The associations between interleukin-1 polymorphisms and susceptibility to ankylosing spondylitis: A meta-analysis

Wu in Lea, Young Ho Lee

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Objective: The aim of this study was to determine whether polymorphisms of interleukin-1 (IL-1) confer susceptibility to ankylosing spondylitis (AS). Methods: The authors conducted meta-analyses on associations between IL-1 polymorphisms and AS susceptibility, using fixed or random effects models. In order to avoid duplications and data previously subjected to meta-analysis, we performed meta-analysis on studies if new data on IL-1 polymorphisms in AS were reported. Results: A total of nine studies consisting of 20 separate comparisons of association between IL-1 polymorphisms and AS susceptibility were included in this meta-analysis. These were performed on European, Asian, and Latin American population samples. Meta-analysis revealed a significant association between the 2 allele of the IL-1F10.3 polymorphism (rs3811581) and the risk of developing AS in Europeans (OR = 0.775, 95% CI = 0.605-0.992, P=0.043). Furthermore, the OR of the 2 allele of IL-1A+889 (rs1800587) was found to be significantly increased in Europeans with AS (OR = 1.357, 95% CI = 1.085-1.697, P=0.007). However, meta-analyses of the IL-1B-511, IL-1B+3953, and ILF7.1 polymorphisms and of the variable numbers of tandem repeats of the IL-1 receptor antagonist gene (IL-1RN VNTR) revealed no association between AS and these polymorphisms. Conclusions: In addition to the three known IL-1 polymorphisms, rs2856836, rs17561, and rs1894399, found in previous meta-analysis, this meta-analysis shows that the IL-1F10.3 and IL-1A+889 polymorphisms are associated with the development of AS in Europeans but not in Asians.

Original languageEnglish
Pages (from-to)370-374
Number of pages5
JournalJoint Bone Spine
Volume79
Issue number4
DOIs
Publication statusPublished - 2012 Jul 1

Fingerprint

Ankylosing Spondylitis
Interleukin-1
Meta-Analysis
Interleukin-2
Alleles
Minisatellite Repeats
Interleukin-1 Receptors
Asian Americans
Population
Genes

Keywords

  • Ankylosing spondylitis
  • Interleukin-1
  • Meta-analysis
  • Polymorphism

ASJC Scopus subject areas

  • Rheumatology

Cite this

The associations between interleukin-1 polymorphisms and susceptibility to ankylosing spondylitis : A meta-analysis. / Lea, Wu in; Lee, Young Ho.

In: Joint Bone Spine, Vol. 79, No. 4, 01.07.2012, p. 370-374.

Research output: Contribution to journalArticle

@article{1d72a5b68c774fb8b06225aa545f9ce2,
title = "The associations between interleukin-1 polymorphisms and susceptibility to ankylosing spondylitis: A meta-analysis",
abstract = "Objective: The aim of this study was to determine whether polymorphisms of interleukin-1 (IL-1) confer susceptibility to ankylosing spondylitis (AS). Methods: The authors conducted meta-analyses on associations between IL-1 polymorphisms and AS susceptibility, using fixed or random effects models. In order to avoid duplications and data previously subjected to meta-analysis, we performed meta-analysis on studies if new data on IL-1 polymorphisms in AS were reported. Results: A total of nine studies consisting of 20 separate comparisons of association between IL-1 polymorphisms and AS susceptibility were included in this meta-analysis. These were performed on European, Asian, and Latin American population samples. Meta-analysis revealed a significant association between the 2 allele of the IL-1F10.3 polymorphism (rs3811581) and the risk of developing AS in Europeans (OR = 0.775, 95{\%} CI = 0.605-0.992, P=0.043). Furthermore, the OR of the 2 allele of IL-1A+889 (rs1800587) was found to be significantly increased in Europeans with AS (OR = 1.357, 95{\%} CI = 1.085-1.697, P=0.007). However, meta-analyses of the IL-1B-511, IL-1B+3953, and ILF7.1 polymorphisms and of the variable numbers of tandem repeats of the IL-1 receptor antagonist gene (IL-1RN VNTR) revealed no association between AS and these polymorphisms. Conclusions: In addition to the three known IL-1 polymorphisms, rs2856836, rs17561, and rs1894399, found in previous meta-analysis, this meta-analysis shows that the IL-1F10.3 and IL-1A+889 polymorphisms are associated with the development of AS in Europeans but not in Asians.",
keywords = "Ankylosing spondylitis, Interleukin-1, Meta-analysis, Polymorphism",
author = "Lea, {Wu in} and Lee, {Young Ho}",
year = "2012",
month = "7",
day = "1",
doi = "10.1016/j.jbspin.2011.06.010",
language = "English",
volume = "79",
pages = "370--374",
journal = "Revue du Rhumatisme (English Edition)",
issn = "1169-8446",
publisher = "Elsevier Masson",
number = "4",

}

TY - JOUR

T1 - The associations between interleukin-1 polymorphisms and susceptibility to ankylosing spondylitis

T2 - A meta-analysis

AU - Lea, Wu in

AU - Lee, Young Ho

PY - 2012/7/1

Y1 - 2012/7/1

N2 - Objective: The aim of this study was to determine whether polymorphisms of interleukin-1 (IL-1) confer susceptibility to ankylosing spondylitis (AS). Methods: The authors conducted meta-analyses on associations between IL-1 polymorphisms and AS susceptibility, using fixed or random effects models. In order to avoid duplications and data previously subjected to meta-analysis, we performed meta-analysis on studies if new data on IL-1 polymorphisms in AS were reported. Results: A total of nine studies consisting of 20 separate comparisons of association between IL-1 polymorphisms and AS susceptibility were included in this meta-analysis. These were performed on European, Asian, and Latin American population samples. Meta-analysis revealed a significant association between the 2 allele of the IL-1F10.3 polymorphism (rs3811581) and the risk of developing AS in Europeans (OR = 0.775, 95% CI = 0.605-0.992, P=0.043). Furthermore, the OR of the 2 allele of IL-1A+889 (rs1800587) was found to be significantly increased in Europeans with AS (OR = 1.357, 95% CI = 1.085-1.697, P=0.007). However, meta-analyses of the IL-1B-511, IL-1B+3953, and ILF7.1 polymorphisms and of the variable numbers of tandem repeats of the IL-1 receptor antagonist gene (IL-1RN VNTR) revealed no association between AS and these polymorphisms. Conclusions: In addition to the three known IL-1 polymorphisms, rs2856836, rs17561, and rs1894399, found in previous meta-analysis, this meta-analysis shows that the IL-1F10.3 and IL-1A+889 polymorphisms are associated with the development of AS in Europeans but not in Asians.

AB - Objective: The aim of this study was to determine whether polymorphisms of interleukin-1 (IL-1) confer susceptibility to ankylosing spondylitis (AS). Methods: The authors conducted meta-analyses on associations between IL-1 polymorphisms and AS susceptibility, using fixed or random effects models. In order to avoid duplications and data previously subjected to meta-analysis, we performed meta-analysis on studies if new data on IL-1 polymorphisms in AS were reported. Results: A total of nine studies consisting of 20 separate comparisons of association between IL-1 polymorphisms and AS susceptibility were included in this meta-analysis. These were performed on European, Asian, and Latin American population samples. Meta-analysis revealed a significant association between the 2 allele of the IL-1F10.3 polymorphism (rs3811581) and the risk of developing AS in Europeans (OR = 0.775, 95% CI = 0.605-0.992, P=0.043). Furthermore, the OR of the 2 allele of IL-1A+889 (rs1800587) was found to be significantly increased in Europeans with AS (OR = 1.357, 95% CI = 1.085-1.697, P=0.007). However, meta-analyses of the IL-1B-511, IL-1B+3953, and ILF7.1 polymorphisms and of the variable numbers of tandem repeats of the IL-1 receptor antagonist gene (IL-1RN VNTR) revealed no association between AS and these polymorphisms. Conclusions: In addition to the three known IL-1 polymorphisms, rs2856836, rs17561, and rs1894399, found in previous meta-analysis, this meta-analysis shows that the IL-1F10.3 and IL-1A+889 polymorphisms are associated with the development of AS in Europeans but not in Asians.

KW - Ankylosing spondylitis

KW - Interleukin-1

KW - Meta-analysis

KW - Polymorphism

UR - http://www.scopus.com/inward/record.url?scp=84863186333&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863186333&partnerID=8YFLogxK

U2 - 10.1016/j.jbspin.2011.06.010

DO - 10.1016/j.jbspin.2011.06.010

M3 - Article

C2 - 21962386

AN - SCOPUS:84863186333

VL - 79

SP - 370

EP - 374

JO - Revue du Rhumatisme (English Edition)

JF - Revue du Rhumatisme (English Edition)

SN - 1169-8446

IS - 4

ER -