Abstract
Objectives. This study evaluated the benefits of performing prophylactic central neck dissection (CND) with total thyroidectomy (TT) in management of papillary thyroid carcinoma (PTC) patients who were clinically node-negative at presentation. Methods. A total of 257 patients with stage T1 or T2 PTC and without preoperative evidence of lymph node involvement (N0) were enrolled in this prospective study. The patients were randomly assigned to two groups: (1) a total thyroidectomy (TT) group (n = 104) or (2) a TT plus CND group (n = 153). The two groups were compared for their perioperative data, complication rates, disease recurrence rates, and clinical outcomes. Results. The two groups of patients were similar in age, sex ratio, follow-up duration, and tumor size (P = 0.227, 0.359, 0.214, and 0.878, resp.). The two groups showed similar rates of disease recurrence (3.9% in the TT group versus 3.3% in the TT plus CND group); however, complications occurred more frequently in the TT plus CND group; especially transient hypocalcemia (P = 0.043). Conclusions. Patients treated with TT plus CND had a higher rate of complications with similar recurrence rate. We believe that CND may not be routinely recommended when treating patients with PTC.
| Original language | English |
|---|---|
| Article number | 571480 |
| Journal | International Journal of Endocrinology |
| Volume | 2015 |
| DOIs | |
| Publication status | Published - 2015 |
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ASJC Scopus subject areas
- Endocrine and Autonomic Systems
- Endocrinology
- Endocrinology, Diabetes and Metabolism
Cite this
The Benefits and Risks of Prophylactic Central Neck Dissection for Papillary Thyroid Carcinoma : Prospective Cohort Study. / Lee, Doh Young; Oh, Kyoung Ho; Cho, Jae-Gu; Kwon, Soon Young; Woo, Jeong-Soo; Baek, Seung-Kuk; Jung, Kwang-Yoon.
In: International Journal of Endocrinology, Vol. 2015, 571480, 2015.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The Benefits and Risks of Prophylactic Central Neck Dissection for Papillary Thyroid Carcinoma
T2 - Prospective Cohort Study
AU - Lee, Doh Young
AU - Oh, Kyoung Ho
AU - Cho, Jae-Gu
AU - Kwon, Soon Young
AU - Woo, Jeong-Soo
AU - Baek, Seung-Kuk
AU - Jung, Kwang-Yoon
PY - 2015
Y1 - 2015
N2 - Objectives. This study evaluated the benefits of performing prophylactic central neck dissection (CND) with total thyroidectomy (TT) in management of papillary thyroid carcinoma (PTC) patients who were clinically node-negative at presentation. Methods. A total of 257 patients with stage T1 or T2 PTC and without preoperative evidence of lymph node involvement (N0) were enrolled in this prospective study. The patients were randomly assigned to two groups: (1) a total thyroidectomy (TT) group (n = 104) or (2) a TT plus CND group (n = 153). The two groups were compared for their perioperative data, complication rates, disease recurrence rates, and clinical outcomes. Results. The two groups of patients were similar in age, sex ratio, follow-up duration, and tumor size (P = 0.227, 0.359, 0.214, and 0.878, resp.). The two groups showed similar rates of disease recurrence (3.9% in the TT group versus 3.3% in the TT plus CND group); however, complications occurred more frequently in the TT plus CND group; especially transient hypocalcemia (P = 0.043). Conclusions. Patients treated with TT plus CND had a higher rate of complications with similar recurrence rate. We believe that CND may not be routinely recommended when treating patients with PTC.
AB - Objectives. This study evaluated the benefits of performing prophylactic central neck dissection (CND) with total thyroidectomy (TT) in management of papillary thyroid carcinoma (PTC) patients who were clinically node-negative at presentation. Methods. A total of 257 patients with stage T1 or T2 PTC and without preoperative evidence of lymph node involvement (N0) were enrolled in this prospective study. The patients were randomly assigned to two groups: (1) a total thyroidectomy (TT) group (n = 104) or (2) a TT plus CND group (n = 153). The two groups were compared for their perioperative data, complication rates, disease recurrence rates, and clinical outcomes. Results. The two groups of patients were similar in age, sex ratio, follow-up duration, and tumor size (P = 0.227, 0.359, 0.214, and 0.878, resp.). The two groups showed similar rates of disease recurrence (3.9% in the TT group versus 3.3% in the TT plus CND group); however, complications occurred more frequently in the TT plus CND group; especially transient hypocalcemia (P = 0.043). Conclusions. Patients treated with TT plus CND had a higher rate of complications with similar recurrence rate. We believe that CND may not be routinely recommended when treating patients with PTC.
UR - http://www.scopus.com/inward/record.url?scp=84938117665&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84938117665&partnerID=8YFLogxK
U2 - 10.1155/2015/571480
DO - 10.1155/2015/571480
M3 - Article
AN - SCOPUS:84938117665
VL - 2015
JO - International Journal of Endocrinology
JF - International Journal of Endocrinology
SN - 1687-8337
M1 - 571480
ER -