The association of low muscle mass with soluble receptor for advanced glycation end products (sRAGE): The Korean Sarcopenic Obesity Study (KSOS)

Tae Nyun Kim, Man Sik Park, Eun Joo Lee, Hye Soo Chung, Hye-Jin Yoo, Hyun Joo Kang, Wook Song, Sei-Hyun Baik, Kyung Mook Choi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Advanced glycation end products (AGEs) are accumulated with aging in various tissues of humans. The soluble receptor for AGEs (sRAGE) exerts a protective role against the development of aging-related chronic disorders by neutralizing the action of AGEs. We investigated the implication of sRAGE on low muscle mass in Asian men and women. Methods: This cross-sectional study included a 390-participant, nondiabetic subcohort recruited within the framework of the Korean Sarcopenic Obesity Study, an ongoing prospective cohort study. Low muscle mass was defined based on the distribution of appendicular skeletal muscle mass divided by body mass index, as proposed by the Foundation for the National Institutes Sarcopenia Project. Results: Serum sRAGE levels were significantly lower in participants with low muscle mass than in participants without low muscle mass (0.76 [0.60-1.00] ng/mL vs 0.87 [0.67-1.15] ng/mL, P = .005). In age- and sex-adjusted correlation analyses, appendicular skeletal muscle mass divided by body mass index was associated with sRAGE (r = 0.109, P = .037). Furthermore, decreased circulating levels of sRAGE are independently associated with low muscle mass (odds ratio = 0.254, P = .002) after adjusting for confounding factors, including insulin resistance and inflammatory markers. Conclusions: The present study shows that a low circulating level of sRAGE may be an independent risk factor for the presence of low muscle mass.

Original languageEnglish
JournalDiabetes/Metabolism Research and Reviews
DOIs
Publication statusAccepted/In press - 2018 Jan 1

Keywords

  • Body composition
  • Low muscle mass
  • Sarcopenia
  • sRAGE

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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