The associations of TAC1 gene polymorphisms with major depressive disorder

Eunsoo Won; Kyu Man Han; Aram Kim; Min Soo Lee; Yong Ku Kim; Hun Soo Chang; Byung Joo Ham

doi:10.1007/s13273-019-0016-x

The associations of TAC1 gene polymorphisms with major depressive disorder

Eunsoo Won, Kyu Man Han, Aram Kim, Min Soo Lee, Yong Ku Kim, Hun Soo Chang, Byung Joo Ham

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Backgrounds: Substance P, which is encoded by tachykinin precursor 1 gene (TAC1), has been implicated in the regulation of stress responses and the pathogenesis of major depressive disorder (MDD). Methods: We evaluated the association of 10 SNPs on TAC1 with MDD susceptibility in 111 patients with MDD and 79 control subjects, and with 17-item Hamilton depression rating scale (HAMD17) score in MDD patients. Results: In all subjects, haplotype (ht) 2 homozygous individuals showed higher plasma substance P levels than subjects carrying one or no copy of ht2. The minor allele frequency of rs1397202 was higher in patients with MDD than that in control subjects. Patients homozygous for the minor allele of rs1397202 showed significantly lower HAMD17 scores than patients carrying the common allele. Conclusion: Our results suggest a possible involvement of genetic variants of TAC1 with the plasma level of substance P and symptom severity of MDD.

Original language	English
Pages (from-to)	129-136
Number of pages	8
Journal	Molecular and Cellular Toxicology
Volume	15
Issue number	2
DOIs	https://doi.org/10.1007/s13273-019-0016-x
Publication status	Published - 2019 Apr 1

Keywords

Major depressive disorder
Substance P
Tachykinin precursor 1 gene

ASJC Scopus subject areas

Pathology and Forensic Medicine
Toxicology
Pharmacology, Toxicology and Pharmaceutics(all)
Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s13273-019-0016-x

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title = "The associations of TAC1 gene polymorphisms with major depressive disorder",

abstract = "Backgrounds: Substance P, which is encoded by tachykinin precursor 1 gene (TAC1), has been implicated in the regulation of stress responses and the pathogenesis of major depressive disorder (MDD). Methods: We evaluated the association of 10 SNPs on TAC1 with MDD susceptibility in 111 patients with MDD and 79 control subjects, and with 17-item Hamilton depression rating scale (HAMD17) score in MDD patients. Results: In all subjects, haplotype (ht) 2 homozygous individuals showed higher plasma substance P levels than subjects carrying one or no copy of ht2. The minor allele frequency of rs1397202 was higher in patients with MDD than that in control subjects. Patients homozygous for the minor allele of rs1397202 showed significantly lower HAMD17 scores than patients carrying the common allele. Conclusion: Our results suggest a possible involvement of genetic variants of TAC1 with the plasma level of substance P and symptom severity of MDD.",

keywords = "Major depressive disorder, Substance P, Tachykinin precursor 1 gene",

author = "Eunsoo Won and Han, {Kyu Man} and Aram Kim and Lee, {Min Soo} and Kim, {Yong Ku} and Chang, {Hun Soo} and Ham, {Byung Joo}",

note = "Funding Information: Acknowledgements This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science, ICT & Future Planning (NRF-2016 M3A9A7916996 and NRF-2015R1D1A1A01059914). Publisher Copyright: {\textcopyright} 2019, The Korean Society of Toxicogenomics and Toxicoproteomics and Springer Nature B.V.",

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doi = "10.1007/s13273-019-0016-x",

language = "English",

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T1 - The associations of TAC1 gene polymorphisms with major depressive disorder

AU - Won, Eunsoo

AU - Han, Kyu Man

AU - Kim, Aram

AU - Lee, Min Soo

AU - Kim, Yong Ku

AU - Chang, Hun Soo

AU - Ham, Byung Joo

N1 - Funding Information: Acknowledgements This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science, ICT & Future Planning (NRF-2016 M3A9A7916996 and NRF-2015R1D1A1A01059914). Publisher Copyright: © 2019, The Korean Society of Toxicogenomics and Toxicoproteomics and Springer Nature B.V.

PY - 2019/4/1

Y1 - 2019/4/1

N2 - Backgrounds: Substance P, which is encoded by tachykinin precursor 1 gene (TAC1), has been implicated in the regulation of stress responses and the pathogenesis of major depressive disorder (MDD). Methods: We evaluated the association of 10 SNPs on TAC1 with MDD susceptibility in 111 patients with MDD and 79 control subjects, and with 17-item Hamilton depression rating scale (HAMD17) score in MDD patients. Results: In all subjects, haplotype (ht) 2 homozygous individuals showed higher plasma substance P levels than subjects carrying one or no copy of ht2. The minor allele frequency of rs1397202 was higher in patients with MDD than that in control subjects. Patients homozygous for the minor allele of rs1397202 showed significantly lower HAMD17 scores than patients carrying the common allele. Conclusion: Our results suggest a possible involvement of genetic variants of TAC1 with the plasma level of substance P and symptom severity of MDD.

AB - Backgrounds: Substance P, which is encoded by tachykinin precursor 1 gene (TAC1), has been implicated in the regulation of stress responses and the pathogenesis of major depressive disorder (MDD). Methods: We evaluated the association of 10 SNPs on TAC1 with MDD susceptibility in 111 patients with MDD and 79 control subjects, and with 17-item Hamilton depression rating scale (HAMD17) score in MDD patients. Results: In all subjects, haplotype (ht) 2 homozygous individuals showed higher plasma substance P levels than subjects carrying one or no copy of ht2. The minor allele frequency of rs1397202 was higher in patients with MDD than that in control subjects. Patients homozygous for the minor allele of rs1397202 showed significantly lower HAMD17 scores than patients carrying the common allele. Conclusion: Our results suggest a possible involvement of genetic variants of TAC1 with the plasma level of substance P and symptom severity of MDD.

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The associations of TAC1 gene polymorphisms with major depressive disorder

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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