The associations of C-reactive protein with serum levels of polyunsaturated fatty acids and trans fatty acids among middle-aged men from three populations

A. El-Saed, K. Masaki, T. Okamura, R. W. Evans, Y. Nakamura, B. J. Willcox, S. Lee, H. Maegawa, T. B. Seto, Jina Choo, A. Fujiyoshi, K. Miura, L. H. Kuller, H. Ueshima, Akira Sekikawa

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: C-reactive protein (CRP) and many fatty acids (FAs) have been linked to cardiovascular disease. Associations of serum CRP with FAs in different populations have not been established. Methods: Participants were 926 men aged 40-49 (2002-2006) from a population-based sample; 310 Whites from Pennsylvania, U.S., 313 Japanese from Shiga, Japan, and 303 Japanese Americans from Hawaii, U.S. Serum CRP (mg/L) was measured using immunosorbent assay while serum FAs (%) were measured using capillary-gasliquid chromatography. Results: Whites had CRP (mg/L) levels higher than Japanese with Japanese Americans in-between (age-adjusted geometric mean “GM” 0.96, 0.38, 0.66, respectively). Whites had also higher levels of total n-6 FAs (%) and trans fatty acids (TFAs) but lower levels of marine-derived n-3 FAs compared to Japanese (41.78 vs. 35.05, 1.04 vs. 0.58, & 3.85 vs. 9.29, respectively). Japanese Americans had FAs levels in-between the other two populations. Whites had significant inverse trends between CRP and tertiles of total n-6 FAs (GM 1.20, 0.91 & 0.80; p=0.002) and marine-derived n-3 FAs (GM 1.22, 1.00 & 0.72; p

Original languageEnglish
Pages (from-to)16-21
Number of pages6
JournalJournal of Nutrition, Health and Aging
Volume20
Issue number1
DOIs
Publication statusPublished - 2016 Jan 1

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Trans Fatty Acids
Unsaturated Fatty Acids
C-Reactive Protein
Fatty Acids
Asian Americans
Serum
Population
Omega-3 Fatty Acids
Blood Proteins
Immunosorbents
Chromatography
Japan
Cardiovascular Diseases

Keywords

  • c-reactive protein
  • caucasian
  • Epidemiology
  • japanese
  • japanese american
  • polyunsaturated fatty acids
  • trans fatty acids

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Geriatrics and Gerontology

Cite this

The associations of C-reactive protein with serum levels of polyunsaturated fatty acids and trans fatty acids among middle-aged men from three populations. / El-Saed, A.; Masaki, K.; Okamura, T.; Evans, R. W.; Nakamura, Y.; Willcox, B. J.; Lee, S.; Maegawa, H.; Seto, T. B.; Choo, Jina; Fujiyoshi, A.; Miura, K.; Kuller, L. H.; Ueshima, H.; Sekikawa, Akira.

In: Journal of Nutrition, Health and Aging, Vol. 20, No. 1, 01.01.2016, p. 16-21.

Research output: Contribution to journalArticle

El-Saed, A, Masaki, K, Okamura, T, Evans, RW, Nakamura, Y, Willcox, BJ, Lee, S, Maegawa, H, Seto, TB, Choo, J, Fujiyoshi, A, Miura, K, Kuller, LH, Ueshima, H & Sekikawa, A 2016, 'The associations of C-reactive protein with serum levels of polyunsaturated fatty acids and trans fatty acids among middle-aged men from three populations', Journal of Nutrition, Health and Aging, vol. 20, no. 1, pp. 16-21. https://doi.org/10.1007/s12603-016-0670-9
El-Saed, A. ; Masaki, K. ; Okamura, T. ; Evans, R. W. ; Nakamura, Y. ; Willcox, B. J. ; Lee, S. ; Maegawa, H. ; Seto, T. B. ; Choo, Jina ; Fujiyoshi, A. ; Miura, K. ; Kuller, L. H. ; Ueshima, H. ; Sekikawa, Akira. / The associations of C-reactive protein with serum levels of polyunsaturated fatty acids and trans fatty acids among middle-aged men from three populations. In: Journal of Nutrition, Health and Aging. 2016 ; Vol. 20, No. 1. pp. 16-21.
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abstract = "Background: C-reactive protein (CRP) and many fatty acids (FAs) have been linked to cardiovascular disease. Associations of serum CRP with FAs in different populations have not been established. Methods: Participants were 926 men aged 40-49 (2002-2006) from a population-based sample; 310 Whites from Pennsylvania, U.S., 313 Japanese from Shiga, Japan, and 303 Japanese Americans from Hawaii, U.S. Serum CRP (mg/L) was measured using immunosorbent assay while serum FAs ({\%}) were measured using capillary-gasliquid chromatography. Results: Whites had CRP (mg/L) levels higher than Japanese with Japanese Americans in-between (age-adjusted geometric mean “GM” 0.96, 0.38, 0.66, respectively). Whites had also higher levels of total n-6 FAs ({\%}) and trans fatty acids (TFAs) but lower levels of marine-derived n-3 FAs compared to Japanese (41.78 vs. 35.05, 1.04 vs. 0.58, & 3.85 vs. 9.29, respectively). Japanese Americans had FAs levels in-between the other two populations. Whites had significant inverse trends between CRP and tertiles of total n-6 FAs (GM 1.20, 0.91 & 0.80; p=0.002) and marine-derived n-3 FAs (GM 1.22, 1.00 & 0.72; p",
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AU - Okamura, T.

AU - Evans, R. W.

AU - Nakamura, Y.

AU - Willcox, B. J.

AU - Lee, S.

AU - Maegawa, H.

AU - Seto, T. B.

AU - Choo, Jina

AU - Fujiyoshi, A.

AU - Miura, K.

AU - Kuller, L. H.

AU - Ueshima, H.

AU - Sekikawa, Akira

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N2 - Background: C-reactive protein (CRP) and many fatty acids (FAs) have been linked to cardiovascular disease. Associations of serum CRP with FAs in different populations have not been established. Methods: Participants were 926 men aged 40-49 (2002-2006) from a population-based sample; 310 Whites from Pennsylvania, U.S., 313 Japanese from Shiga, Japan, and 303 Japanese Americans from Hawaii, U.S. Serum CRP (mg/L) was measured using immunosorbent assay while serum FAs (%) were measured using capillary-gasliquid chromatography. Results: Whites had CRP (mg/L) levels higher than Japanese with Japanese Americans in-between (age-adjusted geometric mean “GM” 0.96, 0.38, 0.66, respectively). Whites had also higher levels of total n-6 FAs (%) and trans fatty acids (TFAs) but lower levels of marine-derived n-3 FAs compared to Japanese (41.78 vs. 35.05, 1.04 vs. 0.58, & 3.85 vs. 9.29, respectively). Japanese Americans had FAs levels in-between the other two populations. Whites had significant inverse trends between CRP and tertiles of total n-6 FAs (GM 1.20, 0.91 & 0.80; p=0.002) and marine-derived n-3 FAs (GM 1.22, 1.00 & 0.72; p

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