in ethnically different populations. A meta-analysis was conducted on the PTPN22 C1858T polymorphism across 11 comparative studies. Meta-analysis showed an association between the PTPN22 1858T allele and SLE in all study subjects (odds ratio (OR) 1.560, 95% confidence interval (CI) 1.336, 1.822, p = 2.0 × 10 -8). Analysis after stratification by ethnicity indicated that the PTPN22 1858T allele was significantly associated with SLE in Europeans and Hispanics (OR 1.490, 95% CI 1.280, 1.735, p = 2.0 × 10-8; OR 2.355, 95% CI 1.644, 3.373, p = 2.9 × 10-6). The meta-analysis showed that the C/T + T/T genotype was associated with susceptibility to SLE in all study subjects, Europeans, and Hispanics populations, and an association between the T/T genotype with SLE in Europeans. African Americans had a much lower prevalence of the T allele (2.2%) than any other population studied, and Europeans had the highest frequency (9.5%). In conclusion, this meta-analysis confirms that the PTPN22 C1858T polymorphism is associated with SLE susceptibility in different ethnic groups, and that its prevalence is ethnicity dependent. Lupus (2011) 20, 51-57.

Original languageEnglish
Pages (from-to)51-57
Number of pages7
JournalLupus
Volume20
Issue number1
DOIs
Publication statusPublished - 2011 Jan 1

Fingerprint

Protein Tyrosine Phosphatases
Systemic Lupus Erythematosus
Meta-Analysis
Alleles
Odds Ratio
Confidence Intervals
Hispanic Americans
Genotype
Population
Ethnic Groups
African Americans

Keywords

  • meta-analysis
  • polymorphism
  • protein tyrosine phosphatase nonreceptor 22
  • systemic lupus erythematosus

ASJC Scopus subject areas

  • Rheumatology

Cite this

The association between the PTPN22 C1858T polymorphism and systemic lupus erythematosus : A meta-analysis update. / Lea, W. W.; Lee, Young Ho.

In: Lupus, Vol. 20, No. 1, 01.01.2011, p. 51-57.

Research output: Contribution to journalArticle

@article{859efea5bcd5488e8ecc601960d87e8f,
title = "The association between the PTPN22 C1858T polymorphism and systemic lupus erythematosus: A meta-analysis update",
abstract = "The aim of this study was to determine whether the functional protein tyrosine phosphatase nonreceptor 22 (PTPN22) C1858T polymorphism (rs2476601) confers susceptibility to systemic lupus erythematosus (SLE) in ethnically different populations. A meta-analysis was conducted on the PTPN22 C1858T polymorphism across 11 comparative studies. Meta-analysis showed an association between the PTPN22 1858T allele and SLE in all study subjects (odds ratio (OR) 1.560, 95{\%} confidence interval (CI) 1.336, 1.822, p = 2.0 × 10 -8). Analysis after stratification by ethnicity indicated that the PTPN22 1858T allele was significantly associated with SLE in Europeans and Hispanics (OR 1.490, 95{\%} CI 1.280, 1.735, p = 2.0 × 10-8; OR 2.355, 95{\%} CI 1.644, 3.373, p = 2.9 × 10-6). The meta-analysis showed that the C/T + T/T genotype was associated with susceptibility to SLE in all study subjects, Europeans, and Hispanics populations, and an association between the T/T genotype with SLE in Europeans. African Americans had a much lower prevalence of the T allele (2.2{\%}) than any other population studied, and Europeans had the highest frequency (9.5{\%}). In conclusion, this meta-analysis confirms that the PTPN22 C1858T polymorphism is associated with SLE susceptibility in different ethnic groups, and that its prevalence is ethnicity dependent. Lupus (2011) 20, 51-57.",
keywords = "meta-analysis, polymorphism, protein tyrosine phosphatase nonreceptor 22, systemic lupus erythematosus",
author = "Lea, {W. W.} and Lee, {Young Ho}",
year = "2011",
month = "1",
day = "1",
doi = "10.1177/0961203310381774",
language = "English",
volume = "20",
pages = "51--57",
journal = "Lupus",
issn = "0961-2033",
publisher = "SAGE Publications Ltd",
number = "1",

}

TY - JOUR

T1 - The association between the PTPN22 C1858T polymorphism and systemic lupus erythematosus

T2 - A meta-analysis update

AU - Lea, W. W.

AU - Lee, Young Ho

PY - 2011/1/1

Y1 - 2011/1/1

N2 - The aim of this study was to determine whether the functional protein tyrosine phosphatase nonreceptor 22 (PTPN22) C1858T polymorphism (rs2476601) confers susceptibility to systemic lupus erythematosus (SLE) in ethnically different populations. A meta-analysis was conducted on the PTPN22 C1858T polymorphism across 11 comparative studies. Meta-analysis showed an association between the PTPN22 1858T allele and SLE in all study subjects (odds ratio (OR) 1.560, 95% confidence interval (CI) 1.336, 1.822, p = 2.0 × 10 -8). Analysis after stratification by ethnicity indicated that the PTPN22 1858T allele was significantly associated with SLE in Europeans and Hispanics (OR 1.490, 95% CI 1.280, 1.735, p = 2.0 × 10-8; OR 2.355, 95% CI 1.644, 3.373, p = 2.9 × 10-6). The meta-analysis showed that the C/T + T/T genotype was associated with susceptibility to SLE in all study subjects, Europeans, and Hispanics populations, and an association between the T/T genotype with SLE in Europeans. African Americans had a much lower prevalence of the T allele (2.2%) than any other population studied, and Europeans had the highest frequency (9.5%). In conclusion, this meta-analysis confirms that the PTPN22 C1858T polymorphism is associated with SLE susceptibility in different ethnic groups, and that its prevalence is ethnicity dependent. Lupus (2011) 20, 51-57.

AB - The aim of this study was to determine whether the functional protein tyrosine phosphatase nonreceptor 22 (PTPN22) C1858T polymorphism (rs2476601) confers susceptibility to systemic lupus erythematosus (SLE) in ethnically different populations. A meta-analysis was conducted on the PTPN22 C1858T polymorphism across 11 comparative studies. Meta-analysis showed an association between the PTPN22 1858T allele and SLE in all study subjects (odds ratio (OR) 1.560, 95% confidence interval (CI) 1.336, 1.822, p = 2.0 × 10 -8). Analysis after stratification by ethnicity indicated that the PTPN22 1858T allele was significantly associated with SLE in Europeans and Hispanics (OR 1.490, 95% CI 1.280, 1.735, p = 2.0 × 10-8; OR 2.355, 95% CI 1.644, 3.373, p = 2.9 × 10-6). The meta-analysis showed that the C/T + T/T genotype was associated with susceptibility to SLE in all study subjects, Europeans, and Hispanics populations, and an association between the T/T genotype with SLE in Europeans. African Americans had a much lower prevalence of the T allele (2.2%) than any other population studied, and Europeans had the highest frequency (9.5%). In conclusion, this meta-analysis confirms that the PTPN22 C1858T polymorphism is associated with SLE susceptibility in different ethnic groups, and that its prevalence is ethnicity dependent. Lupus (2011) 20, 51-57.

KW - meta-analysis

KW - polymorphism

KW - protein tyrosine phosphatase nonreceptor 22

KW - systemic lupus erythematosus

UR - http://www.scopus.com/inward/record.url?scp=78751497823&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78751497823&partnerID=8YFLogxK

U2 - 10.1177/0961203310381774

DO - 10.1177/0961203310381774

M3 - Article

VL - 20

SP - 51

EP - 57

JO - Lupus

JF - Lupus

SN - 0961-2033

IS - 1

ER -