The association of heavy metal of blood and serum in the Alzheimer's diseases

Ji Yeon Lee, Jae Hoon Kim, DalWoong Choi, Dong Woo Lee, Jun Hyun Park, Hye Jung Yoon, Hee Soo Pyo, Ho Jang Kwon, Kyung Su Park

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Abstract

This study has attempted to establish an analysis method through validation against heavy metals in thebody (Pb, Cd and Hg) using ICP-MS and Gold amalgamation and find out the relevance between heavy metal and Alzheimer's disease after analyzing the distribution of heavy metal concentration (Pb, Cd and Hg) and correlations between a control group and Alzheimer's disease group. In this study, Pb and Cd levels in the blood and serum were validation using ICP-MS. For analysis of Hg levels in the blood and serum, the gold amalgamation-based 'Direct Mercury Analyzer' has been used. According to an analysis on the heavy metal concentration (Pb, Cd and Hg concentration) in the blood, Cd concentration was high in the Alzheimer's disease group. In the serum, on the contrary, Pb and Hg were high in the Alzheimer's disease group. For analysis of correlations between heavy metal levels in the blood and serum and Alzheimer's disease, t-test has been performed. Even though correlations were observed between the blood lead levels and Alzheimer's disease, they were statistically insignificant because the concentration was higher in a control group. No significance was found in Cd and Hg. In the serum, on the other hand, no statistical significance was found between the heavy metal (Pb, Cd and Hg) and Alzheimer's disease. In this study, no statistical significance was observed between heavy metal and decrease in cognitive intelligence. However, it appears that a further study needs to be performed because the results of the conventional studies were inconsistent.

Original languageEnglish
Pages (from-to)93-98
Number of pages6
JournalToxicological Research
Volume28
Issue number2
DOIs
Publication statusPublished - 2012 Jun 1

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Keywords

  • Alzheimer's diseases
  • Association
  • Biomonitoring
  • Heavy metal

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Lee, J. Y., Kim, J. H., Choi, D., Lee, D. W., Park, J. H., Yoon, H. J., Pyo, H. S., Kwon, H. J., & Park, K. S. (2012). The association of heavy metal of blood and serum in the Alzheimer's diseases. Toxicological Research, 28(2), 93-98. https://doi.org/10.5487/TR.2012.28.2.093